Abstract
Oxidized low-density lipoprotein (oxLDL) promotes atherosclerosis through a complex interaction of inflammatory and immunologic factors that lead to macrophage lipid uptake and foam cell formation. OxLDL interacts with β2-glycoprotein I (β2GPI) forming oxLDL/β2GPI complexes. These complexes may be formed in the arterial intima during atherogenesis and released into the circulation. Autoantibodies against oxLDL/β2GPI complexes have been demonstrated in patients with systemic lupus erythematosus and/or antiphospholipid syndrome, and shown to be significantly associated with arterial thrombosis. The observation that monoclonal autoantibodies against oxLDL/β2GPI complexes significantly increased the oxLDL uptake by macrophages strongly suggests that such IgG autoantibodies are pro-atherogenic. In this article, we review the recent progress in our understanding of LDL oxidation, oxLDL/β2GPI complex formation, and immune regulation of atherogenesis.
Original language | English |
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Pages (from-to) | 12-19 |
Number of pages | 8 |
Journal | Clinical Reviews in Allergy and Immunology |
Volume | 37 |
Issue number | 1 |
DOIs | |
Publication status | Published - 2009 |
Keywords
- Antiphospholipid antibodies
- Atherosclerosis
- Autoimmunity
- Oxidized LDL
- β2GPI
ASJC Scopus subject areas
- Immunology and Allergy