Identification of high-risk syncope related to ventricular fibrillation in patients with Brugada syndrome

Yutaka Take, Hiroshi Morita, Norihisa Toh, Nobuhiro Nishii, Satoshi Nagase, Kazufumi Nakamura, Kengo F. Kusano, Tohru Ohe, Hiroshi Itoh

Research output: Contribution to journalArticle

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Abstract

BACKGROUND: Syncope in patients with Brugada syndrome is usually associated with ventricular tachyarrhythmia, but some episodes of syncope can be related to autonomic disorders. OBJECTIVE: The purpose of this study was to investigate the characteristics of syncope to differentiate high-risk syncope episodes from low-risk events in patients with Brugada syndrome. METHODS: We studied 84 patients with type 1 electrocardiogram and syncope. Patients were divided into 2 groups: patients with prodrome (prodromal group; n = 41) and patients without prodrome (nonprodromal group; n = 43). RESULTS: Ventricular fibrillation (VF) was documented at index event in 19 patients: 4 patients (21%) with documented VF experienced a prodrome prior to the onset of VF, whereas 15 patients (79%) did not have symptoms prior to documented VF (P

Original languageEnglish
Pages (from-to)752-759
Number of pages8
JournalHeart Rhythm
Volume9
Issue number5
DOIs
Publication statusPublished - May 2012

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Keywords

  • Brugada syndrome
  • Neurally mediated syncope
  • Prodrome
  • Syncope
  • Ventricular fibrillation

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Physiology (medical)

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