Identification of a src family protein specifically expressed in rat astrocytes by immunohistochemistry and double immunofluorescent study

Lizomar J.M.P. Moia; Hideki Matsui; Hajime Nishio; Takahiro Tsuchida; Masaaki Tokuda; Toshifumi Itano; Seigo Nagao; Osamu Hatase

doi:10.1016/0006-8993(92)91219-5

Identification of a src family protein specifically expressed in rat astrocytes by immunohistochemistry and double immunofluorescent study

Lizomar J.M.P. Moia, Hideki Matsui, Hajime Nishio, Takahiro Tsuchida, Masaaki Tokuda, Toshifumi Itano, Seigo Nagao, Osamu Hatase

Graduate School of Medicine Dentistry and Pharmaceutical Sciences

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Abstract

Identification of a src-related tyrosine kinase and its regional and cellular distributions were studied in rat brain. The study was performed using a specific antibody raised against a synthetic peptide corresponding to the conserved autophosphorylation site of src-family tyrosine kinases. The antibody (α-src antibody) recognized a 43 kDa polypeptide in plasma membrane enriched fraction. The immunohistochemical data revealed that the polypeptide is localized in astrocytes of corpus callosum and fimbria hippocampus. The presence of this src-related protein in astrocytes suggests that it may have some control in their proliferation and differentiation.

Original language	English
Pages (from-to)	283-286
Number of pages	4
Journal	Brain Research
Volume	585
Issue number	1-2
DOIs	https://doi.org/10.1016/0006-8993(92)91219-5
Publication status	Published - Jul 10 1992

Keywords

Astrocyte
Corpus callosum
Double immunofluorescence study
Fimbria hippocampus
Glial cell
Immunohistochemistry
Tyrosine kinase
pp60

ASJC Scopus subject areas

Neuroscience(all)
Molecular Biology
Clinical Neurology
Developmental Biology

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Identification of a src family protein specifically expressed in rat astrocytes by immunohistochemistry and double immunofluorescent study. / Moia, Lizomar J.M.P.; Matsui, Hideki; Nishio, Hajime; Tsuchida, Takahiro; Tokuda, Masaaki; Itano, Toshifumi; Nagao, Seigo; Hatase, Osamu.

In: Brain Research, Vol. 585, No. 1-2, 10.07.1992, p. 283-286.

Research output: Contribution to journal › Article › peer-review

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AU - Moia, Lizomar J.M.P.

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AU - Tsuchida, Takahiro

AU - Tokuda, Masaaki

AU - Itano, Toshifumi

AU - Nagao, Seigo

AU - Hatase, Osamu

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Identification of a src family protein specifically expressed in rat astrocytes by immunohistochemistry and double immunofluorescent study

Abstract

Keywords

ASJC Scopus subject areas

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