Hypoadiponectinemia and circulating angiogenic factors in overweight patients complicated with pre-eclampsia

Naoko Suwaki, Hisashi Masuyama, Hideki Nakatsukasa, Akio Masumoto, Yumi Sumida, Norio Takamoto, Yuji Hiramatrsu

Research output: Contribution to journalArticle

63 Citations (Scopus)

Abstract

Objective: Obesity is a risk factor for pre-eclampsia, and adiponectin is an important adipocyte-derived hormone that might protect the endothelium. Recent reports have underlined importance of circulating angiogenic factors for pathophysiology of pre-eclampsia. Here we examined whether adiponectin in conjunction with angiogenic factors plays some roles in the pathophysiology of pre-eclampsia. Study design: We measured serum concentrations of adiponectin and angiogenic factors, vascular endothelial growth factor, placental growth factor, and the soluble vascular endothelial growth factor receptors, soluble fms-like tyrosine Kinase 1 (sFlt-1) and soluble fetal liver kinase 1 (sFlk-1), in women with pre-eclampsia and healthy pregnant women. We also investigated the differences of these factors in overweight and normal-weight patients with pre-eclampsia. Results: Significant correlations were found among the circulating adiponectin and angiogenic factors placental growth factor (R = 0.772, P = .0012) and sFlt-1 (R = 0.787, P = .0005); while, no correlation was found between adiponectin and sFlk-1 (R = 0.3, P = .3434) in patients with pre-eclampsia. Overweight patients with pre-eclampsia showed significantly lower adiponectin levels and a mild imbalance of circulating angiogenic factors, compared with normal-weight patients with pre-eclampsia. Conclusion: Overweight women with pre-eclampsia appeared to have lower levels of adiponectin and sFlt1 and higher levels of placental growth factor than women with pre-eclampsia who were of normal weight. These results suggest that hypoadiponectinemia might be involved in the pathophysiology of overweight patients with pre-eclampsia.

Original languageEnglish
Pages (from-to)1687-1692
Number of pages6
JournalAmerican Journal of Obstetrics and Gynecology
Volume195
Issue number6
DOIs
Publication statusPublished - Dec 2006

Fingerprint

Angiogenesis Inducing Agents
Pre-Eclampsia
Adiponectin
Vascular Endothelial Growth Factor Receptor-1
Vascular Endothelial Growth Factor Receptor-2
Intercellular Signaling Peptides and Proteins
Weights and Measures
Hypoadiponectinemia
Vascular Endothelial Growth Factor Receptor
Adipocytes
Vascular Endothelial Growth Factor A
Endothelium
Pregnant Women
Obesity
Hormones

Keywords

  • Adiponectin
  • Angiogenic factor
  • Obesity
  • Pre-eclampsia

ASJC Scopus subject areas

  • Medicine(all)
  • Obstetrics and Gynaecology

Cite this

Hypoadiponectinemia and circulating angiogenic factors in overweight patients complicated with pre-eclampsia. / Suwaki, Naoko; Masuyama, Hisashi; Nakatsukasa, Hideki; Masumoto, Akio; Sumida, Yumi; Takamoto, Norio; Hiramatrsu, Yuji.

In: American Journal of Obstetrics and Gynecology, Vol. 195, No. 6, 12.2006, p. 1687-1692.

Research output: Contribution to journalArticle

Suwaki, Naoko ; Masuyama, Hisashi ; Nakatsukasa, Hideki ; Masumoto, Akio ; Sumida, Yumi ; Takamoto, Norio ; Hiramatrsu, Yuji. / Hypoadiponectinemia and circulating angiogenic factors in overweight patients complicated with pre-eclampsia. In: American Journal of Obstetrics and Gynecology. 2006 ; Vol. 195, No. 6. pp. 1687-1692.
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