Identification of unique thyrotropin receptor (TSHR) splice variants in the chicken: The chicken TSHR gene revisited

Sylvia V.H. Grommen, Shusuke Taniuchi, Veerle M. Darras, Sumio Takahashi, Sakae Takeuchi, Bert De Groef

Research output: Contribution to journalArticlepeer-review

4 Citations (Scopus)

Abstract

We previously described the cloning of the full-length chicken thyrotropin receptor (TSHRa) and two splice variants, lacking exon 3 (TSHRb) or both exons 2 and 3 (TSHRc). Here we report the identification of three novel splice variants of the chicken TSHR, named TSHRd, -e and -f, differing in their C-terminal region and containing unique exonic sequences that are not present in the other TSHR variants. This finding suggests a TSHR gene structure with 13 rather than the previously assumed 10 exons. The three novel exons appear to be chicken-specific, as no equivalents of these exons were found in other vertebrate genomes. Like the full-length receptor, the five TSHR splice variants are most abundantly expressed in thyroid gland. TSHRb, -d, -e and -f mRNA was also present in virtually all extra-thyroidal tissues expressing TSHRa, whereas TSHRc shows a more restricted tissue distribution. Whether these receptor transcripts are translated to functional proteins needs to be verified, but if so, they could be attributed various physiological roles.

Original languageEnglish
Pages (from-to)460-463
Number of pages4
JournalGeneral and Comparative Endocrinology
Volume156
Issue number3
DOIs
Publication statusPublished - May 1 2008

Keywords

  • Alternative splicing
  • Chicken
  • Gene structure
  • Thyrotropin receptor

ASJC Scopus subject areas

  • Animal Science and Zoology
  • Endocrinology

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