Identification of high-risk syncope related to ventricular fibrillation in patients with Brugada syndrome

Yutaka Take; Hiroshi Morita; Norihisa Toh; Nobuhiro Nishii; Satoshi Nagase; Kazufumi Nakamura; Kengo F. Kusano; Tohru Ohe; Hiroshi Itoh

doi:10.1016/j.hrthm.2011.11.045

Identification of high-risk syncope related to ventricular fibrillation in patients with Brugada syndrome

Yutaka Take, Hiroshi Morita, Norihisa Toh, Nobuhiro Nishii, Satoshi Nagase, Kazufumi Nakamura, Kengo F. Kusano, Tohru Ohe, Hiroshi Itoh

Research output: Contribution to journal › Article

44 Citations (Scopus)

Abstract

BACKGROUND: Syncope in patients with Brugada syndrome is usually associated with ventricular tachyarrhythmia, but some episodes of syncope can be related to autonomic disorders. OBJECTIVE: The purpose of this study was to investigate the characteristics of syncope to differentiate high-risk syncope episodes from low-risk events in patients with Brugada syndrome. METHODS: We studied 84 patients with type 1 electrocardiogram and syncope. Patients were divided into 2 groups: patients with prodrome (prodromal group; n = 41) and patients without prodrome (nonprodromal group; n = 43). RESULTS: Ventricular fibrillation (VF) was documented at index event in 19 patients: 4 patients (21%) with documented VF experienced a prodrome prior to the onset of VF, whereas 15 patients (79%) did not have symptoms prior to documented VF (P

Original language	English
Pages (from-to)	752-759
Number of pages	8
Journal	Heart Rhythm
Volume	9
Issue number	5
DOIs	https://doi.org/10.1016/j.hrthm.2011.11.045
Publication status	Published - May 2012

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Keywords

Brugada syndrome
Neurally mediated syncope
Prodrome
Syncope
Ventricular fibrillation

ASJC Scopus subject areas

Cardiology and Cardiovascular Medicine
Physiology (medical)

Cite this

Take, Y., Morita, H., Toh, N., Nishii, N., Nagase, S., Nakamura, K., Kusano, K. F., Ohe, T., & Itoh, H. (2012). Identification of high-risk syncope related to ventricular fibrillation in patients with Brugada syndrome. Heart Rhythm, 9(5), 752-759. https://doi.org/10.1016/j.hrthm.2011.11.045

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title = "Identification of high-risk syncope related to ventricular fibrillation in patients with Brugada syndrome",

abstract = "BACKGROUND: Syncope in patients with Brugada syndrome is usually associated with ventricular tachyarrhythmia, but some episodes of syncope can be related to autonomic disorders. OBJECTIVE: The purpose of this study was to investigate the characteristics of syncope to differentiate high-risk syncope episodes from low-risk events in patients with Brugada syndrome. METHODS: We studied 84 patients with type 1 electrocardiogram and syncope. Patients were divided into 2 groups: patients with prodrome (prodromal group; n = 41) and patients without prodrome (nonprodromal group; n = 43). RESULTS: Ventricular fibrillation (VF) was documented at index event in 19 patients: 4 patients (21%) with documented VF experienced a prodrome prior to the onset of VF, whereas 15 patients (79%) did not have symptoms prior to documented VF (P ",

keywords = "Brugada syndrome, Neurally mediated syncope, Prodrome, Syncope, Ventricular fibrillation",

author = "Yutaka Take and Hiroshi Morita and Norihisa Toh and Nobuhiro Nishii and Satoshi Nagase and Kazufumi Nakamura and Kusano, {Kengo F.} and Tohru Ohe and Hiroshi Itoh",

year = "2012",

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AU - Take, Yutaka

AU - Morita, Hiroshi

AU - Toh, Norihisa

AU - Nishii, Nobuhiro

AU - Nagase, Satoshi

AU - Nakamura, Kazufumi

AU - Kusano, Kengo F.

AU - Ohe, Tohru

AU - Itoh, Hiroshi

PY - 2012/5

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N2 - BACKGROUND: Syncope in patients with Brugada syndrome is usually associated with ventricular tachyarrhythmia, but some episodes of syncope can be related to autonomic disorders. OBJECTIVE: The purpose of this study was to investigate the characteristics of syncope to differentiate high-risk syncope episodes from low-risk events in patients with Brugada syndrome. METHODS: We studied 84 patients with type 1 electrocardiogram and syncope. Patients were divided into 2 groups: patients with prodrome (prodromal group; n = 41) and patients without prodrome (nonprodromal group; n = 43). RESULTS: Ventricular fibrillation (VF) was documented at index event in 19 patients: 4 patients (21%) with documented VF experienced a prodrome prior to the onset of VF, whereas 15 patients (79%) did not have symptoms prior to documented VF (P

AB - BACKGROUND: Syncope in patients with Brugada syndrome is usually associated with ventricular tachyarrhythmia, but some episodes of syncope can be related to autonomic disorders. OBJECTIVE: The purpose of this study was to investigate the characteristics of syncope to differentiate high-risk syncope episodes from low-risk events in patients with Brugada syndrome. METHODS: We studied 84 patients with type 1 electrocardiogram and syncope. Patients were divided into 2 groups: patients with prodrome (prodromal group; n = 41) and patients without prodrome (nonprodromal group; n = 43). RESULTS: Ventricular fibrillation (VF) was documented at index event in 19 patients: 4 patients (21%) with documented VF experienced a prodrome prior to the onset of VF, whereas 15 patients (79%) did not have symptoms prior to documented VF (P

KW - Brugada syndrome

KW - Neurally mediated syncope

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KW - Syncope

KW - Ventricular fibrillation

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10.1016/j.hrthm.2011.11.045