Hyrtioseragamines A and B, new alkaloids from the sponge hyrtios species

Yohei Takahashi; Yoshiro Iinuma; Takaaki Kubota; Masashi Tsuda; Mitsuhiro Sekiguchi; Yuzuru Mikami; Jane Fromont; Jun'Ichi Kobayashi

doi:10.1021/ol102867x

Hyrtioseragamines A and B, new alkaloids from the sponge hyrtios species

Yohei Takahashi, Yoshiro Iinuma, Takaaki Kubota, Masashi Tsuda, Mitsuhiro Sekiguchi, Yuzuru Mikami, Jane Fromont, Jun'Ichi Kobayashi

Research output: Contribution to journal › Article › peer-review

28 Citations (Scopus)

Abstract

Two novel alkaloids with a furo[2,3-b]pyrazin-2(1H)-one moiety and a guanidino group, hyrtioseragamines A (1) and B (2), have been isolated from an Okinawan marine sponge Hyrtios species. The structures of 1 and 2 were elucidated on the basis of spectroscopic data and chemical conversions. Compounds 1 and 2 are the first natural products possessing a furo[2,3-b]pyrazine-related moiety.

Original language	English
Pages (from-to)	628-631
Number of pages	4
Journal	Organic Letters
Volume	13
Issue number	4
DOIs	https://doi.org/10.1021/ol102867x
Publication status	Published - Feb 18 2011
Externally published	Yes

ASJC Scopus subject areas

Biochemistry
Physical and Theoretical Chemistry
Organic Chemistry

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10.1021/ol102867x

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abstract = "Two novel alkaloids with a furo[2,3-b]pyrazin-2(1H)-one moiety and a guanidino group, hyrtioseragamines A (1) and B (2), have been isolated from an Okinawan marine sponge Hyrtios species. The structures of 1 and 2 were elucidated on the basis of spectroscopic data and chemical conversions. Compounds 1 and 2 are the first natural products possessing a furo[2,3-b]pyrazine-related moiety.",

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AU - Takahashi, Yohei

AU - Iinuma, Yoshiro

AU - Kubota, Takaaki

AU - Tsuda, Masashi

AU - Sekiguchi, Mitsuhiro

AU - Mikami, Yuzuru

AU - Fromont, Jane

AU - Kobayashi, Jun'Ichi

PY - 2011/2/18

Y1 - 2011/2/18

N2 - Two novel alkaloids with a furo[2,3-b]pyrazin-2(1H)-one moiety and a guanidino group, hyrtioseragamines A (1) and B (2), have been isolated from an Okinawan marine sponge Hyrtios species. The structures of 1 and 2 were elucidated on the basis of spectroscopic data and chemical conversions. Compounds 1 and 2 are the first natural products possessing a furo[2,3-b]pyrazine-related moiety.

AB - Two novel alkaloids with a furo[2,3-b]pyrazin-2(1H)-one moiety and a guanidino group, hyrtioseragamines A (1) and B (2), have been isolated from an Okinawan marine sponge Hyrtios species. The structures of 1 and 2 were elucidated on the basis of spectroscopic data and chemical conversions. Compounds 1 and 2 are the first natural products possessing a furo[2,3-b]pyrazine-related moiety.

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JF - Organic Letters

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Hyrtioseragamines A and B, new alkaloids from the sponge hyrtios species

Abstract

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