IgA nephropathy complicated with X-linked thrombocytopenia

Yuki Kakio; Haruhito A. Uchida; Masashi Kitagawa; Yuka Arata; Ayako Kato; Akiko Inoue-Torii; Norikazu Hinamoto; Ayu Ogawa-Akiyama; Hitoshi Sugiyama; Jun Wada

IgA nephropathy complicated with X-linked thrombocytopenia

Yuki Kakio, Haruhito A. Uchida, Masashi Kitagawa, Yuka Arata, Ayako Kato, Akiko Inoue-Torii, Norikazu Hinamoto, Ayu Ogawa-Akiyama, Hitoshi Sugiyama, Jun Wada

Research output: Contribution to journal › Article › peer-review

Abstract

Renal involvement is occasionally observed in Wiskott-Aldrich syndrome (WAS) and X-linked thrombocytopenia (XLT). It has been reported that galactose-deficient IgA is a closely linked to IgA nephropathy (IgAN), suggesting that patients with XLT/WAS associated with reduced galactosylation on serum IgA are susceptible to IgAN. It is necessary to pay more attention to patients with IgAN due to the potential complication with XLT/WAS. We here present a patient of XLT complicated with mild IgAN who underwent tonsillectomy combined with steroid pulse therapy to achieve complete clinical remission.

Original language	English
Pages (from-to)	301-307
Number of pages	7
Journal	Acta medica Okayama
Volume	72
Issue number	3
Publication status	Published - 2018

Keywords

Galactose-deficient IgA1
IgAN nephropathy
Wiskott-Aldrich syndrome
X-linked thrombocytopenia

ASJC Scopus subject areas

Biochemistry, Genetics and Molecular Biology(all)

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title = "IgA nephropathy complicated with X-linked thrombocytopenia",

abstract = "Renal involvement is occasionally observed in Wiskott-Aldrich syndrome (WAS) and X-linked thrombocytopenia (XLT). It has been reported that galactose-deficient IgA is a closely linked to IgA nephropathy (IgAN), suggesting that patients with XLT/WAS associated with reduced galactosylation on serum IgA are susceptible to IgAN. It is necessary to pay more attention to patients with IgAN due to the potential complication with XLT/WAS. We here present a patient of XLT complicated with mild IgAN who underwent tonsillectomy combined with steroid pulse therapy to achieve complete clinical remission.",

keywords = "Galactose-deficient IgA1, IgAN nephropathy, Wiskott-Aldrich syndrome, X-linked thrombocytopenia",

author = "Yuki Kakio and Uchida, {Haruhito A.} and Masashi Kitagawa and Yuka Arata and Ayako Kato and Akiko Inoue-Torii and Norikazu Hinamoto and Ayu Ogawa-Akiyama and Hitoshi Sugiyama and Jun Wada",

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T1 - IgA nephropathy complicated with X-linked thrombocytopenia

AU - Kakio, Yuki

AU - Uchida, Haruhito A.

AU - Kitagawa, Masashi

AU - Arata, Yuka

AU - Kato, Ayako

AU - Inoue-Torii, Akiko

AU - Hinamoto, Norikazu

AU - Ogawa-Akiyama, Ayu

AU - Sugiyama, Hitoshi

AU - Wada, Jun

PY - 2018

Y1 - 2018

N2 - Renal involvement is occasionally observed in Wiskott-Aldrich syndrome (WAS) and X-linked thrombocytopenia (XLT). It has been reported that galactose-deficient IgA is a closely linked to IgA nephropathy (IgAN), suggesting that patients with XLT/WAS associated with reduced galactosylation on serum IgA are susceptible to IgAN. It is necessary to pay more attention to patients with IgAN due to the potential complication with XLT/WAS. We here present a patient of XLT complicated with mild IgAN who underwent tonsillectomy combined with steroid pulse therapy to achieve complete clinical remission.

AB - Renal involvement is occasionally observed in Wiskott-Aldrich syndrome (WAS) and X-linked thrombocytopenia (XLT). It has been reported that galactose-deficient IgA is a closely linked to IgA nephropathy (IgAN), suggesting that patients with XLT/WAS associated with reduced galactosylation on serum IgA are susceptible to IgAN. It is necessary to pay more attention to patients with IgAN due to the potential complication with XLT/WAS. We here present a patient of XLT complicated with mild IgAN who underwent tonsillectomy combined with steroid pulse therapy to achieve complete clinical remission.

KW - Galactose-deficient IgA1

KW - IgAN nephropathy

KW - Wiskott-Aldrich syndrome

KW - X-linked thrombocytopenia

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