TY - JOUR
T1 - Hypervariable regions in the putative glycoprotein of hepatitis C virus
AU - Hijikata, Makoto
AU - Kato, Nobuyuki
AU - Ootsuyama, Yuko
AU - Nakagawa, Masanori
AU - Ohkoshi, Shogo
AU - Shimotohno, Kunitada
N1 - Funding Information:
ACKNOWLEDGMENTS: We thank M. Ohara for comments. This work was supported in part by a Grant in-Aid from the Ministry of Health and Welfare for a Comprehensive 10-Year Strategy for Cancer Control and a Grant in-Aid from the Ministry of Science and Culture, Japan. M.H. is a receipient of a Research Resident fellowship from the Foundation for Promotion of Cancer Research, Japan.
PY - 1991/2/28
Y1 - 1991/2/28
N2 - A comparison of the sequences of the putative glycoprotein region in three independent cDNA clones of hepatitis C virus and of sequences of four other clones revealed extensive genetic variation clustered and interspersed with highly conserved amino acid sequences. We obtained evidence for two hypervariable regions in the putative envelope glycoprotein, one region was assumed to be a potential antigenic site, as deduced from the hydrophilicity and analyses of secondary structures. These observations suggest the existence of a large pool of antigenic variants of hepatitis C virus, in Japan.
AB - A comparison of the sequences of the putative glycoprotein region in three independent cDNA clones of hepatitis C virus and of sequences of four other clones revealed extensive genetic variation clustered and interspersed with highly conserved amino acid sequences. We obtained evidence for two hypervariable regions in the putative envelope glycoprotein, one region was assumed to be a potential antigenic site, as deduced from the hydrophilicity and analyses of secondary structures. These observations suggest the existence of a large pool of antigenic variants of hepatitis C virus, in Japan.
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U2 - 10.1016/S0006-291X(05)81223-9
DO - 10.1016/S0006-291X(05)81223-9
M3 - Article
C2 - 1847805
AN - SCOPUS:0026021431
VL - 175
SP - 220
EP - 228
JO - Biochemical and Biophysical Research Communications
JF - Biochemical and Biophysical Research Communications
SN - 0006-291X
IS - 1
ER -
