IL-17A is essential to the development of elastase-induced pulmonary inflammation and emphysema in mice

Etsuko Kurimoto, Nobuaki Miyahara, Arihiko Kanehiro, Koichi Waseda, Akihiko Taniguchi, Genyo Ikeda, Hikari Koga, Hisakazu Nishimori, Yasushi Tanimoto, Mikio Kataoka, Yoichiro Iwakura, Erwin W. Gelfand, Mitsune Tanimoto

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Abstract

Background: Pulmonary emphysema is characterized by alveolar destruction and persistent inflammation of the airways. Although IL-17A contributes to many chronic inflammatory diseases, it's role in the inflammatory response of elastase-induced emphysema remains unclear.Methods: In a model of elastase-induced pulmonary emphysema we examined the response of IL-17A-deficient mice, monitoring airway inflammation, static compliance, lung histology and levels of neutrophil-related chemokine and pro-inflammatory cytokines in bronchoalveolar lavage (BAL) fluid.Results: Wild-type mice developed emphysematous changes in the lung tissue on day 21 after elastase treatment, whereas emphysematous changes were decreased in IL-17A-deficient mice compared to wild-type mice. Neutrophilia in BAL fluid, seen in elastase-treated wild-type mice, was reduced in elastase-treated IL-17A-deficient mice on day 4, associated with decreased levels of KC, MIP-2 and IL-1 beta. Elastase-treated wild-type mice showed increased IL-17A levels as well as increased numbers of IL-17A+ CD4 T cells in the lung in the initial period following elastase treatment.Conclusions: These data identify the important contribution of IL-17A in the development of elastase-induced pulmonary inflammation and emphysema. Targeting IL-17A in emphysema may be a potential therapeutic strategy for delaying disease progression.

Original languageEnglish
Article number5
JournalRespiratory Research
Volume14
Issue number1
DOIs
Publication statusPublished - Jan 20 2013

Keywords

  • Chronic obstructive pulmonary disease
  • Elastase
  • Emphysema
  • IL-17

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

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    Kurimoto, E., Miyahara, N., Kanehiro, A., Waseda, K., Taniguchi, A., Ikeda, G., Koga, H., Nishimori, H., Tanimoto, Y., Kataoka, M., Iwakura, Y., Gelfand, E. W., & Tanimoto, M. (2013). IL-17A is essential to the development of elastase-induced pulmonary inflammation and emphysema in mice. Respiratory Research, 14(1), [5]. https://doi.org/10.1186/1465-9921-14-5