Abstract
Objective. To search for a possible relationship between the presence of IgA class anti-β2-glycoprotein I antibody (aβ2-GPI) and clinical manifestations, including thrombotic episodes, in patients with systemic lupus erythematosus (SLE). Methods. Serum IgA aβ2-GPI levels in 124 Japanese patients with SLE were measured using a phospholipid independent enzyme immunoassay. Relationships to clinical histories and to various laboratory data including IgG and IgM class aβ2-GPI were examined. Results. Twenty-five percent of patients with SLE were positive for IgA aβ2-GPI. Patients with a history of thrombosis had significantly higher probabilities for positivity of IgA aβ2-GPI, compared to those without. The presence of IgA aβ2-GPI was correlated with presence of lupus anticoagulant and/or biological false positive result for serological syphilis test. Titer of IgA aβ2-GPI significantly correlated with values of IgG aβ2-GPI, IgM aβ2- GPI, and anti-DNA antibodies. Conclusion. The presence of IgA aβ2-GPI may be related to the occurrence of thrombosis in patients with SLE. Measurements of IgA aβ2-GPI may be of value for evaluating risk of thrombosis in patients with SLE.
Original language | English |
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Pages (from-to) | 74-78 |
Number of pages | 5 |
Journal | Journal of Rheumatology |
Volume | 25 |
Issue number | 1 |
Publication status | Published - Jan 1998 |
Externally published | Yes |
Keywords
- Anticardiolipin antibody
- IgA
- Systemic lupus erythematosus
- β-glycoprotein I
ASJC Scopus subject areas
- Rheumatology
- Immunology and Allergy
- Immunology