IgA class anti-β2-glycoprotein I in patients with systemic lupus erythematosus

Akito Tsutsumi, Eiji Matsuura, Kenji Ichikawa, Atsushi Fujisaku, Masaya Mukai, Takao Koike

Research output: Contribution to journalArticlepeer-review

48 Citations (Scopus)


Objective. To search for a possible relationship between the presence of IgA class anti-β2-glycoprotein I antibody (aβ2-GPI) and clinical manifestations, including thrombotic episodes, in patients with systemic lupus erythematosus (SLE). Methods. Serum IgA aβ2-GPI levels in 124 Japanese patients with SLE were measured using a phospholipid independent enzyme immunoassay. Relationships to clinical histories and to various laboratory data including IgG and IgM class aβ2-GPI were examined. Results. Twenty-five percent of patients with SLE were positive for IgA aβ2-GPI. Patients with a history of thrombosis had significantly higher probabilities for positivity of IgA aβ2-GPI, compared to those without. The presence of IgA aβ2-GPI was correlated with presence of lupus anticoagulant and/or biological false positive result for serological syphilis test. Titer of IgA aβ2-GPI significantly correlated with values of IgG aβ2-GPI, IgM aβ2- GPI, and anti-DNA antibodies. Conclusion. The presence of IgA aβ2-GPI may be related to the occurrence of thrombosis in patients with SLE. Measurements of IgA aβ2-GPI may be of value for evaluating risk of thrombosis in patients with SLE.

Original languageEnglish
Pages (from-to)74-78
Number of pages5
JournalJournal of Rheumatology
Issue number1
Publication statusPublished - Jan 1998
Externally publishedYes


  • Anticardiolipin antibody
  • IgA
  • Systemic lupus erythematosus
  • β-glycoprotein I

ASJC Scopus subject areas

  • Rheumatology
  • Immunology and Allergy
  • Immunology


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