IgA nephropathy complicated with X-linked thrombocytopenia

Yuki Kakio, Haruhito A. Uchida, Masashi Kitagawa, Yuka Arata, Ayako Kato, Akiko Inoue-Torii, Norikazu Hinamoto, Ayu Ogawa-Akiyama, Hitoshi Sugiyama, Jun Wada

Research output: Contribution to journalArticlepeer-review

Abstract

Renal involvement is occasionally observed in Wiskott-Aldrich syndrome (WAS) and X-linked thrombocytopenia (XLT). It has been reported that galactose-deficient IgA is a closely linked to IgA nephropathy (IgAN), suggesting that patients with XLT/WAS associated with reduced galactosylation on serum IgA are susceptible to IgAN. It is necessary to pay more attention to patients with IgAN due to the potential complication with XLT/WAS. We here present a patient of XLT complicated with mild IgAN who underwent tonsillectomy combined with steroid pulse therapy to achieve complete clinical remission.

Original languageEnglish
Pages (from-to)301-307
Number of pages7
JournalActa medica Okayama
Volume72
Issue number3
Publication statusPublished - 2018

Keywords

  • Galactose-deficient IgA1
  • IgAN nephropathy
  • Wiskott-Aldrich syndrome
  • X-linked thrombocytopenia

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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