Identification of genes expressed preferentially in the honeybee mushroom bodies by combination of differential display and cDNA microarray

Hideaki Takeuchi, Tomoko Fujiyuki, Kenichi Shirai, Yuko Matsuo, Azusa Kamikouchi, Yumi Fujinawa, Azusa Kato, Atsumi Tsujimoto, Takeo Kubo

Research output: Contribution to journal › Article

44 Citations (Scopus)

Abstract

To clarify the molecular basis underlying the neural function of the honeybee mushroom bodies (MBs), we identified three genes preferentially expressed in MB using cDNA microarrays containing 480 differential display-positive candidate cDNAs expressed locally or differentially, dependent on caste/aggressive behavior in the honeybee brain. One of the cDNAs encodes a putative type I inositol 1,4,5-trisphosphate (IP3) 5-phosphatase and was expressed preferentially in one of two types of intrinsic MB neurons, the large-type Kenyon cells, suggesting that IP3-mediated Ca2+ signaling is enhanced in these neurons.

Original languageEnglish
Pages (from-to)230-234
Number of pages5
JournalFEBS Letters
Volume513
Issue number2-3
DOIs
Publication statusPublished - Feb 27 2002

Keywords

  • Brain
  • Differential display
  • Honeybee
  • Inositol 1,4,5-trisphosphate 5-phosphatase
  • Mushroom body
  • cDNA microarray

ASJC Scopus subject areas

  • Biophysics
  • Structural Biology
  • Biochemistry
  • Molecular Biology
  • Genetics
  • Cell Biology

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    Takeuchi, H., Fujiyuki, T., Shirai, K., Matsuo, Y., Kamikouchi, A., Fujinawa, Y., Kato, A., Tsujimoto, A., & Kubo, T. (2002). Identification of genes expressed preferentially in the honeybee mushroom bodies by combination of differential display and cDNA microarray. FEBS Letters, 513(2-3), 230-234. https://doi.org/10.1016/S0014-5793(02)02319-0