Immimohistochemically-determined changes in the distribution of insulin-like growth factor-I (IGF-I) and epidermal growth factor (EGF) in the bovine endometrium during the estrous cycle

Shintaro Ohtani, Kiyoshi Okuda, Masayuki Ohtani, Junzo Yamada

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

The aims of this study were to investigate whether there are cell-specific distributions of insulin-like growth factor I (IGF-I) and epidermal growth factor (EGF) in the endometrium, and to determine whether or not the expression of these factors varies with the stage of the estrous cycle. Fifty-four endometrial biopsy specimens were collected from normal cycle Holstein-Friesian heifers. The endometrial specimens were divided into nine groups (at least five different animals per group) corresponding to the following days of the cycle: days 20-0, 1-3, 4-5, 6-7, 8-10, 11-13, 14-15, 16-17 and 18-19 (day 0=estrus). IGF-I and EGF were localized by immunohistochemistry in the intact heifer endometrium throughout the estrous cycle. Throughout the estrous cycle, IGF-I was localized in the luminal epithelium and stroma with a little staining in the glandular epithelium (P

Original languageEnglish
Pages (from-to)1211-1217
Number of pages7
JournalJournal of Veterinary Medical Science
Volume58
Issue number12
Publication statusPublished - Dec 1996

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Estrous Cycle
endometrium
epidermal growth factor
insulin-like growth factor I
Endometrium
Insulin-Like Growth Factor I
Epidermal Growth Factor
estrous cycle
heifers
cattle
epithelium
Epithelium
Estrus
immunohistochemistry
estrus
biopsy
Holstein
Immunohistochemistry
Staining and Labeling
Biopsy

Keywords

  • Bovine endometrium
  • Epidermal growth factor
  • Immunohistochemistry
  • Insulin-like growth factor I

ASJC Scopus subject areas

  • Marketing
  • veterinary(all)

Cite this

Immimohistochemically-determined changes in the distribution of insulin-like growth factor-I (IGF-I) and epidermal growth factor (EGF) in the bovine endometrium during the estrous cycle. / Ohtani, Shintaro; Okuda, Kiyoshi; Ohtani, Masayuki; Yamada, Junzo.

In: Journal of Veterinary Medical Science, Vol. 58, No. 12, 12.1996, p. 1211-1217.

Research output: Contribution to journalArticle

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