Hyrtimomines D and E, bisindole alkaloids from a marine sponge Hyrtios sp.

Naonobu Tanaka; Rei Momose; Yohei Takahashi; Takaaki Kubota; Azusa Takahashi-Nakaguchi; Tohru Gonoi; Jane Fromont; Jun'Ichi Kobayashi

doi:10.1016/j.tetlet.2013.05.073

Hyrtimomines D and E, bisindole alkaloids from a marine sponge Hyrtios sp.

Naonobu Tanaka, Rei Momose, Yohei Takahashi, Takaaki Kubota, Azusa Takahashi-Nakaguchi, Tohru Gonoi, Jane Fromont, Jun'Ichi Kobayashi

Research output: Contribution to journal › Article › peer-review

27 Citations (Scopus)

Abstract

Two new alkaloids, hyrtimomines D (1) and E (2), were isolated from an Okinawan marine sponge Hyrtios sp. The structures of 1 and 2 were elucidated on the basis of spectroscopic analysis. Hyrtimomines D (1) and E (2) are structurally unique bisindole alkaloids possessing the canthin-6-one skeleton with a hydroxyindole and an imidazolium units. Hyrtimomines D (1) and E (2) exhibited antimicrobial activity.

Original language	English
Pages (from-to)	4038-4040
Number of pages	3
Journal	Tetrahedron Letters
Volume	54
Issue number	31
DOIs	https://doi.org/10.1016/j.tetlet.2013.05.073
Publication status	Published - Jul 31 2013
Externally published	Yes

Keywords

Bisindole alkaloids
Hyrtimomines D and E
Hyrtios sp.
Marine sponge

ASJC Scopus subject areas

Biochemistry
Drug Discovery
Organic Chemistry

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1016/j.tetlet.2013.05.073

Cite this

@article{14816fd9488b4d47aeb8daa7f45ec3d7,

title = "Hyrtimomines D and E, bisindole alkaloids from a marine sponge Hyrtios sp.",

abstract = "Two new alkaloids, hyrtimomines D (1) and E (2), were isolated from an Okinawan marine sponge Hyrtios sp. The structures of 1 and 2 were elucidated on the basis of spectroscopic analysis. Hyrtimomines D (1) and E (2) are structurally unique bisindole alkaloids possessing the canthin-6-one skeleton with a hydroxyindole and an imidazolium units. Hyrtimomines D (1) and E (2) exhibited antimicrobial activity.",

keywords = "Bisindole alkaloids, Hyrtimomines D and E, Hyrtios sp., Marine sponge",

author = "Naonobu Tanaka and Rei Momose and Yohei Takahashi and Takaaki Kubota and Azusa Takahashi-Nakaguchi and Tohru Gonoi and Jane Fromont and Jun'Ichi Kobayashi",

note = "Funding Information: We thank S. Oka and A. Tokumitsu, Equipment Management Center, Hokkaido University, for measurements of MS spectra, and Z. Nagahama for help with sponge collection. This work was partly supported by a Grant-in-Aid for Scientific Research from the Ministry of Education, Culture, Sports, Science and Technology of Japan. ",

year = "2013",

month = jul,

day = "31",

doi = "10.1016/j.tetlet.2013.05.073",

language = "English",

volume = "54",

pages = "4038--4040",

journal = "Tetrahedron Letters",

issn = "0040-4039",

publisher = "Elsevier Limited",

number = "31",

}

TY - JOUR

T1 - Hyrtimomines D and E, bisindole alkaloids from a marine sponge Hyrtios sp.

AU - Tanaka, Naonobu

AU - Momose, Rei

AU - Takahashi, Yohei

AU - Kubota, Takaaki

AU - Takahashi-Nakaguchi, Azusa

AU - Gonoi, Tohru

AU - Fromont, Jane

AU - Kobayashi, Jun'Ichi

N1 - Funding Information: We thank S. Oka and A. Tokumitsu, Equipment Management Center, Hokkaido University, for measurements of MS spectra, and Z. Nagahama for help with sponge collection. This work was partly supported by a Grant-in-Aid for Scientific Research from the Ministry of Education, Culture, Sports, Science and Technology of Japan.

PY - 2013/7/31

Y1 - 2013/7/31

N2 - Two new alkaloids, hyrtimomines D (1) and E (2), were isolated from an Okinawan marine sponge Hyrtios sp. The structures of 1 and 2 were elucidated on the basis of spectroscopic analysis. Hyrtimomines D (1) and E (2) are structurally unique bisindole alkaloids possessing the canthin-6-one skeleton with a hydroxyindole and an imidazolium units. Hyrtimomines D (1) and E (2) exhibited antimicrobial activity.

AB - Two new alkaloids, hyrtimomines D (1) and E (2), were isolated from an Okinawan marine sponge Hyrtios sp. The structures of 1 and 2 were elucidated on the basis of spectroscopic analysis. Hyrtimomines D (1) and E (2) are structurally unique bisindole alkaloids possessing the canthin-6-one skeleton with a hydroxyindole and an imidazolium units. Hyrtimomines D (1) and E (2) exhibited antimicrobial activity.

KW - Bisindole alkaloids

KW - Hyrtimomines D and E

KW - Hyrtios sp.

KW - Marine sponge

UR - http://www.scopus.com/inward/record.url?scp=84879689561&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84879689561&partnerID=8YFLogxK

U2 - 10.1016/j.tetlet.2013.05.073

DO - 10.1016/j.tetlet.2013.05.073

M3 - Article

AN - SCOPUS:84879689561

VL - 54

SP - 4038

EP - 4040

JO - Tetrahedron Letters

JF - Tetrahedron Letters

SN - 0040-4039

IS - 31

ER -

Hyrtimomines D and E, bisindole alkaloids from a marine sponge Hyrtios sp.

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this