Identification of Caspase-6 as a Candidate Tumor Suppressor Gene at 4q25 in Oral Cancer

Yasuo Shinno; Mehmet Gunduz; Esra Gunduz; Kenji Shimizu; Masahiro Yoshiyama; Noriyuki Nagai; Akira Yasuoka

doi:10.2485/jhtb.14.328

Identification of Caspase-6 as a Candidate Tumor Suppressor Gene at 4q25 in Oral Cancer

Yasuo Shinno, Mehmet Gunduz, Esra Gunduz, Kenji Shimizu, Masahiro Yoshiyama, Noriyuki Nagai, Akira Yasuoka

Research output: Contribution to journal › Article › peer-review

Abstract

We recently reported the frequent deletion of chromosome 4q25 region in oral squamous cell carcinoma and discussed the Caspase-6 as a possible tumor suppressor gene in this region due to its near location to this hot spot. We this time examined the role of Caspase-6 in oral cancers. mRNA expression level, protein localization and gene mutation of Caspase-6 were analyzed. Reverse-transcription-PCR analysis demonstrated decreased expression in 40% and equal expression in 30% of Caspase-6 mRNA of primary tumors as compared with that matched normal samples. cDNA sequencing analysis of Caspase-6 did not reveal any somatic mutation. Caspase-6 protein localization was in similar proportion with its mRNA expression. Failure of Caspase-6 response in tumor samples as compared to normal samples could suggest Caspase-6 as a candidate tumor suppressor gene in a subset of oral cancer.

Original language	English
Pages (from-to)	328-329
Number of pages	2
Journal	Journal of Hard Tissue Biology
Volume	14
Issue number	2
DOIs	https://doi.org/10.2485/jhtb.14.328
Publication status	Published - Jan 2005

ASJC Scopus subject areas

Medicine (miscellaneous)
Biochemistry
Biomaterials
Orthopedics and Sports Medicine
Dentistry(all)
Cell Biology

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title = "Identification of Caspase-6 as a Candidate Tumor Suppressor Gene at 4q25 in Oral Cancer",

abstract = "We recently reported the frequent deletion of chromosome 4q25 region in oral squamous cell carcinoma and discussed the Caspase-6 as a possible tumor suppressor gene in this region due to its near location to this hot spot. We this time examined the role of Caspase-6 in oral cancers. mRNA expression level, protein localization and gene mutation of Caspase-6 were analyzed. Reverse-transcription-PCR analysis demonstrated decreased expression in 40% and equal expression in 30% of Caspase-6 mRNA of primary tumors as compared with that matched normal samples. cDNA sequencing analysis of Caspase-6 did not reveal any somatic mutation. Caspase-6 protein localization was in similar proportion with its mRNA expression. Failure of Caspase-6 response in tumor samples as compared to normal samples could suggest Caspase-6 as a candidate tumor suppressor gene in a subset of oral cancer.",

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AU - Shinno, Yasuo

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AU - Gunduz, Esra

AU - Shimizu, Kenji

AU - Yoshiyama, Masahiro

AU - Nagai, Noriyuki

AU - Yasuoka, Akira

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Identification of Caspase-6 as a Candidate Tumor Suppressor Gene at 4q25 in Oral Cancer

Abstract

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