IgE-mediated and age-related bronchial hyperresponsiveness in patients with asthma. Relationship to family history of the disease

Fumihiro Mitsunobu, Takashi Mifune, Yasuhiro Hosaki, Kozo Ashida, Hirofumi Tsugeno, Makoto Okamoto, Seishi Harada, Yoshiro Tanizaki

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Objective: To uncover any differences in the age-related and IgE-mediated pathophysiology of the airways in asthmatics. Methods: We examined the relationship of both IgE-mediated bronchial hyperresponsiveness and the cell content of bronchoalveolar lavage fluid with a family history of asthma in 263 patients with asthma classified according to age at onset. Results: Bronchial hyperresponsiveness decreased significantly as age at onset increased in those without a family history. Responsiveness was significantly higher in patients who were ≥60 years of age at onset who had a family history than in those who did not (P < 0.05). The proportion of lymphocytes in bronchoalveolar lavage fluid was significantly higher in patients between 50 and 59 years old at onset who had a family history than those who did not (P < 0.05). These results suggest that bronchial hyperresponsiveness and the proportion of bronchoalveolar lavage lymphocytes differ according to the presence or absence of a family history, a finding which is closely related to IgE-mediated allergy in elderly patients at onset. Conclusions: Our findings suggest (i) the possibility of asthma induced by non-IgE-mediated allergy in elderly patients and (ii) that bronchial responsiveness is also influenced by IgE-mediated allergy and age at onset.

Original languageEnglish
Pages (from-to)215-220
Number of pages6
JournalAge and Ageing
Volume29
Issue number3
DOIs
Publication statusPublished - 2000

Keywords

  • Asthma
  • Bronchial responsiveness
  • Bronchoalveolar lavage
  • Family history

ASJC Scopus subject areas

  • Ageing
  • Geriatrics and Gerontology

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