Hyrtioseragamines A and B, new alkaloids from the sponge hyrtios species

Yohei Takahashi, Yoshiro Iinuma, Takaaki Kubota, Masashi Tsuda, Mitsuhiro Sekiguchi, Yuzuru Mikami, Jane Fromont, Jun'Ichi Kobayashi

Research output: Contribution to journalArticlepeer-review

29 Citations (Scopus)


Two novel alkaloids with a furo[2,3-b]pyrazin-2(1H)-one moiety and a guanidino group, hyrtioseragamines A (1) and B (2), have been isolated from an Okinawan marine sponge Hyrtios species. The structures of 1 and 2 were elucidated on the basis of spectroscopic data and chemical conversions. Compounds 1 and 2 are the first natural products possessing a furo[2,3-b]pyrazine-related moiety.

Original languageEnglish
Pages (from-to)628-631
Number of pages4
JournalOrganic Letters
Issue number4
Publication statusPublished - Feb 18 2011
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry


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