Identify LD blocks based on hierarchical spatial data

Makoto Tomita, Masahiro Hatsumichi, Koji Kurihara

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

A domain where recombination does not occur often, yet maintained linkage disequilibrium exists on DNA sequence is known as a "haplotype block" or "LD block". Many methods are available to identify LD blocks using disequilibrium parameters, such as the well-known Gabriel's method, Zhu's method and so on. We considered that Echelon analysis can be applied to identify LD block, and report herein that LD blocks can be identified according to our new method applying Echelon analysis. The results of numerical examples are also provided.

Original languageEnglish
Pages (from-to)1806-1820
Number of pages15
JournalComputational Statistics and Data Analysis
Volume52
Issue number4
DOIs
Publication statusPublished - Jan 10 2008

Fingerprint

Hierarchical Data
DNA sequences
Spatial Data
Linkage Disequilibrium
Haplotype
Recombination
DNA Sequence
Numerical Examples
Disequilibrium

Keywords

  • Echelon analysis
  • Haplotype block
  • LD block
  • SNPs

ASJC Scopus subject areas

  • Computational Theory and Mathematics
  • Statistics, Probability and Uncertainty
  • Electrical and Electronic Engineering
  • Computational Mathematics
  • Numerical Analysis
  • Statistics and Probability

Cite this

Identify LD blocks based on hierarchical spatial data. / Tomita, Makoto; Hatsumichi, Masahiro; Kurihara, Koji.

In: Computational Statistics and Data Analysis, Vol. 52, No. 4, 10.01.2008, p. 1806-1820.

Research output: Contribution to journalArticle

Tomita, Makoto ; Hatsumichi, Masahiro ; Kurihara, Koji. / Identify LD blocks based on hierarchical spatial data. In: Computational Statistics and Data Analysis. 2008 ; Vol. 52, No. 4. pp. 1806-1820.
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