Abstract
Identification of a src-related tyrosine kinase and its regional and cellular distributions were studied in rat brain. The study was performed using a specific antibody raised against a synthetic peptide corresponding to the conserved autophosphorylation site of src-family tyrosine kinases. The antibody (α-src antibody) recognized a 43 kDa polypeptide in plasma membrane enriched fraction. The immunohistochemical data revealed that the polypeptide is localized in astrocytes of corpus callosum and fimbria hippocampus. The presence of this src-related protein in astrocytes suggests that it may have some control in their proliferation and differentiation.
| Original language | English |
|---|---|
| Pages (from-to) | 283-286 |
| Number of pages | 4 |
| Journal | Brain Research |
| Volume | 585 |
| Issue number | 1-2 |
| DOIs | |
| Publication status | Published - Jul 10 1992 |
| Externally published | Yes |
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Keywords
- Astrocyte
- Corpus callosum
- Double immunofluorescence study
- Fimbria hippocampus
- Glial cell
- Immunohistochemistry
- pp60
- Tyrosine kinase
ASJC Scopus subject areas
- Developmental Biology
- Molecular Biology
- Clinical Neurology
- Neuroscience(all)
Cite this
Identification of a src family protein specifically expressed in rat astrocytes by immunohistochemistry and double immunofluorescent study. / Moia, Lizomar J M P; Matsui, Hideki; Nishio, Hajime; Tsuchida, Takahiro; Tokuda, Masaaki; Itano, Toshifumi; Nagao, Seigo; Hatase, Osamu.
In: Brain Research, Vol. 585, No. 1-2, 10.07.1992, p. 283-286.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Identification of a src family protein specifically expressed in rat astrocytes by immunohistochemistry and double immunofluorescent study
AU - Moia, Lizomar J M P
AU - Matsui, Hideki
AU - Nishio, Hajime
AU - Tsuchida, Takahiro
AU - Tokuda, Masaaki
AU - Itano, Toshifumi
AU - Nagao, Seigo
AU - Hatase, Osamu
PY - 1992/7/10
Y1 - 1992/7/10
N2 - Identification of a src-related tyrosine kinase and its regional and cellular distributions were studied in rat brain. The study was performed using a specific antibody raised against a synthetic peptide corresponding to the conserved autophosphorylation site of src-family tyrosine kinases. The antibody (α-src antibody) recognized a 43 kDa polypeptide in plasma membrane enriched fraction. The immunohistochemical data revealed that the polypeptide is localized in astrocytes of corpus callosum and fimbria hippocampus. The presence of this src-related protein in astrocytes suggests that it may have some control in their proliferation and differentiation.
AB - Identification of a src-related tyrosine kinase and its regional and cellular distributions were studied in rat brain. The study was performed using a specific antibody raised against a synthetic peptide corresponding to the conserved autophosphorylation site of src-family tyrosine kinases. The antibody (α-src antibody) recognized a 43 kDa polypeptide in plasma membrane enriched fraction. The immunohistochemical data revealed that the polypeptide is localized in astrocytes of corpus callosum and fimbria hippocampus. The presence of this src-related protein in astrocytes suggests that it may have some control in their proliferation and differentiation.
KW - Astrocyte
KW - Corpus callosum
KW - Double immunofluorescence study
KW - Fimbria hippocampus
KW - Glial cell
KW - Immunohistochemistry
KW - pp60
KW - Tyrosine kinase
UR - http://www.scopus.com/inward/record.url?scp=0026774470&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0026774470&partnerID=8YFLogxK
U2 - 10.1016/0006-8993(92)91219-5
DO - 10.1016/0006-8993(92)91219-5
M3 - Article
C2 - 1380871
AN - SCOPUS:0026774470
VL - 585
SP - 283
EP - 286
JO - Brain Research
JF - Brain Research
SN - 0006-8993
IS - 1-2
ER -