Immune Modulation by Telomerase-Specific Oncolytic Adenovirus Synergistically Enhances Antitumor Efficacy with Anti-PD1 Antibody

Nobuhiko Kanaya, Shinji Kuroda, Yoshihiko Kakiuchi, Kento Kumon, Tomoko Tsumura, Masashi Hashimoto, Toshiaki Morihiro, Tetsushi Kubota, Katsuyuki Aoyama, Satoru Kikuchi, Masahiko Nishizaki, Shunsuke Kagawa, Hiroshi Tazawa, Hiroyuki Mizuguchi, Yasuo Urata, Toshiyoshi Fujiwara

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Kanaya and colleagues show that telomerase-specific oncolytic adenoviruses can facilitate cytotoxic T lymphocytes recruitment into tumor tissues through immunogenic cell death induction, leading to abscopal effects via activation of systemic antitumor immune responses, and combination therapy with anti-PD-1 antibody creates synergistic antitumor effects that even lead to tumor eradication.

Original languageEnglish
Pages (from-to)794-804
Number of pages11
JournalMolecular Therapy
Volume28
Issue number3
DOIs
Publication statusPublished - Mar 4 2020

Keywords

  • CD8
  • abscopal effect
  • combined immunotherapy
  • immune checkpoint
  • immunogenic cell death
  • oncolytic adenovirus
  • programmed death-1
  • tumor infiltrating lymphocytes

ASJC Scopus subject areas

  • Molecular Medicine
  • Molecular Biology
  • Genetics
  • Pharmacology
  • Drug Discovery

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