Identification and selective perfusion of the spinal cord-feeding arteries by intrathecal pO2 monitoring for spinal cord protection

M. Ishizaki, S. Sugiyama, Haruhito Adam Uchida, S. Nawa, N. Shimizu

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Objectives: to study whether spinal cord-feeding arteries could be identified by the changes in the intrathecal pO2 (I-pO2), and to examine whether selective perfusion of feeding arteries identified by this method could protect the spinal cord against ischaemia. Design: controlled animal experiments. Materials and methods: in experiment 1, using 16 mongrel dogs, 18 segmental arteries were cannulated through which oxygenated saline was injected and the I-pO2 change was observed. When the I-pO2 increase was more than 0.5 mmHg, the artery was considered to be a spinal cord-feeding artery. In experiment 2, involving 10 dogs, the segmental arteries identified as spinal cord-feeding arteries were perfused with arterial blood and the recovery of I-pO2 and evoked spinal potentials (ESP) was examined. Results: of 208 segmental arteries examined, 176 (84.6%) arteries were correctly judged and 32 (15.4%) were not. It was observed that the I-pO2 recovered from 13.9 to 30.5 mmHg and the ESP recovered from 20.9% and 8.2% to 66.5% and 44.7% of each control for the first negative (N1) and second negative (N2) components, respectively. Conclusion: spinal cord-feeding arteries were successfully identified using the I-pO2 monitoring method. Perfusion of these arteries with arterial blood improved the I-pO2 and ESP, which were significantly depressed by ischemia.

Original languageEnglish
Pages (from-to)17-24
Number of pages8
JournalEuropean Journal of Vascular and Endovascular Surgery
Volume18
Issue number1
DOIs
Publication statusPublished - Jul 1999

Fingerprint

Spinal Cord
Arteries
Perfusion
Evoked Potentials
Dogs
Spinal Cord Ischemia
Ischemia

Keywords

  • Aorta
  • Evoked spinal potentials
  • Feeding artery
  • Intrathecal pO
  • Selective perfusion
  • Spinal ischaemia
  • Surgery

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Radiology Nuclear Medicine and imaging
  • Surgery

Cite this

Identification and selective perfusion of the spinal cord-feeding arteries by intrathecal pO2 monitoring for spinal cord protection. / Ishizaki, M.; Sugiyama, S.; Uchida, Haruhito Adam; Nawa, S.; Shimizu, N.

In: European Journal of Vascular and Endovascular Surgery, Vol. 18, No. 1, 07.1999, p. 17-24.

Research output: Contribution to journalArticle

@article{48125857a7634d49b1258476107ed406,
title = "Identification and selective perfusion of the spinal cord-feeding arteries by intrathecal pO2 monitoring for spinal cord protection",
abstract = "Objectives: to study whether spinal cord-feeding arteries could be identified by the changes in the intrathecal pO2 (I-pO2), and to examine whether selective perfusion of feeding arteries identified by this method could protect the spinal cord against ischaemia. Design: controlled animal experiments. Materials and methods: in experiment 1, using 16 mongrel dogs, 18 segmental arteries were cannulated through which oxygenated saline was injected and the I-pO2 change was observed. When the I-pO2 increase was more than 0.5 mmHg, the artery was considered to be a spinal cord-feeding artery. In experiment 2, involving 10 dogs, the segmental arteries identified as spinal cord-feeding arteries were perfused with arterial blood and the recovery of I-pO2 and evoked spinal potentials (ESP) was examined. Results: of 208 segmental arteries examined, 176 (84.6{\%}) arteries were correctly judged and 32 (15.4{\%}) were not. It was observed that the I-pO2 recovered from 13.9 to 30.5 mmHg and the ESP recovered from 20.9{\%} and 8.2{\%} to 66.5{\%} and 44.7{\%} of each control for the first negative (N1) and second negative (N2) components, respectively. Conclusion: spinal cord-feeding arteries were successfully identified using the I-pO2 monitoring method. Perfusion of these arteries with arterial blood improved the I-pO2 and ESP, which were significantly depressed by ischemia.",
keywords = "Aorta, Evoked spinal potentials, Feeding artery, Intrathecal pO, Selective perfusion, Spinal ischaemia, Surgery",
author = "M. Ishizaki and S. Sugiyama and Uchida, {Haruhito Adam} and S. Nawa and N. Shimizu",
year = "1999",
month = "7",
doi = "10.1053/ejvs.1999.0845",
language = "English",
volume = "18",
pages = "17--24",
journal = "European Journal of Vascular and Endovascular Surgery",
issn = "1078-5884",
publisher = "W.B. Saunders Ltd",
number = "1",

}

TY - JOUR

T1 - Identification and selective perfusion of the spinal cord-feeding arteries by intrathecal pO2 monitoring for spinal cord protection

AU - Ishizaki, M.

AU - Sugiyama, S.

AU - Uchida, Haruhito Adam

AU - Nawa, S.

AU - Shimizu, N.

PY - 1999/7

Y1 - 1999/7

N2 - Objectives: to study whether spinal cord-feeding arteries could be identified by the changes in the intrathecal pO2 (I-pO2), and to examine whether selective perfusion of feeding arteries identified by this method could protect the spinal cord against ischaemia. Design: controlled animal experiments. Materials and methods: in experiment 1, using 16 mongrel dogs, 18 segmental arteries were cannulated through which oxygenated saline was injected and the I-pO2 change was observed. When the I-pO2 increase was more than 0.5 mmHg, the artery was considered to be a spinal cord-feeding artery. In experiment 2, involving 10 dogs, the segmental arteries identified as spinal cord-feeding arteries were perfused with arterial blood and the recovery of I-pO2 and evoked spinal potentials (ESP) was examined. Results: of 208 segmental arteries examined, 176 (84.6%) arteries were correctly judged and 32 (15.4%) were not. It was observed that the I-pO2 recovered from 13.9 to 30.5 mmHg and the ESP recovered from 20.9% and 8.2% to 66.5% and 44.7% of each control for the first negative (N1) and second negative (N2) components, respectively. Conclusion: spinal cord-feeding arteries were successfully identified using the I-pO2 monitoring method. Perfusion of these arteries with arterial blood improved the I-pO2 and ESP, which were significantly depressed by ischemia.

AB - Objectives: to study whether spinal cord-feeding arteries could be identified by the changes in the intrathecal pO2 (I-pO2), and to examine whether selective perfusion of feeding arteries identified by this method could protect the spinal cord against ischaemia. Design: controlled animal experiments. Materials and methods: in experiment 1, using 16 mongrel dogs, 18 segmental arteries were cannulated through which oxygenated saline was injected and the I-pO2 change was observed. When the I-pO2 increase was more than 0.5 mmHg, the artery was considered to be a spinal cord-feeding artery. In experiment 2, involving 10 dogs, the segmental arteries identified as spinal cord-feeding arteries were perfused with arterial blood and the recovery of I-pO2 and evoked spinal potentials (ESP) was examined. Results: of 208 segmental arteries examined, 176 (84.6%) arteries were correctly judged and 32 (15.4%) were not. It was observed that the I-pO2 recovered from 13.9 to 30.5 mmHg and the ESP recovered from 20.9% and 8.2% to 66.5% and 44.7% of each control for the first negative (N1) and second negative (N2) components, respectively. Conclusion: spinal cord-feeding arteries were successfully identified using the I-pO2 monitoring method. Perfusion of these arteries with arterial blood improved the I-pO2 and ESP, which were significantly depressed by ischemia.

KW - Aorta

KW - Evoked spinal potentials

KW - Feeding artery

KW - Intrathecal pO

KW - Selective perfusion

KW - Spinal ischaemia

KW - Surgery

UR - http://www.scopus.com/inward/record.url?scp=0033166799&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0033166799&partnerID=8YFLogxK

U2 - 10.1053/ejvs.1999.0845

DO - 10.1053/ejvs.1999.0845

M3 - Article

C2 - 10388634

AN - SCOPUS:0033166799

VL - 18

SP - 17

EP - 24

JO - European Journal of Vascular and Endovascular Surgery

JF - European Journal of Vascular and Endovascular Surgery

SN - 1078-5884

IS - 1

ER -