Immunohistochemical characteristics of bone forming cells in pleomorphic adenoma

Keisuke Nakano, Takehiro Watanabe, Takako Shimizu, Toshiyuki Kawakami

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Histopathological and immunohistochemical examinations were carried out in a case of pleomorphic adenoma with bone formation, occurring in the chin of a 34-year-old Japanese man. Examination results showed the modified neoplastic myoepithelial cells reacted positively to S-100 protein. The S-100-positive modified neoplastic myoepithelial cells were proliferated in the closely related area of the bone tissue. Furthermore, positive reaction was detected in the bone forming cells: osteoblasts and osteocytes. These cells also reacted positively to Runx2 as a marker of bone forming cells. These results suggest that the origin of the bone forming cells in this case of pleomorphic adenoma was modified neoplastic myoepithelial cells.

Original languageEnglish
Pages (from-to)264-266
Number of pages3
JournalInternational journal of medical sciences
Volume4
Issue number5
DOIs
Publication statusPublished - Oct 16 2007
Externally publishedYes

Keywords

  • Bone forming cells
  • Immunohistochemical characteristics
  • Modified myoepithelial cell
  • Pleomorphic adenoma
  • Trans-differentiation

ASJC Scopus subject areas

  • Medicine(all)

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