Immune complex glomerulonephritis in a pregnant woman with congenital C9 deficiency

Kazue Hironaka, Hirofumi Makino, Tetsuki Amano, Zensuke Ota

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

A 27-year-old woman developed proteinuria, hypertension, and peripheral edema during the ninth month of her first pregnancy. The clinical and serological features were compatible with a diagnosis of toxemia of pregnancy, except for the presence of hypocomplementemia. The patient had glomerulonephritis characterized by large electron-dense deposits, predominantly in the mesangium. Immunofluorescence studies revealed striking accumulations of Clq and C3, and the presence of small amounts of IgG and IgM in the mesangium. Serum and plasma levels of complement components were normal, except for the C9 component. Family studies demonstrated that the C9 deficiency was inherited. (Internal Medicine 32: 806–809, 1993).

Original languageEnglish
Pages (from-to)806-809
Number of pages4
JournalInternal Medicine
Volume32
Issue number10
DOIs
Publication statusPublished - Jan 1 1993

Fingerprint

Internal Medicine
Glomerulonephritis
Pre-Eclampsia
Antigen-Antibody Complex
Proteinuria
Fluorescent Antibody Technique
Immunoglobulin M
Pregnant Women
Edema
Immunoglobulin G
Electrons
Hypertension
Pregnancy
Serum
C9 Deficiency

Keywords

  • hereditary C9 deficiency
  • immune complex glomerulonephritis
  • toxemia of pregnancy

ASJC Scopus subject areas

  • Internal Medicine

Cite this

Immune complex glomerulonephritis in a pregnant woman with congenital C9 deficiency. / Hironaka, Kazue; Makino, Hirofumi; Amano, Tetsuki; Ota, Zensuke.

In: Internal Medicine, Vol. 32, No. 10, 01.01.1993, p. 806-809.

Research output: Contribution to journalArticle

Hironaka, Kazue ; Makino, Hirofumi ; Amano, Tetsuki ; Ota, Zensuke. / Immune complex glomerulonephritis in a pregnant woman with congenital C9 deficiency. In: Internal Medicine. 1993 ; Vol. 32, No. 10. pp. 806-809.
@article{b7fa3a2cae734c9dbf8f2fa2303fea0e,
title = "Immune complex glomerulonephritis in a pregnant woman with congenital C9 deficiency",
abstract = "A 27-year-old woman developed proteinuria, hypertension, and peripheral edema during the ninth month of her first pregnancy. The clinical and serological features were compatible with a diagnosis of toxemia of pregnancy, except for the presence of hypocomplementemia. The patient had glomerulonephritis characterized by large electron-dense deposits, predominantly in the mesangium. Immunofluorescence studies revealed striking accumulations of Clq and C3, and the presence of small amounts of IgG and IgM in the mesangium. Serum and plasma levels of complement components were normal, except for the C9 component. Family studies demonstrated that the C9 deficiency was inherited. (Internal Medicine 32: 806–809, 1993).",
keywords = "hereditary C9 deficiency, immune complex glomerulonephritis, toxemia of pregnancy",
author = "Kazue Hironaka and Hirofumi Makino and Tetsuki Amano and Zensuke Ota",
year = "1993",
month = "1",
day = "1",
doi = "10.2169/internalmedicine.32.806",
language = "English",
volume = "32",
pages = "806--809",
journal = "Internal Medicine",
issn = "0918-2918",
publisher = "Japanese Society of Internal Medicine",
number = "10",

}

TY - JOUR

T1 - Immune complex glomerulonephritis in a pregnant woman with congenital C9 deficiency

AU - Hironaka, Kazue

AU - Makino, Hirofumi

AU - Amano, Tetsuki

AU - Ota, Zensuke

PY - 1993/1/1

Y1 - 1993/1/1

N2 - A 27-year-old woman developed proteinuria, hypertension, and peripheral edema during the ninth month of her first pregnancy. The clinical and serological features were compatible with a diagnosis of toxemia of pregnancy, except for the presence of hypocomplementemia. The patient had glomerulonephritis characterized by large electron-dense deposits, predominantly in the mesangium. Immunofluorescence studies revealed striking accumulations of Clq and C3, and the presence of small amounts of IgG and IgM in the mesangium. Serum and plasma levels of complement components were normal, except for the C9 component. Family studies demonstrated that the C9 deficiency was inherited. (Internal Medicine 32: 806–809, 1993).

AB - A 27-year-old woman developed proteinuria, hypertension, and peripheral edema during the ninth month of her first pregnancy. The clinical and serological features were compatible with a diagnosis of toxemia of pregnancy, except for the presence of hypocomplementemia. The patient had glomerulonephritis characterized by large electron-dense deposits, predominantly in the mesangium. Immunofluorescence studies revealed striking accumulations of Clq and C3, and the presence of small amounts of IgG and IgM in the mesangium. Serum and plasma levels of complement components were normal, except for the C9 component. Family studies demonstrated that the C9 deficiency was inherited. (Internal Medicine 32: 806–809, 1993).

KW - hereditary C9 deficiency

KW - immune complex glomerulonephritis

KW - toxemia of pregnancy

UR - http://www.scopus.com/inward/record.url?scp=0027684327&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0027684327&partnerID=8YFLogxK

U2 - 10.2169/internalmedicine.32.806

DO - 10.2169/internalmedicine.32.806

M3 - Article

VL - 32

SP - 806

EP - 809

JO - Internal Medicine

JF - Internal Medicine

SN - 0918-2918

IS - 10

ER -