Abstract
Human adult peripheral blood lymphocytes were successfully immortalized by co-cultivation with irradiated autologous and homologous T-cell lines harbouring human T-cell leukaemia virus-I (HTLV-I). The efficiency of transformation was the same in both cases. The participation of alloantigen stimulation in co-cultivation procedures is discussed, and it is stressed that factors other than alloantigen stimulation might be required for the efficient immortalization of human T-lymphocytes in vitro by HTLV.
| Original language | English |
|---|---|
| Pages (from-to) | 82-84 |
| Number of pages | 3 |
| Journal | Journal of cancer research and clinical oncology |
| Volume | 110 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - Jul 1 1985 |
| Externally published | Yes |
Keywords
- Human T-cell leukaemia virus
- Lymphocyte
- Transformation
ASJC Scopus subject areas
- Oncology
- Cancer Research
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Cite this
Akagi, T., Ohtsuki, Y., Takahashi, K., Takeda, I., Oka, T., & Miyoshi, I. (1985). Immortalization of human lymphocytes by co-cultivation with lethally irradiated autologous T-cell lines harbouring human T-cell leukaemia virus-I. Journal of cancer research and clinical oncology, 110(1), 82-84. https://doi.org/10.1007/BF00402508