Abstract
Objective. To search for a possible relationship between the presence of IgA class anti-β2-glycoprotein I antibody (aβ2-GPI) and clinical manifestations, including thrombotic episodes, in patients with systemic lupus erythematosus (SLE). Methods. Serum IgA aβ2-GPI levels in 124 Japanese patients with SLE were measured using a phospholipid independent enzyme immunoassay. Relationships to clinical histories and to various laboratory data including IgG and IgM class aβ2-GPI were examined. Results. Twenty-five percent of patients with SLE were positive for IgA aβ2-GPI. Patients with a history of thrombosis had significantly higher probabilities for positivity of IgA aβ2-GPI, compared to those without. The presence of IgA aβ2-GPI was correlated with presence of lupus anticoagulant and/or biological false positive result for serological syphilis test. Titer of IgA aβ2-GPI significantly correlated with values of IgG aβ2-GPI, IgM aβ2- GPI, and anti-DNA antibodies. Conclusion. The presence of IgA aβ2-GPI may be related to the occurrence of thrombosis in patients with SLE. Measurements of IgA aβ2-GPI may be of value for evaluating risk of thrombosis in patients with SLE.
| Original language | English |
|---|---|
| Pages (from-to) | 74-78 |
| Number of pages | 5 |
| Journal | Journal of Rheumatology |
| Volume | 25 |
| Issue number | 1 |
| Publication status | Published - Jan 1998 |
| Externally published | Yes |
Fingerprint
Keywords
- β-glycoprotein I
- Anticardiolipin antibody
- IgA
- Systemic lupus erythematosus
ASJC Scopus subject areas
- Rheumatology
- Immunology
Cite this
IgA class anti-β2-glycoprotein I in patients with systemic lupus erythematosus. / Tsutsumi, Akito; Matsuura, Eiji; Ichikawa, Kenji; Fujisaku, Atsushi; Mukai, Masaya; Koike, Takao.
In: Journal of Rheumatology, Vol. 25, No. 1, 01.1998, p. 74-78.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - IgA class anti-β2-glycoprotein I in patients with systemic lupus erythematosus
AU - Tsutsumi, Akito
AU - Matsuura, Eiji
AU - Ichikawa, Kenji
AU - Fujisaku, Atsushi
AU - Mukai, Masaya
AU - Koike, Takao
PY - 1998/1
Y1 - 1998/1
N2 - Objective. To search for a possible relationship between the presence of IgA class anti-β2-glycoprotein I antibody (aβ2-GPI) and clinical manifestations, including thrombotic episodes, in patients with systemic lupus erythematosus (SLE). Methods. Serum IgA aβ2-GPI levels in 124 Japanese patients with SLE were measured using a phospholipid independent enzyme immunoassay. Relationships to clinical histories and to various laboratory data including IgG and IgM class aβ2-GPI were examined. Results. Twenty-five percent of patients with SLE were positive for IgA aβ2-GPI. Patients with a history of thrombosis had significantly higher probabilities for positivity of IgA aβ2-GPI, compared to those without. The presence of IgA aβ2-GPI was correlated with presence of lupus anticoagulant and/or biological false positive result for serological syphilis test. Titer of IgA aβ2-GPI significantly correlated with values of IgG aβ2-GPI, IgM aβ2- GPI, and anti-DNA antibodies. Conclusion. The presence of IgA aβ2-GPI may be related to the occurrence of thrombosis in patients with SLE. Measurements of IgA aβ2-GPI may be of value for evaluating risk of thrombosis in patients with SLE.
AB - Objective. To search for a possible relationship between the presence of IgA class anti-β2-glycoprotein I antibody (aβ2-GPI) and clinical manifestations, including thrombotic episodes, in patients with systemic lupus erythematosus (SLE). Methods. Serum IgA aβ2-GPI levels in 124 Japanese patients with SLE were measured using a phospholipid independent enzyme immunoassay. Relationships to clinical histories and to various laboratory data including IgG and IgM class aβ2-GPI were examined. Results. Twenty-five percent of patients with SLE were positive for IgA aβ2-GPI. Patients with a history of thrombosis had significantly higher probabilities for positivity of IgA aβ2-GPI, compared to those without. The presence of IgA aβ2-GPI was correlated with presence of lupus anticoagulant and/or biological false positive result for serological syphilis test. Titer of IgA aβ2-GPI significantly correlated with values of IgG aβ2-GPI, IgM aβ2- GPI, and anti-DNA antibodies. Conclusion. The presence of IgA aβ2-GPI may be related to the occurrence of thrombosis in patients with SLE. Measurements of IgA aβ2-GPI may be of value for evaluating risk of thrombosis in patients with SLE.
KW - β-glycoprotein I
KW - Anticardiolipin antibody
KW - IgA
KW - Systemic lupus erythematosus
UR - http://www.scopus.com/inward/record.url?scp=0031975559&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0031975559&partnerID=8YFLogxK
M3 - Article
C2 - 9458206
AN - SCOPUS:0031975559
VL - 25
SP - 74
EP - 78
JO - Journal of Rheumatology
JF - Journal of Rheumatology
SN - 0315-162X
IS - 1
ER -