We examined the induction of vascular endothelial growth factor (VEGF) in the G93A superoxide dismutase (SOD)1-mutant mice exposed to systemic hypoxia. Generally, baseline expression of VEGF in the spinal cord was increased in the SOD1-mutant mice compared with wild-type littermates. VEGF expression in the mutant mice was hardly induced by hypoxia, in contrast to the wild-type littermates where approximately 9-fold increase in VEGF expression was observed, indicating that the response of VEGF to hypoxia is impaired in the SOD1-mutant mice. Our results suggest that the impaired response to hypoxia might be part of precipitating factors for motor neuron death in the SOD1-mutant mice.
- Amyotrophic lateral sclerosis
- Motor neuron
- Superoxide dismutase 1
- Vascular endothelial growth factor
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