Hyrtimomines D and E, bisindole alkaloids from a marine sponge Hyrtios sp.

Naonobu Tanaka, Rei Momose, Yohei Takahashi, Takaaki Kubota, Azusa Takahashi-Nakaguchi, Tohru Gonoi, Jane Fromont, Jun'Ichi Kobayashi

Research output: Contribution to journalArticlepeer-review

27 Citations (Scopus)


Two new alkaloids, hyrtimomines D (1) and E (2), were isolated from an Okinawan marine sponge Hyrtios sp. The structures of 1 and 2 were elucidated on the basis of spectroscopic analysis. Hyrtimomines D (1) and E (2) are structurally unique bisindole alkaloids possessing the canthin-6-one skeleton with a hydroxyindole and an imidazolium units. Hyrtimomines D (1) and E (2) exhibited antimicrobial activity.

Original languageEnglish
Pages (from-to)4038-4040
Number of pages3
JournalTetrahedron Letters
Issue number31
Publication statusPublished - Jul 31 2013
Externally publishedYes


  • Bisindole alkaloids
  • Hyrtimomines D and E
  • Hyrtios sp.
  • Marine sponge

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry


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