Identify LD blocks based on hierarchical spatial data

Makoto Tomita, Masahiro Hatsumichi, Koji Kurihara

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

A domain where recombination does not occur often, yet maintained linkage disequilibrium exists on DNA sequence is known as a "haplotype block" or "LD block". Many methods are available to identify LD blocks using disequilibrium parameters, such as the well-known Gabriel's method, Zhu's method and so on. We considered that Echelon analysis can be applied to identify LD block, and report herein that LD blocks can be identified according to our new method applying Echelon analysis. The results of numerical examples are also provided.

Original languageEnglish
Pages (from-to)1806-1820
Number of pages15
JournalComputational Statistics and Data Analysis
Volume52
Issue number4
DOIs
Publication statusPublished - Jan 10 2008

Keywords

  • Echelon analysis
  • Haplotype block
  • LD block
  • SNPs

ASJC Scopus subject areas

  • Statistics and Probability
  • Computational Mathematics
  • Computational Theory and Mathematics
  • Applied Mathematics

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