Abstract
Identification of a src-related tyrosine kinase and its regional and cellular distributions were studied in rat brain. The study was performed using a specific antibody raised against a synthetic peptide corresponding to the conserved autophosphorylation site of src-family tyrosine kinases. The antibody (α-src antibody) recognized a 43 kDa polypeptide in plasma membrane enriched fraction. The immunohistochemical data revealed that the polypeptide is localized in astrocytes of corpus callosum and fimbria hippocampus. The presence of this src-related protein in astrocytes suggests that it may have some control in their proliferation and differentiation.
| Original language | English |
|---|---|
| Pages (from-to) | 283-286 |
| Number of pages | 4 |
| Journal | Brain Research |
| Volume | 585 |
| Issue number | 1-2 |
| DOIs | |
| Publication status | Published - Jul 10 1992 |
Keywords
- Astrocyte
- Corpus callosum
- Double immunofluorescence study
- Fimbria hippocampus
- Glial cell
- Immunohistochemistry
- Tyrosine kinase
- pp60
ASJC Scopus subject areas
- Neuroscience(all)
- Molecular Biology
- Clinical Neurology
- Developmental Biology
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Cite this
Moia, L. J. M. P., Matsui, H., Nishio, H., Tsuchida, T., Tokuda, M., Itano, T., Nagao, S., & Hatase, O. (1992). Identification of a src family protein specifically expressed in rat astrocytes by immunohistochemistry and double immunofluorescent study. Brain Research, 585(1-2), 283-286. https://doi.org/10.1016/0006-8993(92)91219-5