Identification of a novel gene, Mblk-1, that encodes a putative transcription factor expressed preferentially in the large-type Kenyon cells of the honeybee brain

Hideaki Takeuchi, Eriko Kage, Miyuki Sawata, Azusa Kamikouchi, Kazuaki Ohashi, Maya Ohara, Tomoko Fujiyuki, Takekazu Kunieda, Kazuhisa Sekimizu, Shunji Natori, Takeo Kubo

Research output: Contribution to journalArticle

55 Citations (Scopus)

Abstract

Mushroom bodies (MBs) are considered to be involved in higher-order sensory processing in the insect brain. To identify the genes involved in the intrinsic function of the honeybee MBs, we searched for genes preferentially expressed therein, using the differential display method. Here we report a novel gene encoding a putative transcription factor (Mblk-1) expressed preferentially in one of two types of intrinsic MB neurones, the large-type Kenyon cells, which makes Mblk-1 a candidate gene involved in the advanced behaviours of honeybees. A putative DNA binding motif of Mblk-1 had significant sequence homology with those encoded by genes from various animal species, suggesting that the functions of these proteins in neural cells are conserved among the animal kingdom.

Original languageEnglish
Pages (from-to)487-494
Number of pages8
JournalInsect Molecular Biology
Volume10
Issue number5
DOIs
Publication statusPublished - 2001
Externally publishedYes

Fingerprint

honey bees
Mushroom Bodies
Brain
mushroom bodies
Transcription Factors
transcription factors
Genes
brain
Animals
genes
cells
neurons
Gene encoding
Nucleotide Motifs
DNA-binding domains
Neurons
Sequence Homology
sequence homology
Display devices
Insects

Keywords

  • E93
  • Honeybee
  • Mushroom body
  • Social behaviour
  • Transcription factor

ASJC Scopus subject areas

  • Insect Science
  • Biochemistry, Genetics and Molecular Biology(all)
  • Biochemistry

Cite this

Identification of a novel gene, Mblk-1, that encodes a putative transcription factor expressed preferentially in the large-type Kenyon cells of the honeybee brain. / Takeuchi, Hideaki; Kage, Eriko; Sawata, Miyuki; Kamikouchi, Azusa; Ohashi, Kazuaki; Ohara, Maya; Fujiyuki, Tomoko; Kunieda, Takekazu; Sekimizu, Kazuhisa; Natori, Shunji; Kubo, Takeo.

In: Insect Molecular Biology, Vol. 10, No. 5, 2001, p. 487-494.

Research output: Contribution to journalArticle

Takeuchi, Hideaki ; Kage, Eriko ; Sawata, Miyuki ; Kamikouchi, Azusa ; Ohashi, Kazuaki ; Ohara, Maya ; Fujiyuki, Tomoko ; Kunieda, Takekazu ; Sekimizu, Kazuhisa ; Natori, Shunji ; Kubo, Takeo. / Identification of a novel gene, Mblk-1, that encodes a putative transcription factor expressed preferentially in the large-type Kenyon cells of the honeybee brain. In: Insect Molecular Biology. 2001 ; Vol. 10, No. 5. pp. 487-494.
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