Abstract
We recently reported the frequent deletion of chromosome 4q25 region in oral squamous cell carcinoma and discussed the Caspase-6 as a possible tumor suppressor gene in this region due to its near location to this hot spot. We this time examined the role of Caspase-6 in oral cancers. mRNA expression level, protein localization and gene mutation of Caspase-6 were analyzed. Reverse-transcription-PCR analysis demonstrated decreased expression in 40% and equal expression in 30% of Caspase-6 mRNA of primary tumors as compared with that matched normal samples. cDNA sequencing analysis of Caspase-6 did not reveal any somatic mutation. Caspase-6 protein localization was in similar proportion with its mRNA expression. Failure of Caspase-6 response in tumor samples as compared to normal samples could suggest Caspase-6 as a candidate tumor suppressor gene in a subset of oral cancer.
| Original language | English |
|---|---|
| Pages (from-to) | 328-329 |
| Number of pages | 2 |
| Journal | Journal of Hard Tissue Biology |
| Volume | 14 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - 2005 |
Fingerprint
ASJC Scopus subject areas
- Medicine (miscellaneous)
- Biochemistry
- Biomaterials
- Orthopedics and Sports Medicine
- Dentistry(all)
- Cell Biology
Cite this
Identification of Caspase-6 as a Candidate Tumor Suppressor Gene at 4q25 in Oral Cancer. / Shinno, Yasuo; Gunduz, Mehmet; Gunduz, Esra; Shimizu, Kenji; Yoshiyama, Masahiro; Nagai, Noriyuki; Yasuoka, Akira.
In: Journal of Hard Tissue Biology, Vol. 14, No. 2, 2005, p. 328-329.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Identification of Caspase-6 as a Candidate Tumor Suppressor Gene at 4q25 in Oral Cancer
AU - Shinno, Yasuo
AU - Gunduz, Mehmet
AU - Gunduz, Esra
AU - Shimizu, Kenji
AU - Yoshiyama, Masahiro
AU - Nagai, Noriyuki
AU - Yasuoka, Akira
PY - 2005
Y1 - 2005
N2 - We recently reported the frequent deletion of chromosome 4q25 region in oral squamous cell carcinoma and discussed the Caspase-6 as a possible tumor suppressor gene in this region due to its near location to this hot spot. We this time examined the role of Caspase-6 in oral cancers. mRNA expression level, protein localization and gene mutation of Caspase-6 were analyzed. Reverse-transcription-PCR analysis demonstrated decreased expression in 40% and equal expression in 30% of Caspase-6 mRNA of primary tumors as compared with that matched normal samples. cDNA sequencing analysis of Caspase-6 did not reveal any somatic mutation. Caspase-6 protein localization was in similar proportion with its mRNA expression. Failure of Caspase-6 response in tumor samples as compared to normal samples could suggest Caspase-6 as a candidate tumor suppressor gene in a subset of oral cancer.
AB - We recently reported the frequent deletion of chromosome 4q25 region in oral squamous cell carcinoma and discussed the Caspase-6 as a possible tumor suppressor gene in this region due to its near location to this hot spot. We this time examined the role of Caspase-6 in oral cancers. mRNA expression level, protein localization and gene mutation of Caspase-6 were analyzed. Reverse-transcription-PCR analysis demonstrated decreased expression in 40% and equal expression in 30% of Caspase-6 mRNA of primary tumors as compared with that matched normal samples. cDNA sequencing analysis of Caspase-6 did not reveal any somatic mutation. Caspase-6 protein localization was in similar proportion with its mRNA expression. Failure of Caspase-6 response in tumor samples as compared to normal samples could suggest Caspase-6 as a candidate tumor suppressor gene in a subset of oral cancer.
UR - http://www.scopus.com/inward/record.url?scp=85024720927&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85024720927&partnerID=8YFLogxK
U2 - 10.2485/jhtb.14.328
DO - 10.2485/jhtb.14.328
M3 - Article
AN - SCOPUS:85024720927
VL - 14
SP - 328
EP - 329
JO - Journal of Hard Tissue Biology
JF - Journal of Hard Tissue Biology
SN - 1341-7649
IS - 2
ER -