Immaturity of lymphocytes in the metastatic lesions of thymoma

Masayoshi Inoue, Meinoshin Okumura, Yoshitaka Fujii, Shinichiro Miyoshi, Hiroyuki Shiono, Kenjiro Fukuhara, Yoshihisa Kadota, Hikaru Matsuda

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Thymoma is a thymic epithelial tumor which often contains a large number of immature T cells. Although the metastatic lesions are also associated with abundant lymphocytes, their characteristics have not been assessed in detail. In this study, the phenotype was analyzed and compared with those in their primary lesions. Nine metastatic thymomas were obtained from seven patients. In the metastatic lesions, CD1a+ cells and CD4+CD8+ cells accounted for 77.7 ± 10.6 and 52.3 ± 15.8% of all the lymphocytes, respectively. In five primary lesions and their metastatic lesions, CD3-CD4+CD8- cells accounted for 23.9 ± 16.9 and 45.2 ± 15.5% of the CD4+CD8- cells, respectively. CD69 was expressed on 70.9 ± 9.5 and 53.1 ± 11.8% of the CD4+CD8- cells, respectively. These results indicate that the metastatic lesions of thymoma are associated with abundant immature T cells which are phenotypically less mature than those in their primary lesions.

Original languageEnglish
Pages (from-to)249-255
Number of pages7
JournalClinical Immunology and Immunopathology
Volume88
Issue number3
DOIs
Publication statusPublished - Sep 1998
Externally publishedYes

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Thymoma
Lymphocytes
T-Lymphocytes
Phenotype

Keywords

  • CD69
  • Dissemination
  • Metastasis
  • Thymoma

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Pathology and Forensic Medicine

Cite this

Inoue, M., Okumura, M., Fujii, Y., Miyoshi, S., Shiono, H., Fukuhara, K., ... Matsuda, H. (1998). Immaturity of lymphocytes in the metastatic lesions of thymoma. Clinical Immunology and Immunopathology, 88(3), 249-255. https://doi.org/10.1006/clin.1998.4584

Immaturity of lymphocytes in the metastatic lesions of thymoma. / Inoue, Masayoshi; Okumura, Meinoshin; Fujii, Yoshitaka; Miyoshi, Shinichiro; Shiono, Hiroyuki; Fukuhara, Kenjiro; Kadota, Yoshihisa; Matsuda, Hikaru.

In: Clinical Immunology and Immunopathology, Vol. 88, No. 3, 09.1998, p. 249-255.

Research output: Contribution to journalArticle

Inoue, M, Okumura, M, Fujii, Y, Miyoshi, S, Shiono, H, Fukuhara, K, Kadota, Y & Matsuda, H 1998, 'Immaturity of lymphocytes in the metastatic lesions of thymoma', Clinical Immunology and Immunopathology, vol. 88, no. 3, pp. 249-255. https://doi.org/10.1006/clin.1998.4584
Inoue M, Okumura M, Fujii Y, Miyoshi S, Shiono H, Fukuhara K et al. Immaturity of lymphocytes in the metastatic lesions of thymoma. Clinical Immunology and Immunopathology. 1998 Sep;88(3):249-255. https://doi.org/10.1006/clin.1998.4584
Inoue, Masayoshi ; Okumura, Meinoshin ; Fujii, Yoshitaka ; Miyoshi, Shinichiro ; Shiono, Hiroyuki ; Fukuhara, Kenjiro ; Kadota, Yoshihisa ; Matsuda, Hikaru. / Immaturity of lymphocytes in the metastatic lesions of thymoma. In: Clinical Immunology and Immunopathology. 1998 ; Vol. 88, No. 3. pp. 249-255.
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