Identification of a src family protein specifically expressed in rat astrocytes by immunohistochemistry and double immunofluorescent study

Lizomar J M P Moia, Hideki Matsui, Hajime Nishio, Takahiro Tsuchida, Masaaki Tokuda, Toshifumi Itano, Seigo Nagao, Osamu Hatase

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Identification of a src-related tyrosine kinase and its regional and cellular distributions were studied in rat brain. The study was performed using a specific antibody raised against a synthetic peptide corresponding to the conserved autophosphorylation site of src-family tyrosine kinases. The antibody (α-src antibody) recognized a 43 kDa polypeptide in plasma membrane enriched fraction. The immunohistochemical data revealed that the polypeptide is localized in astrocytes of corpus callosum and fimbria hippocampus. The presence of this src-related protein in astrocytes suggests that it may have some control in their proliferation and differentiation.

Original languageEnglish
Pages (from-to)283-286
Number of pages4
JournalBrain Research
Volume585
Issue number1-2
DOIs
Publication statusPublished - Jul 10 1992
Externally publishedYes

Fingerprint

Astrocytes
src-Family Kinases
Immunohistochemistry
Peptides
Antibodies
Brain Fornix
Proteins
Corpus Callosum
Cell Membrane
Brain

Keywords

  • Astrocyte
  • Corpus callosum
  • Double immunofluorescence study
  • Fimbria hippocampus
  • Glial cell
  • Immunohistochemistry
  • pp60
  • Tyrosine kinase

ASJC Scopus subject areas

  • Developmental Biology
  • Molecular Biology
  • Clinical Neurology
  • Neuroscience(all)

Cite this

Identification of a src family protein specifically expressed in rat astrocytes by immunohistochemistry and double immunofluorescent study. / Moia, Lizomar J M P; Matsui, Hideki; Nishio, Hajime; Tsuchida, Takahiro; Tokuda, Masaaki; Itano, Toshifumi; Nagao, Seigo; Hatase, Osamu.

In: Brain Research, Vol. 585, No. 1-2, 10.07.1992, p. 283-286.

Research output: Contribution to journalArticle

Moia, LJMP, Matsui, H, Nishio, H, Tsuchida, T, Tokuda, M, Itano, T, Nagao, S & Hatase, O 1992, 'Identification of a src family protein specifically expressed in rat astrocytes by immunohistochemistry and double immunofluorescent study', Brain Research, vol. 585, no. 1-2, pp. 283-286. https://doi.org/10.1016/0006-8993(92)91219-5
Moia, Lizomar J M P ; Matsui, Hideki ; Nishio, Hajime ; Tsuchida, Takahiro ; Tokuda, Masaaki ; Itano, Toshifumi ; Nagao, Seigo ; Hatase, Osamu. / Identification of a src family protein specifically expressed in rat astrocytes by immunohistochemistry and double immunofluorescent study. In: Brain Research. 1992 ; Vol. 585, No. 1-2. pp. 283-286.
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