IL-10 is necessary for the expression of airway hyperresponsiveness but not pulmonary inflammation after allergic sensitization

M. J. Mäkelä, A. Kanehiro, L. Borish, A. Dakhama, J. Loader, A. Joetham, Z. Xing, M. Jordana, G. L. Larsen, E. W. Gelfand

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Abstract

Cytokines play an important role in modulating inflammatory responses and, as a result, airway tone. IL-10 is a regulatory cytokine that has been suggested for treatment of asthma because of its immunosuppressive and anti- inflammatory properties. In contrast to these suggestions, we demonstrate in a model of allergic sensitization that mice deficient in IL-10 (IL-10-/-) develop a pulmonary inflammatory response but fail to exhibit airway hyperresponsiveness in both in vitro and in vivo assessments of lung function. Reconstitution of these deficient mice with the IL-10 gene fully restores development of airway hyperresponsiveness comparable to control mice. These results identify an important role of IL-10, downstream of the inflammatory cascade, in regulating the tone of the airways after allergic sensitization and challenge.

Original languageEnglish
Pages (from-to)6007-6012
Number of pages6
JournalProceedings of the National Academy of Sciences of the United States of America
Volume97
Issue number11
DOIs
Publication statusPublished - May 23 2000

ASJC Scopus subject areas

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    Mäkelä, M. J., Kanehiro, A., Borish, L., Dakhama, A., Loader, J., Joetham, A., Xing, Z., Jordana, M., Larsen, G. L., & Gelfand, E. W. (2000). IL-10 is necessary for the expression of airway hyperresponsiveness but not pulmonary inflammation after allergic sensitization. Proceedings of the National Academy of Sciences of the United States of America, 97(11), 6007-6012. https://doi.org/10.1073/pnas.100118997