III. Chemokines and other mediators, 8. Chemokines and their receptors in cell-mediated immune responses in the lung

Akihiro Matsukawa, Nicholas W. Lukacs, Cory M. Hogaboam, Stephen W. Chensue, Steven L. Kunkel

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

Chemokines constitute a large family of chemotactic cytokines that belong to a super-gene family of 8-10 kDa proteins. The chemokines are considered to be primarily beneficial in host defense against invading pathogens. However, the reactions induced by chemokines can be occasionally excessive, resulting in a harmful response to the host. Recent studies in chemokine biology have elucidated that chemokines are involved in the initiation, development, and maintenance of numbers of diseases including lung diseases. In addition to its chemotactic activity, evidence suggests that chemokines can modify the outcome of the cell-mediated immune responses by altering the Th1/Th2 cytokine profile. Chemokines are also capable of dictating the direction of specific immune responses. Chemokine action is mediated by a large super-family of G-protein coupled receptors, and the receptors are preferentially expressed on Th1/Th2 cells. Certain chemokine receptors are constitutively expressed in immune surveying cells such as dendritic cells and naive T cells. The corresponding chemokines are present in normal lymphoid tissues, suggesting a role of chemokines/receptors in cell homing and cell-cell communication in lymphoid tissue that can be an initial step for immune recognition. Thus, comprehension of the chemokine biology in immune responses appears to be fundamental for understanding the pathogenesis of T cell-mediated immune responses. The following review will highlight the current insight into the role of chemokines and their receptors in the cell-mediated immune response, with a special focus on lung diseases.

Original languageEnglish
Pages (from-to)298-306
Number of pages9
JournalMicroscopy Research and Technique
Volume53
Issue number4
DOIs
Publication statusPublished - May 15 2001
Externally publishedYes

Fingerprint

Pulmonary diseases
T-cells
Chemokine Receptors
chemokines
Chemokines
cell-mediated immunity
lungs
Tissue
Proteins
Lung
receptors
Surveying
Pathogens
cells
Genes
Communication
biology
Lymphoid Tissue
homing
proteins

Keywords

  • Cell-cell communication
  • Chemotactic cytokines
  • Delayed hypersensitivity
  • Th1/Th2

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Anatomy
  • Instrumentation

Cite this

III. Chemokines and other mediators, 8. Chemokines and their receptors in cell-mediated immune responses in the lung. / Matsukawa, Akihiro; Lukacs, Nicholas W.; Hogaboam, Cory M.; Chensue, Stephen W.; Kunkel, Steven L.

In: Microscopy Research and Technique, Vol. 53, No. 4, 15.05.2001, p. 298-306.

Research output: Contribution to journalArticle

Matsukawa, Akihiro ; Lukacs, Nicholas W. ; Hogaboam, Cory M. ; Chensue, Stephen W. ; Kunkel, Steven L. / III. Chemokines and other mediators, 8. Chemokines and their receptors in cell-mediated immune responses in the lung. In: Microscopy Research and Technique. 2001 ; Vol. 53, No. 4. pp. 298-306.
@article{72f74591298a4dd3b5d63ecee9b71321,
title = "III. Chemokines and other mediators, 8. Chemokines and their receptors in cell-mediated immune responses in the lung",
abstract = "Chemokines constitute a large family of chemotactic cytokines that belong to a super-gene family of 8-10 kDa proteins. The chemokines are considered to be primarily beneficial in host defense against invading pathogens. However, the reactions induced by chemokines can be occasionally excessive, resulting in a harmful response to the host. Recent studies in chemokine biology have elucidated that chemokines are involved in the initiation, development, and maintenance of numbers of diseases including lung diseases. In addition to its chemotactic activity, evidence suggests that chemokines can modify the outcome of the cell-mediated immune responses by altering the Th1/Th2 cytokine profile. Chemokines are also capable of dictating the direction of specific immune responses. Chemokine action is mediated by a large super-family of G-protein coupled receptors, and the receptors are preferentially expressed on Th1/Th2 cells. Certain chemokine receptors are constitutively expressed in immune surveying cells such as dendritic cells and naive T cells. The corresponding chemokines are present in normal lymphoid tissues, suggesting a role of chemokines/receptors in cell homing and cell-cell communication in lymphoid tissue that can be an initial step for immune recognition. Thus, comprehension of the chemokine biology in immune responses appears to be fundamental for understanding the pathogenesis of T cell-mediated immune responses. The following review will highlight the current insight into the role of chemokines and their receptors in the cell-mediated immune response, with a special focus on lung diseases.",
keywords = "Cell-cell communication, Chemotactic cytokines, Delayed hypersensitivity, Th1/Th2",
author = "Akihiro Matsukawa and Lukacs, {Nicholas W.} and Hogaboam, {Cory M.} and Chensue, {Stephen W.} and Kunkel, {Steven L.}",
year = "2001",
month = "5",
day = "15",
doi = "10.1002/jemt.1096",
language = "English",
volume = "53",
pages = "298--306",
journal = "Microscopy Research and Technique",
issn = "1059-910X",
publisher = "Wiley-Liss Inc.",
number = "4",

}

TY - JOUR

T1 - III. Chemokines and other mediators, 8. Chemokines and their receptors in cell-mediated immune responses in the lung

AU - Matsukawa, Akihiro

AU - Lukacs, Nicholas W.

AU - Hogaboam, Cory M.

AU - Chensue, Stephen W.

AU - Kunkel, Steven L.

PY - 2001/5/15

Y1 - 2001/5/15

N2 - Chemokines constitute a large family of chemotactic cytokines that belong to a super-gene family of 8-10 kDa proteins. The chemokines are considered to be primarily beneficial in host defense against invading pathogens. However, the reactions induced by chemokines can be occasionally excessive, resulting in a harmful response to the host. Recent studies in chemokine biology have elucidated that chemokines are involved in the initiation, development, and maintenance of numbers of diseases including lung diseases. In addition to its chemotactic activity, evidence suggests that chemokines can modify the outcome of the cell-mediated immune responses by altering the Th1/Th2 cytokine profile. Chemokines are also capable of dictating the direction of specific immune responses. Chemokine action is mediated by a large super-family of G-protein coupled receptors, and the receptors are preferentially expressed on Th1/Th2 cells. Certain chemokine receptors are constitutively expressed in immune surveying cells such as dendritic cells and naive T cells. The corresponding chemokines are present in normal lymphoid tissues, suggesting a role of chemokines/receptors in cell homing and cell-cell communication in lymphoid tissue that can be an initial step for immune recognition. Thus, comprehension of the chemokine biology in immune responses appears to be fundamental for understanding the pathogenesis of T cell-mediated immune responses. The following review will highlight the current insight into the role of chemokines and their receptors in the cell-mediated immune response, with a special focus on lung diseases.

AB - Chemokines constitute a large family of chemotactic cytokines that belong to a super-gene family of 8-10 kDa proteins. The chemokines are considered to be primarily beneficial in host defense against invading pathogens. However, the reactions induced by chemokines can be occasionally excessive, resulting in a harmful response to the host. Recent studies in chemokine biology have elucidated that chemokines are involved in the initiation, development, and maintenance of numbers of diseases including lung diseases. In addition to its chemotactic activity, evidence suggests that chemokines can modify the outcome of the cell-mediated immune responses by altering the Th1/Th2 cytokine profile. Chemokines are also capable of dictating the direction of specific immune responses. Chemokine action is mediated by a large super-family of G-protein coupled receptors, and the receptors are preferentially expressed on Th1/Th2 cells. Certain chemokine receptors are constitutively expressed in immune surveying cells such as dendritic cells and naive T cells. The corresponding chemokines are present in normal lymphoid tissues, suggesting a role of chemokines/receptors in cell homing and cell-cell communication in lymphoid tissue that can be an initial step for immune recognition. Thus, comprehension of the chemokine biology in immune responses appears to be fundamental for understanding the pathogenesis of T cell-mediated immune responses. The following review will highlight the current insight into the role of chemokines and their receptors in the cell-mediated immune response, with a special focus on lung diseases.

KW - Cell-cell communication

KW - Chemotactic cytokines

KW - Delayed hypersensitivity

KW - Th1/Th2

UR - http://www.scopus.com/inward/record.url?scp=0035873241&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0035873241&partnerID=8YFLogxK

U2 - 10.1002/jemt.1096

DO - 10.1002/jemt.1096

M3 - Article

C2 - 11340675

AN - SCOPUS:0035873241

VL - 53

SP - 298

EP - 306

JO - Microscopy Research and Technique

JF - Microscopy Research and Technique

SN - 1059-910X

IS - 4

ER -