TY - JOUR
T1 - Hypothesis
T2 - The antitumor activities of statins may be mediated by IL-18
AU - Takahashi, Hideo Kohka
AU - Weitz-Schmidt, Gabriele
AU - Iwagaki, Hiromi
AU - Yoshino, Tadashi
AU - Tanaka, Noriaki
AU - Nishibori, Masahiro
PY - 2006/8
Y1 - 2006/8
N2 - Statins, which inhibit 3-hydroxy-3-methylglutaryl coenzyme-A (HMG-CoA) reductase, are thought to reduce the risk of cancer through the inhibition of Ras farnesylation and serum lipid level. A pleiotropic proinflammatory cytokine, interleukin-18 (IL-18), is reported to exhibit significant antitumor activities through the activation of cytotoxic T lymphocytes and natural killer cells and the inhibition of angiogenesis. Previously, we found that pravastatin, fluvastatin, and simvastatin induced the production of IL-18 in human monocytes. The addition of mevalonate abolished the IL-18 production induced by pravastatin, fluvastatin, and simvastatin, indicating that the IL-18 production might be a result of the inhibition of HMG-CoA reductase. We present a new hypothesis that the production of IL-18 might play roles in the action of statins on cancer.
AB - Statins, which inhibit 3-hydroxy-3-methylglutaryl coenzyme-A (HMG-CoA) reductase, are thought to reduce the risk of cancer through the inhibition of Ras farnesylation and serum lipid level. A pleiotropic proinflammatory cytokine, interleukin-18 (IL-18), is reported to exhibit significant antitumor activities through the activation of cytotoxic T lymphocytes and natural killer cells and the inhibition of angiogenesis. Previously, we found that pravastatin, fluvastatin, and simvastatin induced the production of IL-18 in human monocytes. The addition of mevalonate abolished the IL-18 production induced by pravastatin, fluvastatin, and simvastatin, indicating that the IL-18 production might be a result of the inhibition of HMG-CoA reductase. We present a new hypothesis that the production of IL-18 might play roles in the action of statins on cancer.
KW - Cancer
KW - Statin
UR - http://www.scopus.com/inward/record.url?scp=33748852247&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=33748852247&partnerID=8YFLogxK
U2 - 10.1189/jlb.0406245
DO - 10.1189/jlb.0406245
M3 - Article
C2 - 16735695
AN - SCOPUS:33748852247
SN - 0741-5400
VL - 80
SP - 215
EP - 216
JO - Journal of Leukocyte Biology
JF - Journal of Leukocyte Biology
IS - 2
ER -
