Immune-neuroendocrine interactions during aging: Age-dependent thyrotropin-inhibiting activity of thymosin peptides

Rodolfo G. Goya, Sumio Takahashi, Kathleen L. Quigley, Yolanda E. Sosa, Allan L. Goldstein, Joseph Meites

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

Thymosin fraction 5 (TF-5), a partially purified thymic preparation, has been previously shown to have luteinizing hormone-releasing hormone (LH-RH)-releasing activity in perfused rat hypothalamus as well as in vivo stimulatory effect on the pituitary-adrenal axis in prepubertal monkeys. We report here the effect of TF-5 on the TSH-thyroid axis in young (3 months) and old (25 months) Sprague-Dawley male rats. Conscious free-moving animals carrying an indwelling atrial cannula received a single dose of 5 mg/kg body wt. of either bovine serum albumin (BSA) or TF-5 via the cannula. In the young rats, TF-5 induced a marked reduction of plasma thyrotropin (TSH) which was significantly greater than the normal circadian decline observed in the BSA-treated controls. The old males displayed high basal levels of TSH which showed no circadian rhythmicity, and did not respond to TF-5. Thyroxine (T 4 ), triiodothyronine (T 3 ), corticosterone, and prolactin levels were not affected by TF-5 at the dose levels tested. The old rats had significantly lower basal levels of T 4 , but not T 3 , than their young counterparts. The synthetic peptides thymosin α-1 and serum thymic factor, which are components of TF-5, had no effect on the above hormones when injected in doses up to 5 μg/kg body wt. Acute thymectomy in 3-month-old males induced a significant increase in basal levels of TSH without affecting plasma T 4 or T 3 . These results suggest that the thymus has an inhibitory action on TSH in the rat, which is not mediated by the thyroid gland. Our results also suggest an age-related desensitization of the TSH system to thymic influence in this species.

Original languageEnglish
Pages (from-to)219-227
Number of pages9
JournalMechanisms of Ageing and Development
Volume41
Issue number3
DOIs
Publication statusPublished - Dec 1987
Externally publishedYes

Fingerprint

Thymosin
Thyrotropin
Peptides
Bovine Serum Albumin
Thyroid Gland
Circulating Thymic Factor
Thymectomy
Triiodothyronine
Periodicity
Corticosterone
thymosin fraction 5
Thyroxine
Gonadotropin-Releasing Hormone
Prolactin
Thymus Gland
Hypothalamus
Haplorhini
Sprague Dawley Rats
Hormones

Keywords

  • Age-related response
  • Aging
  • Thymus
  • Thyrotropin
  • TSH inhibition

ASJC Scopus subject areas

  • Ageing
  • Developmental Biology

Cite this

Immune-neuroendocrine interactions during aging : Age-dependent thyrotropin-inhibiting activity of thymosin peptides. / Goya, Rodolfo G.; Takahashi, Sumio; Quigley, Kathleen L.; Sosa, Yolanda E.; Goldstein, Allan L.; Meites, Joseph.

In: Mechanisms of Ageing and Development, Vol. 41, No. 3, 12.1987, p. 219-227.

Research output: Contribution to journalArticle

Goya, Rodolfo G. ; Takahashi, Sumio ; Quigley, Kathleen L. ; Sosa, Yolanda E. ; Goldstein, Allan L. ; Meites, Joseph. / Immune-neuroendocrine interactions during aging : Age-dependent thyrotropin-inhibiting activity of thymosin peptides. In: Mechanisms of Ageing and Development. 1987 ; Vol. 41, No. 3. pp. 219-227.
@article{aeb4d0cc02ac41359747a089dba282c2,
title = "Immune-neuroendocrine interactions during aging: Age-dependent thyrotropin-inhibiting activity of thymosin peptides",
abstract = "Thymosin fraction 5 (TF-5), a partially purified thymic preparation, has been previously shown to have luteinizing hormone-releasing hormone (LH-RH)-releasing activity in perfused rat hypothalamus as well as in vivo stimulatory effect on the pituitary-adrenal axis in prepubertal monkeys. We report here the effect of TF-5 on the TSH-thyroid axis in young (3 months) and old (25 months) Sprague-Dawley male rats. Conscious free-moving animals carrying an indwelling atrial cannula received a single dose of 5 mg/kg body wt. of either bovine serum albumin (BSA) or TF-5 via the cannula. In the young rats, TF-5 induced a marked reduction of plasma thyrotropin (TSH) which was significantly greater than the normal circadian decline observed in the BSA-treated controls. The old males displayed high basal levels of TSH which showed no circadian rhythmicity, and did not respond to TF-5. Thyroxine (T 4 ), triiodothyronine (T 3 ), corticosterone, and prolactin levels were not affected by TF-5 at the dose levels tested. The old rats had significantly lower basal levels of T 4 , but not T 3 , than their young counterparts. The synthetic peptides thymosin α-1 and serum thymic factor, which are components of TF-5, had no effect on the above hormones when injected in doses up to 5 μg/kg body wt. Acute thymectomy in 3-month-old males induced a significant increase in basal levels of TSH without affecting plasma T 4 or T 3 . These results suggest that the thymus has an inhibitory action on TSH in the rat, which is not mediated by the thyroid gland. Our results also suggest an age-related desensitization of the TSH system to thymic influence in this species.",
keywords = "Age-related response, Aging, Thymus, Thyrotropin, TSH inhibition",
author = "Goya, {Rodolfo G.} and Sumio Takahashi and Quigley, {Kathleen L.} and Sosa, {Yolanda E.} and Goldstein, {Allan L.} and Joseph Meites",
year = "1987",
month = "12",
doi = "10.1016/0047-6374(87)90042-X",
language = "English",
volume = "41",
pages = "219--227",
journal = "Mechanisms of Ageing and Development",
issn = "0047-6374",
publisher = "Elsevier Ireland Ltd",
number = "3",

}

TY - JOUR

T1 - Immune-neuroendocrine interactions during aging

T2 - Age-dependent thyrotropin-inhibiting activity of thymosin peptides

AU - Goya, Rodolfo G.

AU - Takahashi, Sumio

AU - Quigley, Kathleen L.

AU - Sosa, Yolanda E.

AU - Goldstein, Allan L.

AU - Meites, Joseph

PY - 1987/12

Y1 - 1987/12

N2 - Thymosin fraction 5 (TF-5), a partially purified thymic preparation, has been previously shown to have luteinizing hormone-releasing hormone (LH-RH)-releasing activity in perfused rat hypothalamus as well as in vivo stimulatory effect on the pituitary-adrenal axis in prepubertal monkeys. We report here the effect of TF-5 on the TSH-thyroid axis in young (3 months) and old (25 months) Sprague-Dawley male rats. Conscious free-moving animals carrying an indwelling atrial cannula received a single dose of 5 mg/kg body wt. of either bovine serum albumin (BSA) or TF-5 via the cannula. In the young rats, TF-5 induced a marked reduction of plasma thyrotropin (TSH) which was significantly greater than the normal circadian decline observed in the BSA-treated controls. The old males displayed high basal levels of TSH which showed no circadian rhythmicity, and did not respond to TF-5. Thyroxine (T 4 ), triiodothyronine (T 3 ), corticosterone, and prolactin levels were not affected by TF-5 at the dose levels tested. The old rats had significantly lower basal levels of T 4 , but not T 3 , than their young counterparts. The synthetic peptides thymosin α-1 and serum thymic factor, which are components of TF-5, had no effect on the above hormones when injected in doses up to 5 μg/kg body wt. Acute thymectomy in 3-month-old males induced a significant increase in basal levels of TSH without affecting plasma T 4 or T 3 . These results suggest that the thymus has an inhibitory action on TSH in the rat, which is not mediated by the thyroid gland. Our results also suggest an age-related desensitization of the TSH system to thymic influence in this species.

AB - Thymosin fraction 5 (TF-5), a partially purified thymic preparation, has been previously shown to have luteinizing hormone-releasing hormone (LH-RH)-releasing activity in perfused rat hypothalamus as well as in vivo stimulatory effect on the pituitary-adrenal axis in prepubertal monkeys. We report here the effect of TF-5 on the TSH-thyroid axis in young (3 months) and old (25 months) Sprague-Dawley male rats. Conscious free-moving animals carrying an indwelling atrial cannula received a single dose of 5 mg/kg body wt. of either bovine serum albumin (BSA) or TF-5 via the cannula. In the young rats, TF-5 induced a marked reduction of plasma thyrotropin (TSH) which was significantly greater than the normal circadian decline observed in the BSA-treated controls. The old males displayed high basal levels of TSH which showed no circadian rhythmicity, and did not respond to TF-5. Thyroxine (T 4 ), triiodothyronine (T 3 ), corticosterone, and prolactin levels were not affected by TF-5 at the dose levels tested. The old rats had significantly lower basal levels of T 4 , but not T 3 , than their young counterparts. The synthetic peptides thymosin α-1 and serum thymic factor, which are components of TF-5, had no effect on the above hormones when injected in doses up to 5 μg/kg body wt. Acute thymectomy in 3-month-old males induced a significant increase in basal levels of TSH without affecting plasma T 4 or T 3 . These results suggest that the thymus has an inhibitory action on TSH in the rat, which is not mediated by the thyroid gland. Our results also suggest an age-related desensitization of the TSH system to thymic influence in this species.

KW - Age-related response

KW - Aging

KW - Thymus

KW - Thyrotropin

KW - TSH inhibition

UR - http://www.scopus.com/inward/record.url?scp=0023605355&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0023605355&partnerID=8YFLogxK

U2 - 10.1016/0047-6374(87)90042-X

DO - 10.1016/0047-6374(87)90042-X

M3 - Article

C2 - 3431174

AN - SCOPUS:0023605355

VL - 41

SP - 219

EP - 227

JO - Mechanisms of Ageing and Development

JF - Mechanisms of Ageing and Development

SN - 0047-6374

IS - 3

ER -