Ichthyosiform eruptions in association with primary cutaneous T-cell lymphomas

Shin Morizane, N. Setsu, T. Yamamoto, T. Hamada, G. Nakanishi, K. Asagoe, K. Iwatsuki

Research output: Contribution to journalArticle

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Abstract

Background Malignant lymphoma is occasionally complicated by ichthyosiform eruptions. Objectives To analyse histopathologically the ichthyosiform eruptions associated with cutaneous lymphomas. Methods We reviewed the files of patients with malignant lymphoma seen in our dermatology department between January 2001 and May 2006 to search for patients with ichthyosiform eruptions. Results In our series, nine of 106 patients with malignant lymphomas had ichthyosiform eruptions during their clinical courses, including three (30%) of 10 patients with anaplastic large cell lymphoma (ALCL) and six (14%) of 44 patients with mycosis fungoides (MF). None of the 18 patients with cutaneous B-cell lymphoma had ichthyosiform eruptions. The three patients with ALCL had ichthyosiform eruptions histopathologically consistent with acquired ichthyosis (AI) in which packed horny layers and thin granular layers were present without lymphocytic infiltration. In contrast, four of the six patients with MF (stages Ib and IIb) had ichthyosiform eruptions with epidermotropic infiltration of atypical lymphocytes, as observed in ichthyosiform MF (IMF). Of the remaining two patients, one showed histopathological features overlapping AI and IMF, and the other had AI alone. These two patients (stages IVa and IIb) had tumours composed of CD30+ cells. Filaggrin expression was markedly diminished in both AI and IMF-like eruptions, similar to that of inherited ichthyosis vulgaris. Conclusions Ichthyosiform eruptions are often associated with ALCL and MF and can be classified into three groups: AI associated with ALCL and MF expressing CD30, IMF, and their overlap.

Original languageEnglish
Pages (from-to)115-120
Number of pages6
JournalBritish Journal of Dermatology
Volume161
Issue number1
DOIs
Publication statusPublished - Jul 2009

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Cutaneous T-Cell Lymphoma
Mycosis Fungoides
Anaplastic Large-Cell Lymphoma
Lymphoma
Ichthyosis Vulgaris
Skin
B-Cell Lymphoma
Dermatology
Acquired ichthyosis
Lymphocytes

Keywords

  • Acquired ichthyosis
  • Anaplastic large cell lymphoma
  • Ichthyosiform mycosis fungoides

ASJC Scopus subject areas

  • Dermatology

Cite this

Ichthyosiform eruptions in association with primary cutaneous T-cell lymphomas. / Morizane, Shin; Setsu, N.; Yamamoto, T.; Hamada, T.; Nakanishi, G.; Asagoe, K.; Iwatsuki, K.

In: British Journal of Dermatology, Vol. 161, No. 1, 07.2009, p. 115-120.

Research output: Contribution to journalArticle

Morizane, S, Setsu, N, Yamamoto, T, Hamada, T, Nakanishi, G, Asagoe, K & Iwatsuki, K 2009, 'Ichthyosiform eruptions in association with primary cutaneous T-cell lymphomas', British Journal of Dermatology, vol. 161, no. 1, pp. 115-120. https://doi.org/10.1111/j.1365-2133.2009.09109.x
Morizane, Shin ; Setsu, N. ; Yamamoto, T. ; Hamada, T. ; Nakanishi, G. ; Asagoe, K. ; Iwatsuki, K. / Ichthyosiform eruptions in association with primary cutaneous T-cell lymphomas. In: British Journal of Dermatology. 2009 ; Vol. 161, No. 1. pp. 115-120.
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abstract = "Background Malignant lymphoma is occasionally complicated by ichthyosiform eruptions. Objectives To analyse histopathologically the ichthyosiform eruptions associated with cutaneous lymphomas. Methods We reviewed the files of patients with malignant lymphoma seen in our dermatology department between January 2001 and May 2006 to search for patients with ichthyosiform eruptions. Results In our series, nine of 106 patients with malignant lymphomas had ichthyosiform eruptions during their clinical courses, including three (30{\%}) of 10 patients with anaplastic large cell lymphoma (ALCL) and six (14{\%}) of 44 patients with mycosis fungoides (MF). None of the 18 patients with cutaneous B-cell lymphoma had ichthyosiform eruptions. The three patients with ALCL had ichthyosiform eruptions histopathologically consistent with acquired ichthyosis (AI) in which packed horny layers and thin granular layers were present without lymphocytic infiltration. In contrast, four of the six patients with MF (stages Ib and IIb) had ichthyosiform eruptions with epidermotropic infiltration of atypical lymphocytes, as observed in ichthyosiform MF (IMF). Of the remaining two patients, one showed histopathological features overlapping AI and IMF, and the other had AI alone. These two patients (stages IVa and IIb) had tumours composed of CD30+ cells. Filaggrin expression was markedly diminished in both AI and IMF-like eruptions, similar to that of inherited ichthyosis vulgaris. Conclusions Ichthyosiform eruptions are often associated with ALCL and MF and can be classified into three groups: AI associated with ALCL and MF expressing CD30, IMF, and their overlap.",
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AU - Morizane, Shin

AU - Setsu, N.

AU - Yamamoto, T.

AU - Hamada, T.

AU - Nakanishi, G.

AU - Asagoe, K.

AU - Iwatsuki, K.

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N2 - Background Malignant lymphoma is occasionally complicated by ichthyosiform eruptions. Objectives To analyse histopathologically the ichthyosiform eruptions associated with cutaneous lymphomas. Methods We reviewed the files of patients with malignant lymphoma seen in our dermatology department between January 2001 and May 2006 to search for patients with ichthyosiform eruptions. Results In our series, nine of 106 patients with malignant lymphomas had ichthyosiform eruptions during their clinical courses, including three (30%) of 10 patients with anaplastic large cell lymphoma (ALCL) and six (14%) of 44 patients with mycosis fungoides (MF). None of the 18 patients with cutaneous B-cell lymphoma had ichthyosiform eruptions. The three patients with ALCL had ichthyosiform eruptions histopathologically consistent with acquired ichthyosis (AI) in which packed horny layers and thin granular layers were present without lymphocytic infiltration. In contrast, four of the six patients with MF (stages Ib and IIb) had ichthyosiform eruptions with epidermotropic infiltration of atypical lymphocytes, as observed in ichthyosiform MF (IMF). Of the remaining two patients, one showed histopathological features overlapping AI and IMF, and the other had AI alone. These two patients (stages IVa and IIb) had tumours composed of CD30+ cells. Filaggrin expression was markedly diminished in both AI and IMF-like eruptions, similar to that of inherited ichthyosis vulgaris. Conclusions Ichthyosiform eruptions are often associated with ALCL and MF and can be classified into three groups: AI associated with ALCL and MF expressing CD30, IMF, and their overlap.

AB - Background Malignant lymphoma is occasionally complicated by ichthyosiform eruptions. Objectives To analyse histopathologically the ichthyosiform eruptions associated with cutaneous lymphomas. Methods We reviewed the files of patients with malignant lymphoma seen in our dermatology department between January 2001 and May 2006 to search for patients with ichthyosiform eruptions. Results In our series, nine of 106 patients with malignant lymphomas had ichthyosiform eruptions during their clinical courses, including three (30%) of 10 patients with anaplastic large cell lymphoma (ALCL) and six (14%) of 44 patients with mycosis fungoides (MF). None of the 18 patients with cutaneous B-cell lymphoma had ichthyosiform eruptions. The three patients with ALCL had ichthyosiform eruptions histopathologically consistent with acquired ichthyosis (AI) in which packed horny layers and thin granular layers were present without lymphocytic infiltration. In contrast, four of the six patients with MF (stages Ib and IIb) had ichthyosiform eruptions with epidermotropic infiltration of atypical lymphocytes, as observed in ichthyosiform MF (IMF). Of the remaining two patients, one showed histopathological features overlapping AI and IMF, and the other had AI alone. These two patients (stages IVa and IIb) had tumours composed of CD30+ cells. Filaggrin expression was markedly diminished in both AI and IMF-like eruptions, similar to that of inherited ichthyosis vulgaris. Conclusions Ichthyosiform eruptions are often associated with ALCL and MF and can be classified into three groups: AI associated with ALCL and MF expressing CD30, IMF, and their overlap.

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KW - Ichthyosiform mycosis fungoides

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