Identification and characterization of Mlr1,2: Two mouse homologues of Mblk-1, a transcription factor from the honeybee brain

Takekazu Kunieda, Jung Min Park, Hideaki Takeuchi, Takeo Kubo, Takashi Gojobori

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

We previously identified the Mblk-1 gene in the honeybee brain, which encodes a transcription factor containing two DNA binding motifs, termed RHF1 and 2 (Takeuchi et al. (2001) Insect Mol. Biol. 121, 134-140). Here, we identified two mouse Mblk1 homologues, Mlr1 and Mlr2. Both encode proteins containing a single DNA-binding motif highly conserved with RHF2 and activate transcription mediated by a DNA element recognized by honeybee Mblk-1. Mlr1 was expressed predominantly in the spermatocytes of the testis, while Mlr2 was expressed in various tissues other than testis. Mlr1 transcripts were lost in the testis of W/Wv mutant mice, suggesting a role in spermatogenesis.

Original languageEnglish
Pages (from-to)61-65
Number of pages5
JournalFEBS Letters
Volume535
Issue number1-3
DOIs
Publication statusPublished - Jan 30 2003
Externally publishedYes

Keywords

  • Brain
  • E93
  • Honeybee
  • Spermatocytes
  • Spermatogenesis
  • Transcription factor

ASJC Scopus subject areas

  • Biophysics
  • Structural Biology
  • Biochemistry
  • Molecular Biology
  • Genetics
  • Cell Biology

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