IL18 production and IL18 promoter polymorphisms correlate with mortality in ICU patients

Taihei Yamada; Michiko Aoyama-Ishikawa; Hayato Yamashita; Mayu Fujiwara; Makoto Usami; Takahiro Ueda; Mariko Terashima; Keisuke Kohama; Atsunori Nakao; Joji Kotani

IL18 production and IL18 promoter polymorphisms correlate with mortality in ICU patients

Taihei Yamada, Michiko Aoyama-Ishikawa, Hayato Yamashita, Mayu Fujiwara, Makoto Usami, Takahiro Ueda, Mariko Terashima, Keisuke Kohama, Atsunori Nakao, Joji Kotani

Research output: Contribution to journal › Article

1 Citation (Scopus)

Abstract

Background: Single nucleotide polymorphisms in the promoter of interleukin (IL)-18 (-607C/A and -137G/C) may affect the clinical course of inflammatory diseases. This study examined the relationship between the plasma IL18 levels, IL18 promoter polymorphism, and outcomes in the intensive care unit (ICU) setting. Patients and Methods: Plasma IL18 levels, IL18 promoter genotype, clinical variables, including APACHE II score, and mortality were examined in 70 ICU patients. Results: Plasma IL18 levels were significantly higher in patients who did not survive the ICU stay than in patients who survived, and were correlated with APACHE II score. When examined by IL18 promoter genotype, only patients with the -607CA genotype exhibited differences in IL18 expression between survivors and nonsurvivors. Conclusion: Plasma IL18 levels may predict outcome in patients with sepsis. IL18 promoter polymorphism, especially at -607, may increase IL18 production in some patients and might be useful in predicting the outcome of patients with sepsis in the ICU.

Original language	English
Pages (from-to)	391-396
Number of pages	6
Journal	In Vivo
Volume	28
Issue number	3
Publication status	Published - Jan 1 2014
Externally published	Yes

Keywords

Interleukin-18
Promoter regions
Sepsis
Single nucleotide polymorphism

ASJC Scopus subject areas

Biochemistry, Genetics and Molecular Biology(all)
Pharmacology

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Yamada, T., Aoyama-Ishikawa, M., Yamashita, H., Fujiwara, M., Usami, M., Ueda, T., Terashima, M., Kohama, K., Nakao, A., & Kotani, J. (2014). IL18 production and IL18 promoter polymorphisms correlate with mortality in ICU patients. In Vivo, 28(3), 391-396.

IL18 production and IL18 promoter polymorphisms correlate with mortality in ICU patients. / Yamada, Taihei; Aoyama-Ishikawa, Michiko; Yamashita, Hayato; Fujiwara, Mayu; Usami, Makoto; Ueda, Takahiro; Terashima, Mariko; Kohama, Keisuke; Nakao, Atsunori; Kotani, Joji.

In: In Vivo, Vol. 28, No. 3, 01.01.2014, p. 391-396.

Research output: Contribution to journal › Article

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abstract = "Background: Single nucleotide polymorphisms in the promoter of interleukin (IL)-18 (-607C/A and -137G/C) may affect the clinical course of inflammatory diseases. This study examined the relationship between the plasma IL18 levels, IL18 promoter polymorphism, and outcomes in the intensive care unit (ICU) setting. Patients and Methods: Plasma IL18 levels, IL18 promoter genotype, clinical variables, including APACHE II score, and mortality were examined in 70 ICU patients. Results: Plasma IL18 levels were significantly higher in patients who did not survive the ICU stay than in patients who survived, and were correlated with APACHE II score. When examined by IL18 promoter genotype, only patients with the -607CA genotype exhibited differences in IL18 expression between survivors and nonsurvivors. Conclusion: Plasma IL18 levels may predict outcome in patients with sepsis. IL18 promoter polymorphism, especially at -607, may increase IL18 production in some patients and might be useful in predicting the outcome of patients with sepsis in the ICU.",

keywords = "Interleukin-18, Promoter regions, Sepsis, Single nucleotide polymorphism",

author = "Taihei Yamada and Michiko Aoyama-Ishikawa and Hayato Yamashita and Mayu Fujiwara and Makoto Usami and Takahiro Ueda and Mariko Terashima and Keisuke Kohama and Atsunori Nakao and Joji Kotani",

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T1 - IL18 production and IL18 promoter polymorphisms correlate with mortality in ICU patients

AU - Yamada, Taihei

AU - Aoyama-Ishikawa, Michiko

AU - Yamashita, Hayato

AU - Fujiwara, Mayu

AU - Usami, Makoto

AU - Ueda, Takahiro

AU - Terashima, Mariko

AU - Kohama, Keisuke

AU - Nakao, Atsunori

AU - Kotani, Joji

PY - 2014/1/1

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N2 - Background: Single nucleotide polymorphisms in the promoter of interleukin (IL)-18 (-607C/A and -137G/C) may affect the clinical course of inflammatory diseases. This study examined the relationship between the plasma IL18 levels, IL18 promoter polymorphism, and outcomes in the intensive care unit (ICU) setting. Patients and Methods: Plasma IL18 levels, IL18 promoter genotype, clinical variables, including APACHE II score, and mortality were examined in 70 ICU patients. Results: Plasma IL18 levels were significantly higher in patients who did not survive the ICU stay than in patients who survived, and were correlated with APACHE II score. When examined by IL18 promoter genotype, only patients with the -607CA genotype exhibited differences in IL18 expression between survivors and nonsurvivors. Conclusion: Plasma IL18 levels may predict outcome in patients with sepsis. IL18 promoter polymorphism, especially at -607, may increase IL18 production in some patients and might be useful in predicting the outcome of patients with sepsis in the ICU.

AB - Background: Single nucleotide polymorphisms in the promoter of interleukin (IL)-18 (-607C/A and -137G/C) may affect the clinical course of inflammatory diseases. This study examined the relationship between the plasma IL18 levels, IL18 promoter polymorphism, and outcomes in the intensive care unit (ICU) setting. Patients and Methods: Plasma IL18 levels, IL18 promoter genotype, clinical variables, including APACHE II score, and mortality were examined in 70 ICU patients. Results: Plasma IL18 levels were significantly higher in patients who did not survive the ICU stay than in patients who survived, and were correlated with APACHE II score. When examined by IL18 promoter genotype, only patients with the -607CA genotype exhibited differences in IL18 expression between survivors and nonsurvivors. Conclusion: Plasma IL18 levels may predict outcome in patients with sepsis. IL18 promoter polymorphism, especially at -607, may increase IL18 production in some patients and might be useful in predicting the outcome of patients with sepsis in the ICU.

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