Identification and Characterization of Heat-Stable Enterotoxin ll-Producing Escherichia coli from Patients with Diarrhea

Keinosuke Okamoto; Noriko Akashi; Shunji Hitotsubashi; Yoshio Fujii; Yoshifumi Takeda; Tadahiro Karasawa; Hisao Kurazono

Identification and Characterization of Heat-Stable Enterotoxin ll-Producing Escherichia coli from Patients with Diarrhea

Keinosuke Okamoto, Noriko Akashi, Shunji Hitotsubashi, Yoshio Fujii, Yoshifumi Takeda, Tadahiro Karasawa, Hisao Kurazono

Research output: Contribution to journal › Article › peer-review

Abstract

Stock strains of Eschericia coli isolated from patients with traveller's diarrhea were examined for production of heat-stable enterotoxin II (STII). of 400 strains examined, 3 were found to produce STII. The nucleotide sequence of the STII gene of these human strains was shown to be identical to that of porcine strains. Cultured cells of these strains induced fluid accumulation in ligated mouse intestinal loops and the activity was neutralized by anti-STII antiserum. These results suggest that STII-produciing enterotoxigenic E. coli can cause human diarrhea.

Original language	English
Pages (from-to)	774-777
Number of pages	4
Journal	Microbiology and Immunology
Volume	37
Issue number	5
Publication status	Published - 1993
Externally published	Yes

Keywords

Diarrhea
Escherichia coli
Heat-stable enterotoxin

ASJC Scopus subject areas

Microbiology
Immunology
Virology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Cite this

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title = "Identification and Characterization of Heat-Stable Enterotoxin ll-Producing Escherichia coli from Patients with Diarrhea",

abstract = "Stock strains of Eschericia coli isolated from patients with traveller's diarrhea were examined for production of heat-stable enterotoxin II (STII). of 400 strains examined, 3 were found to produce STII. The nucleotide sequence of the STII gene of these human strains was shown to be identical to that of porcine strains. Cultured cells of these strains induced fluid accumulation in ligated mouse intestinal loops and the activity was neutralized by anti-STII antiserum. These results suggest that STII-produciing enterotoxigenic E. coli can cause human diarrhea.",

keywords = "Diarrhea, Escherichia coli, Heat-stable enterotoxin",

author = "Keinosuke Okamoto and Noriko Akashi and Shunji Hitotsubashi and Yoshio Fujii and Yoshifumi Takeda and Tadahiro Karasawa and Hisao Kurazono",

year = "1993",

language = "English",

volume = "37",

pages = "774--777",

journal = "Microbiology and Immunology",

issn = "0385-5600",

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TY - JOUR

T1 - Identification and Characterization of Heat-Stable Enterotoxin ll-Producing Escherichia coli from Patients with Diarrhea

AU - Okamoto, Keinosuke

AU - Akashi, Noriko

AU - Hitotsubashi, Shunji

AU - Fujii, Yoshio

AU - Takeda, Yoshifumi

AU - Karasawa, Tadahiro

AU - Kurazono, Hisao

PY - 1993

Y1 - 1993

N2 - Stock strains of Eschericia coli isolated from patients with traveller's diarrhea were examined for production of heat-stable enterotoxin II (STII). of 400 strains examined, 3 were found to produce STII. The nucleotide sequence of the STII gene of these human strains was shown to be identical to that of porcine strains. Cultured cells of these strains induced fluid accumulation in ligated mouse intestinal loops and the activity was neutralized by anti-STII antiserum. These results suggest that STII-produciing enterotoxigenic E. coli can cause human diarrhea.

AB - Stock strains of Eschericia coli isolated from patients with traveller's diarrhea were examined for production of heat-stable enterotoxin II (STII). of 400 strains examined, 3 were found to produce STII. The nucleotide sequence of the STII gene of these human strains was shown to be identical to that of porcine strains. Cultured cells of these strains induced fluid accumulation in ligated mouse intestinal loops and the activity was neutralized by anti-STII antiserum. These results suggest that STII-produciing enterotoxigenic E. coli can cause human diarrhea.

KW - Diarrhea

KW - Escherichia coli

KW - Heat-stable enterotoxin

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M3 - Article

AN - SCOPUS:85024274881

SN - 0385-5600

VL - 37

SP - 774

EP - 777

JO - Microbiology and Immunology

JF - Microbiology and Immunology

IS - 5

ER -

Identification and Characterization of Heat-Stable Enterotoxin ll-Producing Escherichia coli from Patients with Diarrhea

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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