Hypervariable regions in the putative glycoprotein of hepatitis C virus

Makoto Hijikata; Nobuyuki Kato; Yuko Ootsuyama; Masanori Nakagawa; Shogo Ohkoshi; Kunitada Shimotohno

doi:10.1016/S0006-291X(05)81223-9

Hypervariable regions in the putative glycoprotein of hepatitis C virus

Makoto Hijikata, Nobuyuki Kato, Yuko Ootsuyama, Masanori Nakagawa, Shogo Ohkoshi, Kunitada Shimotohno

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291 Citations (Scopus)

Abstract

A comparison of the sequences of the putative glycoprotein region in three independent cDNA clones of hepatitis C virus and of sequences of four other clones revealed extensive genetic variation clustered and interspersed with highly conserved amino acid sequences. We obtained evidence for two hypervariable regions in the putative envelope glycoprotein, one region was assumed to be a potential antigenic site, as deduced from the hydrophilicity and analyses of secondary structures. These observations suggest the existence of a large pool of antigenic variants of hepatitis C virus, in Japan.

Original language	English
Pages (from-to)	220-228
Number of pages	9
Journal	Biochemical and Biophysical Research Communications
Volume	175
Issue number	1
DOIs	https://doi.org/10.1016/S0006-291X(05)81223-9
Publication status	Published - Feb 28 1991
Externally published	Yes

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ASJC Scopus subject areas

Biochemistry
Biophysics
Molecular Biology

Cite this

Hijikata, M., Kato, N., Ootsuyama, Y., Nakagawa, M., Ohkoshi, S., & Shimotohno, K. (1991). Hypervariable regions in the putative glycoprotein of hepatitis C virus. Biochemical and Biophysical Research Communications, 175(1), 220-228. https://doi.org/10.1016/S0006-291X(05)81223-9

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AU - Shimotohno, Kunitada

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10.1016/S0006-291X(05)81223-9