Metabolism of cannabidiol (CBD), one of the major components of marihuana, was studied in the guinea pig both in vitroand in vivoAnalyses of metabolites by gas chromatography and gas chromatography-mass spectrometry proved that cannabielsoin (CBE) was formed from CBD as a novel metabolite, and that the amount was about one-sixth of 7-hydroxy-CBD, which was the most abudant metabolite under in vitroconditions in the presence of microsomal monooxygenase(cyto-chrome P-450). CBE was also found in the liver of the guinea pig that was given CBD (100 mg/kg) in- traperitoneally 1 h before sacrifice. The effects of CBE on pentobarbital-induced sleep and body temperature were assessed in the mouse; CBE possessed little activity in either case.
- in vitro-in vivo metabolite
- monooxygenated metabolite
- pentobarbital-induced sleep prolongation
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