Identification of two subtypes of protein kinase C in human placenta

Seiji Nomura, Hiroshi Tokumitsu, Shigehiko Mizutani, Osamu Narita, Yutaka Tomada, Hiroyoshi Hidaka

Research output: Contribution to journalArticlepeer-review

9 Citations (Scopus)


A purified protein kinase C (PKC) has been isolated from term human placental tissue, which is phospholipid and Ca2+-dependent. Two subtypes of the enzyme were identified by hydroxyapatite column chromatography and using monoclonal antibodies with immunohistochemical techniques; subtype III is present in higher concentration than subtype II. Their ratio of 2.5 is very similar in second and third trimester placentas, but is higher, 6.5, in the first trimester. The subtype I was never expressed.

Original languageEnglish
Pages (from-to)605-613
Number of pages9
Issue number6
Publication statusPublished - Jan 1 1991
Externally publishedYes

ASJC Scopus subject areas

  • Reproductive Medicine
  • Obstetrics and Gynaecology
  • Developmental Biology


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