Immunoglobulin G4-related lymphadenopathy with inflammatory pseudotumor-like features

Yasuharu Sato, Masaru Kojima, Katsuyoshi Takata, Xingang Huang, Eiko Hayashi, Akihiro Manabe, Yukari Miki, Tadashi Yoshino

Research output: Contribution to journalArticlepeer-review

13 Citations (Scopus)


Immunoglobulin (Ig) G4-related disease has been recently described. This disease affects various organs, including lymph nodes. We describe the case of a 52-year-old Japanese man with IgG4-related lymphadenopathy with inflammatory pseudotumor (IPT)-like features. Five years ago, the patient noticed a painless mass in the mandible but did not consult a doctor. Recently, he noted that the mass had increased in size and consulted an oral surgeon in the hospital. Excisional biopsy was performed for diagnosis. Histopathological examination revealed that most of the enlarged lymph node was occupied by the hyalinized tissue. A few residual lymphoid follicles with hyperplastic germinal centers and infiltration of plasma cells and eosinophils were observed. Most of the plasma cells expressed IgG4, and the ratio of IgG4-positive cells to IgG-positive cells was 57.1%. These findings were consistent with IgG4-related lymphadenopathy. In conclusion, pathologists should consider IgG4-related lymphadenopathy when diagnosing a lesion with IPT-like features.

Original languageEnglish
Pages (from-to)179-182
Number of pages4
JournalMedical Molecular Morphology
Issue number3
Publication statusPublished - Sept 2011


  • Histopathology
  • IgG4-related disease
  • Inflammatory pseudotumor
  • Lymph node
  • Lymphadenopathy

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Molecular Biology


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