TY - JOUR
T1 - Ige reactivity to milk components in dogs with cutaneous adverse food reactions
AU - Shimakura, Hidekatsu
AU - Nasukawa, Tadahiro
AU - Uchiyama, Jumpei
AU - Sugimoto, Ryosuke
AU - Imanishi, Ichiro
AU - Oota, Sumire
AU - Mizukami, Keijiro
AU - Fujimura, Masato
AU - Sakaguchi, Masahiro
N1 - Funding Information:
ACKNOWLEDGMENTS. This research was partially supported by a Promotion and Mutual Aid Corporation for Private Schools of Japan, a Grant-in-Aid Matching Fund Subsidy for Private University, and a project grant awarded by the Azabu University Research
Publisher Copyright:
© 2021, Japanese Society of Veterinary Science. All rights reserved.
PY - 2021
Y1 - 2021
N2 - We investigated the IgE reactivity to crude and purified milk antigens in the sera of 112 dogs with cutaneous adverse food reactions (CAFRs). Of the 112 dogs, 33 (29%) had specific IgE for crude milk antigens. In the dogs with milk-specific IgE, IgE reactivity to casein, bovine serum albumin (BSA), α-lactalbumin, β-lactoglobulin, and bovine IgG were 81%, 85%, 39%, 27%, and 35%, respectively. Casein and BSA may be important allergens in dogs with CAFRs. Some canine vaccines contain casein hydrolysate as a stabilizer and the pooled serum with anti-casein IgE showed IgE reactivity to the vaccines containing it. Information about IgE reactivity to casein in dogs with CAFRs could be useful for predicting adverse reactions to the vaccines including casein hydrolysate.
AB - We investigated the IgE reactivity to crude and purified milk antigens in the sera of 112 dogs with cutaneous adverse food reactions (CAFRs). Of the 112 dogs, 33 (29%) had specific IgE for crude milk antigens. In the dogs with milk-specific IgE, IgE reactivity to casein, bovine serum albumin (BSA), α-lactalbumin, β-lactoglobulin, and bovine IgG were 81%, 85%, 39%, 27%, and 35%, respectively. Casein and BSA may be important allergens in dogs with CAFRs. Some canine vaccines contain casein hydrolysate as a stabilizer and the pooled serum with anti-casein IgE showed IgE reactivity to the vaccines containing it. Information about IgE reactivity to casein in dogs with CAFRs could be useful for predicting adverse reactions to the vaccines including casein hydrolysate.
KW - Cow’s milk allergen
KW - Cutaneous adverse food reaction
KW - Dog
KW - IgE
KW - Vaccine
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U2 - 10.1292/jvms.21-0162
DO - 10.1292/jvms.21-0162
M3 - Comment/debate
C2 - 34373420
AN - SCOPUS:85116053990
SN - 0916-7250
VL - 83
SP - 1509
EP - 1512
JO - Journal of Veterinary Medical Science
JF - Journal of Veterinary Medical Science
IS - 10
ER -
