TY - JOUR
T1 - Hypnotic and sleep quality-enhancing properties of kavain in sleep-disturbed rats
AU - Tsutsui, Ryuki
AU - Shinomiya, Kazuaki
AU - Takeda, Yasuhiro
AU - Obara, Yoshihito
AU - Kitamura, Yoshihisa
AU - Kamei, Chiaki
PY - 2009
Y1 - 2009
N2 - The present study was performed to investigate the effects of kavain on the sleepwake cycle in comparison with that of rilmazafone and diphenhydramine using sleep-disturbed rats. Electrodes for the electroencephalogram (EEG) and electromyogram (EMG) were implanted into Wistar rats. Total awake time, non-rapid eye movement (non-REM) sleep and rapid eye movement (REM) sleep were measured for 6 h. Kavain and rilmazafone showed a significant shortening in sleep latency, decreased awake time, and increased non-REM sleep time. On the other hand, significant shortening of the sleep latency was observed following the administration of diphenhydramine, while no effects were observed on the awake and non-REM sleep time. Moreover, kavain showed a significant increase in delta activity during non-REM sleep in sleep-disturbed rats, whereas a significant decrease in delta power during non-REM sleep was observed with rilmazafone. These results clearly indicate that kavain is a compound with not only hypnotic effects, but also sleep quality-enhancement effects.
AB - The present study was performed to investigate the effects of kavain on the sleepwake cycle in comparison with that of rilmazafone and diphenhydramine using sleep-disturbed rats. Electrodes for the electroencephalogram (EEG) and electromyogram (EMG) were implanted into Wistar rats. Total awake time, non-rapid eye movement (non-REM) sleep and rapid eye movement (REM) sleep were measured for 6 h. Kavain and rilmazafone showed a significant shortening in sleep latency, decreased awake time, and increased non-REM sleep time. On the other hand, significant shortening of the sleep latency was observed following the administration of diphenhydramine, while no effects were observed on the awake and non-REM sleep time. Moreover, kavain showed a significant increase in delta activity during non-REM sleep in sleep-disturbed rats, whereas a significant decrease in delta power during non-REM sleep was observed with rilmazafone. These results clearly indicate that kavain is a compound with not only hypnotic effects, but also sleep quality-enhancement effects.
KW - Hypnotic effect
KW - Kava-kava
KW - Kavain
KW - Sleep
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U2 - 10.1254/jphs.09167FP
DO - 10.1254/jphs.09167FP
M3 - Article
C2 - 19881224
AN - SCOPUS:73349137636
VL - 111
SP - 293
EP - 298
JO - Journal of Pharmacological Sciences
JF - Journal of Pharmacological Sciences
SN - 1347-8648
IS - 3
ER -