Hypnotic and sleep quality-enhancing properties of kavain in sleep-disturbed rats

Ryuki Tsutsui, Kazuaki Shinomiya, Yasuhiro Takeda, Yoshihito Obara, Yoshihisa Kitamura, Chiaki Kamei

Research output: Contribution to journalArticlepeer-review

7 Citations (Scopus)


The present study was performed to investigate the effects of kavain on the sleepwake cycle in comparison with that of rilmazafone and diphenhydramine using sleep-disturbed rats. Electrodes for the electroencephalogram (EEG) and electromyogram (EMG) were implanted into Wistar rats. Total awake time, non-rapid eye movement (non-REM) sleep and rapid eye movement (REM) sleep were measured for 6 h. Kavain and rilmazafone showed a significant shortening in sleep latency, decreased awake time, and increased non-REM sleep time. On the other hand, significant shortening of the sleep latency was observed following the administration of diphenhydramine, while no effects were observed on the awake and non-REM sleep time. Moreover, kavain showed a significant increase in delta activity during non-REM sleep in sleep-disturbed rats, whereas a significant decrease in delta power during non-REM sleep was observed with rilmazafone. These results clearly indicate that kavain is a compound with not only hypnotic effects, but also sleep quality-enhancement effects.

Original languageEnglish
Pages (from-to)293-298
Number of pages6
JournalJournal of Pharmacological Sciences
Issue number3
Publication statusPublished - 2009


  • Hypnotic effect
  • Kava-kava
  • Kavain
  • Sleep

ASJC Scopus subject areas

  • Molecular Medicine
  • Pharmacology


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