IgA class anti-β2-glycoprotein I in patients with systemic lupus erythematosus

Akito Tsutsumi, Eiji Matsuura, Kenji Ichikawa, Atsushi Fujisaku, Masaya Mukai, Takao Koike

Research output: Contribution to journalArticle

45 Citations (Scopus)

Abstract

Objective. To search for a possible relationship between the presence of IgA class anti-β2-glycoprotein I antibody (aβ2-GPI) and clinical manifestations, including thrombotic episodes, in patients with systemic lupus erythematosus (SLE). Methods. Serum IgA aβ2-GPI levels in 124 Japanese patients with SLE were measured using a phospholipid independent enzyme immunoassay. Relationships to clinical histories and to various laboratory data including IgG and IgM class aβ2-GPI were examined. Results. Twenty-five percent of patients with SLE were positive for IgA aβ2-GPI. Patients with a history of thrombosis had significantly higher probabilities for positivity of IgA aβ2-GPI, compared to those without. The presence of IgA aβ2-GPI was correlated with presence of lupus anticoagulant and/or biological false positive result for serological syphilis test. Titer of IgA aβ2-GPI significantly correlated with values of IgG aβ2-GPI, IgM aβ2- GPI, and anti-DNA antibodies. Conclusion. The presence of IgA aβ2-GPI may be related to the occurrence of thrombosis in patients with SLE. Measurements of IgA aβ2-GPI may be of value for evaluating risk of thrombosis in patients with SLE.

Original languageEnglish
Pages (from-to)74-78
Number of pages5
JournalJournal of Rheumatology
Volume25
Issue number1
Publication statusPublished - Jan 1998
Externally publishedYes

Fingerprint

Systemic Lupus Erythematosus
Glycoproteins
Antibodies
Thrombosis
anti-IgA
Lupus Coagulation Inhibitor
Antinuclear Antibodies
Serologic Tests
Syphilis
Immunoenzyme Techniques
Immunoglobulin M
Phospholipids
Immunoglobulin G
Serum

Keywords

  • β-glycoprotein I
  • Anticardiolipin antibody
  • IgA
  • Systemic lupus erythematosus

ASJC Scopus subject areas

  • Rheumatology
  • Immunology

Cite this

Tsutsumi, A., Matsuura, E., Ichikawa, K., Fujisaku, A., Mukai, M., & Koike, T. (1998). IgA class anti-β2-glycoprotein I in patients with systemic lupus erythematosus. Journal of Rheumatology, 25(1), 74-78.

IgA class anti-β2-glycoprotein I in patients with systemic lupus erythematosus. / Tsutsumi, Akito; Matsuura, Eiji; Ichikawa, Kenji; Fujisaku, Atsushi; Mukai, Masaya; Koike, Takao.

In: Journal of Rheumatology, Vol. 25, No. 1, 01.1998, p. 74-78.

Research output: Contribution to journalArticle

Tsutsumi, A, Matsuura, E, Ichikawa, K, Fujisaku, A, Mukai, M & Koike, T 1998, 'IgA class anti-β2-glycoprotein I in patients with systemic lupus erythematosus', Journal of Rheumatology, vol. 25, no. 1, pp. 74-78.
Tsutsumi A, Matsuura E, Ichikawa K, Fujisaku A, Mukai M, Koike T. IgA class anti-β2-glycoprotein I in patients with systemic lupus erythematosus. Journal of Rheumatology. 1998 Jan;25(1):74-78.
Tsutsumi, Akito ; Matsuura, Eiji ; Ichikawa, Kenji ; Fujisaku, Atsushi ; Mukai, Masaya ; Koike, Takao. / IgA class anti-β2-glycoprotein I in patients with systemic lupus erythematosus. In: Journal of Rheumatology. 1998 ; Vol. 25, No. 1. pp. 74-78.
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