Identification of a src family protein specifically expressed in rat astrocytes by immunohistochemistry and double immunofluorescent study

Lizomar J.M.P. Moia, Hideki Matsui, Hajime Nishio, Takahiro Tsuchida, Masaaki Tokuda, Toshifumi Itano, Seigo Nagao, Osamu Hatase

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Identification of a src-related tyrosine kinase and its regional and cellular distributions were studied in rat brain. The study was performed using a specific antibody raised against a synthetic peptide corresponding to the conserved autophosphorylation site of src-family tyrosine kinases. The antibody (α-src antibody) recognized a 43 kDa polypeptide in plasma membrane enriched fraction. The immunohistochemical data revealed that the polypeptide is localized in astrocytes of corpus callosum and fimbria hippocampus. The presence of this src-related protein in astrocytes suggests that it may have some control in their proliferation and differentiation.

Original languageEnglish
Pages (from-to)283-286
Number of pages4
JournalBrain Research
Volume585
Issue number1-2
DOIs
Publication statusPublished - Jul 10 1992

Keywords

  • Astrocyte
  • Corpus callosum
  • Double immunofluorescence study
  • Fimbria hippocampus
  • Glial cell
  • Immunohistochemistry
  • Tyrosine kinase
  • pp60

ASJC Scopus subject areas

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

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  • Cite this

    Moia, L. J. M. P., Matsui, H., Nishio, H., Tsuchida, T., Tokuda, M., Itano, T., Nagao, S., & Hatase, O. (1992). Identification of a src family protein specifically expressed in rat astrocytes by immunohistochemistry and double immunofluorescent study. Brain Research, 585(1-2), 283-286. https://doi.org/10.1016/0006-8993(92)91219-5