Abstract
Background: Single nucleotide polymorphisms in the promoter of interleukin (IL)-18 (-607C/A and -137G/C) may affect the clinical course of inflammatory diseases. This study examined the relationship between the plasma IL18 levels, IL18 promoter polymorphism, and outcomes in the intensive care unit (ICU) setting. Patients and Methods: Plasma IL18 levels, IL18 promoter genotype, clinical variables, including APACHE II score, and mortality were examined in 70 ICU patients. Results: Plasma IL18 levels were significantly higher in patients who did not survive the ICU stay than in patients who survived, and were correlated with APACHE II score. When examined by IL18 promoter genotype, only patients with the -607CA genotype exhibited differences in IL18 expression between survivors and nonsurvivors. Conclusion: Plasma IL18 levels may predict outcome in patients with sepsis. IL18 promoter polymorphism, especially at -607, may increase IL18 production in some patients and might be useful in predicting the outcome of patients with sepsis in the ICU.
| Original language | English |
|---|---|
| Pages (from-to) | 391-396 |
| Number of pages | 6 |
| Journal | In Vivo |
| Volume | 28 |
| Issue number | 3 |
| Publication status | Published - 2014 |
| Externally published | Yes |
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Keywords
- Interleukin-18
- Promoter regions
- Sepsis
- Single nucleotide polymorphism
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)
- Pharmacology
- Medicine(all)
Cite this
IL18 production and IL18 promoter polymorphisms correlate with mortality in ICU patients. / Yamada, Taihei; Aoyama-Ishikawa, Michiko; Yamashita, Hayato; Fujiwara, Mayu; Usami, Makoto; Ueda, Takahiro; Terashima, Mariko; Kohama, Keisuke; Nakao, Atsunori; Kotani, Joji.
In: In Vivo, Vol. 28, No. 3, 2014, p. 391-396.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - IL18 production and IL18 promoter polymorphisms correlate with mortality in ICU patients
AU - Yamada, Taihei
AU - Aoyama-Ishikawa, Michiko
AU - Yamashita, Hayato
AU - Fujiwara, Mayu
AU - Usami, Makoto
AU - Ueda, Takahiro
AU - Terashima, Mariko
AU - Kohama, Keisuke
AU - Nakao, Atsunori
AU - Kotani, Joji
PY - 2014
Y1 - 2014
N2 - Background: Single nucleotide polymorphisms in the promoter of interleukin (IL)-18 (-607C/A and -137G/C) may affect the clinical course of inflammatory diseases. This study examined the relationship between the plasma IL18 levels, IL18 promoter polymorphism, and outcomes in the intensive care unit (ICU) setting. Patients and Methods: Plasma IL18 levels, IL18 promoter genotype, clinical variables, including APACHE II score, and mortality were examined in 70 ICU patients. Results: Plasma IL18 levels were significantly higher in patients who did not survive the ICU stay than in patients who survived, and were correlated with APACHE II score. When examined by IL18 promoter genotype, only patients with the -607CA genotype exhibited differences in IL18 expression between survivors and nonsurvivors. Conclusion: Plasma IL18 levels may predict outcome in patients with sepsis. IL18 promoter polymorphism, especially at -607, may increase IL18 production in some patients and might be useful in predicting the outcome of patients with sepsis in the ICU.
AB - Background: Single nucleotide polymorphisms in the promoter of interleukin (IL)-18 (-607C/A and -137G/C) may affect the clinical course of inflammatory diseases. This study examined the relationship between the plasma IL18 levels, IL18 promoter polymorphism, and outcomes in the intensive care unit (ICU) setting. Patients and Methods: Plasma IL18 levels, IL18 promoter genotype, clinical variables, including APACHE II score, and mortality were examined in 70 ICU patients. Results: Plasma IL18 levels were significantly higher in patients who did not survive the ICU stay than in patients who survived, and were correlated with APACHE II score. When examined by IL18 promoter genotype, only patients with the -607CA genotype exhibited differences in IL18 expression between survivors and nonsurvivors. Conclusion: Plasma IL18 levels may predict outcome in patients with sepsis. IL18 promoter polymorphism, especially at -607, may increase IL18 production in some patients and might be useful in predicting the outcome of patients with sepsis in the ICU.
KW - Interleukin-18
KW - Promoter regions
KW - Sepsis
KW - Single nucleotide polymorphism
UR - http://www.scopus.com/inward/record.url?scp=84918576131&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84918576131&partnerID=8YFLogxK
M3 - Article
C2 - 24815843
AN - SCOPUS:84918576131
VL - 28
SP - 391
EP - 396
JO - In Vivo
JF - In Vivo
SN - 0258-851X
IS - 3
ER -