Hypoxic induction of vascular endothelial growth factor is impaired in the spinal cord of the mice with mutant human SOD1 gene

Isao Nagano, Tetsuro Murakami, Mito Shiote, Hristelina Ilieva, Yasuhiro Manabe, Mikio Shoji, Koji Abe

Research output: Contribution to journalArticle

Abstract

We examined the induction of vascular endothelial growth factor (VEGF) in the G93A superoxide dismutase (SOD)1-mutant mice exposed to systemic hypoxia. Generally, baseline expression of VEGF in the spinal cord was increased in the SOD1-mutant mice compared with wild-type littermates. VEGF expression in the mutant mice was hardly induced by hypoxia, in contrast to the wild-type littermates where approximately 9-fold increase in VEGF expression was observed, indicating that the response of VEGF to hypoxia is impaired in the SOD1-mutant mice. Our results suggest that the impaired response to hypoxia might be part of precipitating factors for motor neuron death in the SOD1-mutant mice.

Original languageEnglish
Pages (from-to)57-63
Number of pages7
JournalInternational Congress Series
Volume1252
Issue numberC
DOIs
Publication statusPublished - Jun 1 2003

Keywords

  • Amyotrophic lateral sclerosis
  • Hypoxia
  • Motor neuron
  • Superoxide dismutase 1
  • Vascular endothelial growth factor

ASJC Scopus subject areas

  • Medicine(all)

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