Hyrtinadines C and D, new azepinoindole-type alkaloids from a marine sponge Hyrtios sp.

Takaaki Kubota, Kenta Nakamura, Kanae Sakai, Jane Fromont, Tohru Gonoi, Jun'ichi Kobayashi

Research output: Contribution to journalArticlepeer-review

12 Citations (Scopus)

Abstract

New bisindole alkaloids, hyrtinadines C (1) and D (2), have been isolated from an Okinawan marine sponge Hyrtios sp. The structures of hyrtinadines C (1) and D (2) were elucidated based on analyses of the spectral data. Hyrtinadines C (1) and D (2) were the relatively rare alkaloids possessing a 3,4-fused azepinoindole skeleton. Hyrtinadines C (1) and D (2) showed antimicrobial activity.

Original languageEnglish
Pages (from-to)975-978
Number of pages4
JournalChemical and Pharmaceutical Bulletin
Volume64
Issue number7
DOIs
Publication statusPublished - 2016
Externally publishedYes

Keywords

  • Antimicrobial activity
  • Azepinoindole
  • Bisindole
  • Hyrtinadine
  • Hyrtios sp.
  • Marine sponge

ASJC Scopus subject areas

  • Chemistry(all)
  • Drug Discovery

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