Hyponatremia and in-hospital mortality in patients admitted for heart failure (from the ATTEND Registry)

Naoki Sato, Mihai Gheorghiade, Katsuya Kajimoto, Ryo Munakata, Yuichiro Minami, Masayuki Mizuno, Toshiyuki Aokage, Kuniya Asai, Yasushi Sakata, Dai Yumino, Kyoichi Mizuno, Teruo Takano

Research output: Contribution to journalArticle

42 Citations (Scopus)

Abstract

Hyponatremia is known to be a poor prognostic factor in patients hospitalized with heart failure (HF), however not well studied in Japan. The aims of this study were to characterize hyponatremic hospitalized patients with HF and to clarify the relations between hyponatremia and detailed in-hospital outcomes in Japan. Among 4,837 hospitalized patients with HF enrolled in the Acute Decompensated Heart Failure Syndromes (ATTEND) registry, patient characteristics and in-hospital mortality in those with hyponatremia were examined. Hyponatremia (sodium <135 mEq/L) was observed in 11.6% of patients. Patients with hyponatremia were of similar age, included fewer men, and had a higher proportion of previous hospitalizations for HF compared to those with normonatremia. On admission, lower heart rates and blood pressures and higher brain natriuretic peptide levels were observed in patients with hyponatremia. During hospitalization, inotrope levels and mechanical device use were significantly higher in patients with hyponatremia. Rates of all-cause and cardiac death were significantly higher in patients with hyponatremia, 15.0% and 11.4%, respectively, compared to 5.3% and 3.6%, respectively, in those with normonatremia. In hyponatremic hospitalized patients with HF, cardiac death accounted for 76.2% of all-cause death. In conclusion, the present study demonstrates that in Japan hyponatremia in patients hospitalized with HF is relatively common and is associated with a very high in-hospital mortality.

Original languageEnglish
Pages (from-to)1019-1025
Number of pages7
JournalAmerican Journal of Cardiology
Volume111
Issue number7
DOIs
Publication statusPublished - Apr 1 2013
Externally publishedYes

Fingerprint

Hyponatremia
Hospital Mortality
Registries
Heart Failure
Japan
Cause of Death
Hospitalization
Brain Natriuretic Peptide
Heart Rate
Sodium
Hypertension

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Sato, N., Gheorghiade, M., Kajimoto, K., Munakata, R., Minami, Y., Mizuno, M., ... Takano, T. (2013). Hyponatremia and in-hospital mortality in patients admitted for heart failure (from the ATTEND Registry). American Journal of Cardiology, 111(7), 1019-1025. https://doi.org/10.1016/j.amjcard.2012.12.019

Hyponatremia and in-hospital mortality in patients admitted for heart failure (from the ATTEND Registry). / Sato, Naoki; Gheorghiade, Mihai; Kajimoto, Katsuya; Munakata, Ryo; Minami, Yuichiro; Mizuno, Masayuki; Aokage, Toshiyuki; Asai, Kuniya; Sakata, Yasushi; Yumino, Dai; Mizuno, Kyoichi; Takano, Teruo.

In: American Journal of Cardiology, Vol. 111, No. 7, 01.04.2013, p. 1019-1025.

Research output: Contribution to journalArticle

Sato, N, Gheorghiade, M, Kajimoto, K, Munakata, R, Minami, Y, Mizuno, M, Aokage, T, Asai, K, Sakata, Y, Yumino, D, Mizuno, K & Takano, T 2013, 'Hyponatremia and in-hospital mortality in patients admitted for heart failure (from the ATTEND Registry)', American Journal of Cardiology, vol. 111, no. 7, pp. 1019-1025. https://doi.org/10.1016/j.amjcard.2012.12.019
Sato, Naoki ; Gheorghiade, Mihai ; Kajimoto, Katsuya ; Munakata, Ryo ; Minami, Yuichiro ; Mizuno, Masayuki ; Aokage, Toshiyuki ; Asai, Kuniya ; Sakata, Yasushi ; Yumino, Dai ; Mizuno, Kyoichi ; Takano, Teruo. / Hyponatremia and in-hospital mortality in patients admitted for heart failure (from the ATTEND Registry). In: American Journal of Cardiology. 2013 ; Vol. 111, No. 7. pp. 1019-1025.
@article{fd27690b6df742f58f95c01f98bda872,
title = "Hyponatremia and in-hospital mortality in patients admitted for heart failure (from the ATTEND Registry)",
abstract = "Hyponatremia is known to be a poor prognostic factor in patients hospitalized with heart failure (HF), however not well studied in Japan. The aims of this study were to characterize hyponatremic hospitalized patients with HF and to clarify the relations between hyponatremia and detailed in-hospital outcomes in Japan. Among 4,837 hospitalized patients with HF enrolled in the Acute Decompensated Heart Failure Syndromes (ATTEND) registry, patient characteristics and in-hospital mortality in those with hyponatremia were examined. Hyponatremia (sodium <135 mEq/L) was observed in 11.6{\%} of patients. Patients with hyponatremia were of similar age, included fewer men, and had a higher proportion of previous hospitalizations for HF compared to those with normonatremia. On admission, lower heart rates and blood pressures and higher brain natriuretic peptide levels were observed in patients with hyponatremia. During hospitalization, inotrope levels and mechanical device use were significantly higher in patients with hyponatremia. Rates of all-cause and cardiac death were significantly higher in patients with hyponatremia, 15.0{\%} and 11.4{\%}, respectively, compared to 5.3{\%} and 3.6{\%}, respectively, in those with normonatremia. In hyponatremic hospitalized patients with HF, cardiac death accounted for 76.2{\%} of all-cause death. In conclusion, the present study demonstrates that in Japan hyponatremia in patients hospitalized with HF is relatively common and is associated with a very high in-hospital mortality.",
author = "Naoki Sato and Mihai Gheorghiade and Katsuya Kajimoto and Ryo Munakata and Yuichiro Minami and Masayuki Mizuno and Toshiyuki Aokage and Kuniya Asai and Yasushi Sakata and Dai Yumino and Kyoichi Mizuno and Teruo Takano",
year = "2013",
month = "4",
day = "1",
doi = "10.1016/j.amjcard.2012.12.019",
language = "English",
volume = "111",
pages = "1019--1025",
journal = "American Journal of Cardiology",
issn = "0002-9149",
publisher = "Elsevier Inc.",
number = "7",

}

TY - JOUR

T1 - Hyponatremia and in-hospital mortality in patients admitted for heart failure (from the ATTEND Registry)

AU - Sato, Naoki

AU - Gheorghiade, Mihai

AU - Kajimoto, Katsuya

AU - Munakata, Ryo

AU - Minami, Yuichiro

AU - Mizuno, Masayuki

AU - Aokage, Toshiyuki

AU - Asai, Kuniya

AU - Sakata, Yasushi

AU - Yumino, Dai

AU - Mizuno, Kyoichi

AU - Takano, Teruo

PY - 2013/4/1

Y1 - 2013/4/1

N2 - Hyponatremia is known to be a poor prognostic factor in patients hospitalized with heart failure (HF), however not well studied in Japan. The aims of this study were to characterize hyponatremic hospitalized patients with HF and to clarify the relations between hyponatremia and detailed in-hospital outcomes in Japan. Among 4,837 hospitalized patients with HF enrolled in the Acute Decompensated Heart Failure Syndromes (ATTEND) registry, patient characteristics and in-hospital mortality in those with hyponatremia were examined. Hyponatremia (sodium <135 mEq/L) was observed in 11.6% of patients. Patients with hyponatremia were of similar age, included fewer men, and had a higher proportion of previous hospitalizations for HF compared to those with normonatremia. On admission, lower heart rates and blood pressures and higher brain natriuretic peptide levels were observed in patients with hyponatremia. During hospitalization, inotrope levels and mechanical device use were significantly higher in patients with hyponatremia. Rates of all-cause and cardiac death were significantly higher in patients with hyponatremia, 15.0% and 11.4%, respectively, compared to 5.3% and 3.6%, respectively, in those with normonatremia. In hyponatremic hospitalized patients with HF, cardiac death accounted for 76.2% of all-cause death. In conclusion, the present study demonstrates that in Japan hyponatremia in patients hospitalized with HF is relatively common and is associated with a very high in-hospital mortality.

AB - Hyponatremia is known to be a poor prognostic factor in patients hospitalized with heart failure (HF), however not well studied in Japan. The aims of this study were to characterize hyponatremic hospitalized patients with HF and to clarify the relations between hyponatremia and detailed in-hospital outcomes in Japan. Among 4,837 hospitalized patients with HF enrolled in the Acute Decompensated Heart Failure Syndromes (ATTEND) registry, patient characteristics and in-hospital mortality in those with hyponatremia were examined. Hyponatremia (sodium <135 mEq/L) was observed in 11.6% of patients. Patients with hyponatremia were of similar age, included fewer men, and had a higher proportion of previous hospitalizations for HF compared to those with normonatremia. On admission, lower heart rates and blood pressures and higher brain natriuretic peptide levels were observed in patients with hyponatremia. During hospitalization, inotrope levels and mechanical device use were significantly higher in patients with hyponatremia. Rates of all-cause and cardiac death were significantly higher in patients with hyponatremia, 15.0% and 11.4%, respectively, compared to 5.3% and 3.6%, respectively, in those with normonatremia. In hyponatremic hospitalized patients with HF, cardiac death accounted for 76.2% of all-cause death. In conclusion, the present study demonstrates that in Japan hyponatremia in patients hospitalized with HF is relatively common and is associated with a very high in-hospital mortality.

UR - http://www.scopus.com/inward/record.url?scp=84875220288&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84875220288&partnerID=8YFLogxK

U2 - 10.1016/j.amjcard.2012.12.019

DO - 10.1016/j.amjcard.2012.12.019

M3 - Article

C2 - 23312128

AN - SCOPUS:84875220288

VL - 111

SP - 1019

EP - 1025

JO - American Journal of Cardiology

JF - American Journal of Cardiology

SN - 0002-9149

IS - 7

ER -