Identification and selective perfusion of the spinal cord-feeding arteries by intrathecal pO2 monitoring for spinal cord protection

M. Ishizaki, S. Sugiyama, H. Uchida, S. Nawa, N. Shimizu

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Objectives: to study whether spinal cord-feeding arteries could be identified by the changes in the intrathecal pO2 (I-pO2), and to examine whether selective perfusion of feeding arteries identified by this method could protect the spinal cord against ischaemia. Design: controlled animal experiments. Materials and methods: in experiment 1, using 16 mongrel dogs, 18 segmental arteries were cannulated through which oxygenated saline was injected and the I-pO2 change was observed. When the I-pO2 increase was more than 0.5 mmHg, the artery was considered to be a spinal cord-feeding artery. In experiment 2, involving 10 dogs, the segmental arteries identified as spinal cord-feeding arteries were perfused with arterial blood and the recovery of I-pO2 and evoked spinal potentials (ESP) was examined. Results: of 208 segmental arteries examined, 176 (84.6%) arteries were correctly judged and 32 (15.4%) were not. It was observed that the I-pO2 recovered from 13.9 to 30.5 mmHg and the ESP recovered from 20.9% and 8.2% to 66.5% and 44.7% of each control for the first negative (N1) and second negative (N2) components, respectively. Conclusion: spinal cord-feeding arteries were successfully identified using the I-pO2 monitoring method. Perfusion of these arteries with arterial blood improved the I-pO2 and ESP, which were significantly depressed by ischemia.

Original languageEnglish
Pages (from-to)17-24
Number of pages8
JournalEuropean Journal of Vascular and Endovascular Surgery
Volume18
Issue number1
DOIs
Publication statusPublished - Jul 1999

Keywords

  • Aorta
  • Evoked spinal potentials
  • Feeding artery
  • Intrathecal pO
  • Selective perfusion
  • Spinal ischaemia
  • Surgery

ASJC Scopus subject areas

  • Surgery
  • Cardiology and Cardiovascular Medicine

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