Abstract
Immunoglobulin (Ig) G4-related disease has been recently described. This disease affects various organs, including lymph nodes. We describe the case of a 52-year-old Japanese man with IgG4-related lymphadenopathy with inflammatory pseudotumor (IPT)-like features. Five years ago, the patient noticed a painless mass in the mandible but did not consult a doctor. Recently, he noted that the mass had increased in size and consulted an oral surgeon in the hospital. Excisional biopsy was performed for diagnosis. Histopathological examination revealed that most of the enlarged lymph node was occupied by the hyalinized tissue. A few residual lymphoid follicles with hyperplastic germinal centers and infiltration of plasma cells and eosinophils were observed. Most of the plasma cells expressed IgG4, and the ratio of IgG4-positive cells to IgG-positive cells was 57.1%. These findings were consistent with IgG4-related lymphadenopathy. In conclusion, pathologists should consider IgG4-related lymphadenopathy when diagnosing a lesion with IPT-like features.
| Original language | English |
|---|---|
| Pages (from-to) | 179-182 |
| Number of pages | 4 |
| Journal | Medical Molecular Morphology |
| Volume | 44 |
| Issue number | 3 |
| DOIs | |
| Publication status | Published - Sep 2011 |
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Keywords
- Histopathology
- IgG4-related disease
- Inflammatory pseudotumor
- Lymph node
- Lymphadenopathy
ASJC Scopus subject areas
- Pathology and Forensic Medicine
- Molecular Biology
Cite this
Immunoglobulin G4-related lymphadenopathy with inflammatory pseudotumor-like features. / Sato, Yasuharu; Kojima, Masaru; Takata, Katsuyoshi; Huang, Xingang; Hayashi, Eiko; Manabe, Akihiro; Miki, Yukari; Yoshino, Tadashi.
In: Medical Molecular Morphology, Vol. 44, No. 3, 09.2011, p. 179-182.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Immunoglobulin G4-related lymphadenopathy with inflammatory pseudotumor-like features
AU - Sato, Yasuharu
AU - Kojima, Masaru
AU - Takata, Katsuyoshi
AU - Huang, Xingang
AU - Hayashi, Eiko
AU - Manabe, Akihiro
AU - Miki, Yukari
AU - Yoshino, Tadashi
PY - 2011/9
Y1 - 2011/9
N2 - Immunoglobulin (Ig) G4-related disease has been recently described. This disease affects various organs, including lymph nodes. We describe the case of a 52-year-old Japanese man with IgG4-related lymphadenopathy with inflammatory pseudotumor (IPT)-like features. Five years ago, the patient noticed a painless mass in the mandible but did not consult a doctor. Recently, he noted that the mass had increased in size and consulted an oral surgeon in the hospital. Excisional biopsy was performed for diagnosis. Histopathological examination revealed that most of the enlarged lymph node was occupied by the hyalinized tissue. A few residual lymphoid follicles with hyperplastic germinal centers and infiltration of plasma cells and eosinophils were observed. Most of the plasma cells expressed IgG4, and the ratio of IgG4-positive cells to IgG-positive cells was 57.1%. These findings were consistent with IgG4-related lymphadenopathy. In conclusion, pathologists should consider IgG4-related lymphadenopathy when diagnosing a lesion with IPT-like features.
AB - Immunoglobulin (Ig) G4-related disease has been recently described. This disease affects various organs, including lymph nodes. We describe the case of a 52-year-old Japanese man with IgG4-related lymphadenopathy with inflammatory pseudotumor (IPT)-like features. Five years ago, the patient noticed a painless mass in the mandible but did not consult a doctor. Recently, he noted that the mass had increased in size and consulted an oral surgeon in the hospital. Excisional biopsy was performed for diagnosis. Histopathological examination revealed that most of the enlarged lymph node was occupied by the hyalinized tissue. A few residual lymphoid follicles with hyperplastic germinal centers and infiltration of plasma cells and eosinophils were observed. Most of the plasma cells expressed IgG4, and the ratio of IgG4-positive cells to IgG-positive cells was 57.1%. These findings were consistent with IgG4-related lymphadenopathy. In conclusion, pathologists should consider IgG4-related lymphadenopathy when diagnosing a lesion with IPT-like features.
KW - Histopathology
KW - IgG4-related disease
KW - Inflammatory pseudotumor
KW - Lymph node
KW - Lymphadenopathy
UR - http://www.scopus.com/inward/record.url?scp=81355135342&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=81355135342&partnerID=8YFLogxK
U2 - 10.1007/s00795-010-0525-0
DO - 10.1007/s00795-010-0525-0
M3 - Article
C2 - 21922391
AN - SCOPUS:81355135342
VL - 44
SP - 179
EP - 182
JO - Medical Electron Microscopy
JF - Medical Electron Microscopy
SN - 0918-4287
IS - 3
ER -