Hypnotic activities of chamomile and passiflora extracts in sleep-disturbed rats

Kazuaki Shinomiya, Toshio Inoue, Yoshiaki Utsu, Shin Tokunaga, Takayoshi Masuoka, Asae Ohmori, Chiaki Kamei

Research output: Contribution to journalArticle

30 Citations (Scopus)

Abstract

In the present study, we investigated hypnotic activities of chamomile and passiflora extracts using sleep-disturbed model rats. A significant decrease in sleep latency was observed with chamomile extract at a dose of 300 mg/kg, while passiflora extract showed no effects on sleep latency even at a dose of 3000 mg/kg. No significant effects were observed with both herbal extracts on total times of wakefulness, non-rapid eye movement (non-REM) sleep and REM sleep. Flumazenil, a benzodiazepine receptor antagonist, at a dose of 3 mg/kg showed a significant antagonistic effect on the shortening in sleep latency induced by chamomile extract. No significant effects were observed with chamomile and passiflora extracts on delta activity during non-REM sleep. In conclusion, chamomile extract is a herb having benzodiazepine-like hypnotic activity.

Original languageEnglish
Pages (from-to)808-810
Number of pages3
JournalBiological and Pharmaceutical Bulletin
Volume28
Issue number5
DOIs
Publication statusPublished - May 1 2005

Keywords

  • Chamomile
  • Herbal drug
  • Insomnia
  • Passiflora
  • Rat
  • Sleep-disturbed model

ASJC Scopus subject areas

  • Pharmacology
  • Pharmaceutical Science

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    Shinomiya, K., Inoue, T., Utsu, Y., Tokunaga, S., Masuoka, T., Ohmori, A., & Kamei, C. (2005). Hypnotic activities of chamomile and passiflora extracts in sleep-disturbed rats. Biological and Pharmaceutical Bulletin, 28(5), 808-810. https://doi.org/10.1248/bpb.28.808