Identification and Characterization of Heat-Stable Enterotoxin ll-Producing Escherichia coli from Patients with Diarrhea

Keinosuke Okamoto, Noriko Akashi, Shunji Hitotsubashi, Yoshio Fujii, Yoshifumi Takeda, Tadahiro Karasawa, Hisao Kurazono

Research output: Contribution to journalArticle

Abstract

Stock strains of Eschericia coli isolated from patients with traveller's diarrhea were examined for production of heat-stable enterotoxin II (STII). of 400 strains examined, 3 were found to produce STII. The nucleotide sequence of the STII gene of these human strains was shown to be identical to that of porcine strains. Cultured cells of these strains induced fluid accumulation in ligated mouse intestinal loops and the activity was neutralized by anti-STII antiserum. These results suggest that STII-produciing enterotoxigenic E. coli can cause human diarrhea.

Original languageEnglish
Pages (from-to)774-777
Number of pages4
JournalMicrobiology and Immunology
Volume37
Issue number5
Publication statusPublished - 1993
Externally publishedYes

Keywords

  • Diarrhea
  • Escherichia coli
  • Heat-stable enterotoxin

ASJC Scopus subject areas

  • Microbiology
  • Immunology
  • Virology

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    Okamoto, K., Akashi, N., Hitotsubashi, S., Fujii, Y., Takeda, Y., Karasawa, T., & Kurazono, H. (1993). Identification and Characterization of Heat-Stable Enterotoxin ll-Producing Escherichia coli from Patients with Diarrhea. Microbiology and Immunology, 37(5), 774-777.