Identification of novel epoxide inhibitors of hepatitis C virus replication using a high-throughput screen

Lee F. Peng, Suk Kim Sun, Sirinya Matchacheep, Xiaoguang Lei, Shun Su, Wenyu Lin, Weerawat Runguphan, Won Hyeok Choe, Naoya Sakamoto, Masanori Ikeda, Nobuyuki Kato, Aaron B. Beeler, John A. Porco, Stuart L. Schreiber, Raymond T. Chung

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Using our high-throughput hepatitis C replicon assay to screen a library of over 8,000 novel diversity-oriented synthesis (DOS) compounds, we identified several novel compounds that regulate hepatitis C virus (HCV) replication, including two libraries of epoxides that inhibit HCV replication (best 50% effective concentration, < 0.5 μM). We then synthesized an analog of these compounds with optimized activity.

Original languageEnglish
Pages (from-to)3756-3759
Number of pages4
JournalAntimicrobial Agents and Chemotherapy
Volume51
Issue number10
DOIs
Publication statusPublished - Oct 2007

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)
  • Infectious Diseases

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    Peng, L. F., Sun, S. K., Matchacheep, S., Lei, X., Su, S., Lin, W., Runguphan, W., Choe, W. H., Sakamoto, N., Ikeda, M., Kato, N., Beeler, A. B., Porco, J. A., Schreiber, S. L., & Chung, R. T. (2007). Identification of novel epoxide inhibitors of hepatitis C virus replication using a high-throughput screen. Antimicrobial Agents and Chemotherapy, 51(10), 3756-3759. https://doi.org/10.1128/AAC.00233-07