Identification and characterization of mammalian 5-formyluracil-DNA glycosylase.

Mayumi Matsubara, Aya Masaoka, Tamon Tanaka, Hiroaki Terato, Yoshihiko Ohyama, Hiroshi Ide

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

5-Formyluracil is a major oxidative thymine lesion with mutagenic and cytotoxic properties. In this study, we have partially purified and characterized a mammalian 5-formyluracil-DNA glycosylase (FDG) from rat liver. FDG was a monofunctional DNA glycosylase and removed 5-formyluracil, uracil, 5-hydroxyuracil, 5-hydroxylmethyluracil in single-stranded and double-stranded DNA. Several lines of evidence indicate that FDG is a rat SMUG1 homologue. Human SMUG1 also exhibited similar enzymatic properties.

Original languageEnglish
Pages (from-to)233-234
Number of pages2
JournalNucleic acids research. Supplement (2001)
Issue number3
Publication statusPublished - 2003
Externally publishedYes

    Fingerprint

ASJC Scopus subject areas

  • Medicine(all)

Cite this