Immortalization of human lymphocytes by co-cultivation with lethally irradiated autologous T-cell lines harbouring human T-cell leukaemia virus-I

T. Akagi, Y. Ohtsuki, K. Takahashi, I. Takeda, T. Oka, I. Miyoshi

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Human adult peripheral blood lymphocytes were successfully immortalized by co-cultivation with irradiated autologous and homologous T-cell lines harbouring human T-cell leukaemia virus-I (HTLV-I). The efficiency of transformation was the same in both cases. The participation of alloantigen stimulation in co-cultivation procedures is discussed, and it is stressed that factors other than alloantigen stimulation might be required for the efficient immortalization of human T-lymphocytes in vitro by HTLV.

Original languageEnglish
Pages (from-to)82-84
Number of pages3
JournalJournal of cancer research and clinical oncology
Issue number1
Publication statusPublished - Jul 1 1985



  • Human T-cell leukaemia virus
  • Lymphocyte
  • Transformation

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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