Abstract
A comparison of the sequences of the putative glycoprotein region in three independent cDNA clones of hepatitis C virus and of sequences of four other clones revealed extensive genetic variation clustered and interspersed with highly conserved amino acid sequences. We obtained evidence for two hypervariable regions in the putative envelope glycoprotein, one region was assumed to be a potential antigenic site, as deduced from the hydrophilicity and analyses of secondary structures. These observations suggest the existence of a large pool of antigenic variants of hepatitis C virus, in Japan.
| Original language | English |
|---|---|
| Pages (from-to) | 220-228 |
| Number of pages | 9 |
| Journal | Biochemical and Biophysical Research Communications |
| Volume | 175 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - Feb 28 1991 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Biochemistry
- Biophysics
- Molecular Biology
Cite this
Hypervariable regions in the putative glycoprotein of hepatitis C virus. / Hijikata, Makoto; Kato, Nobuyuki; Ootsuyama, Yuko; Nakagawa, Masanori; Ohkoshi, Shogo; Shimotohno, Kunitada.
In: Biochemical and Biophysical Research Communications, Vol. 175, No. 1, 28.02.1991, p. 220-228.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Hypervariable regions in the putative glycoprotein of hepatitis C virus
AU - Hijikata, Makoto
AU - Kato, Nobuyuki
AU - Ootsuyama, Yuko
AU - Nakagawa, Masanori
AU - Ohkoshi, Shogo
AU - Shimotohno, Kunitada
PY - 1991/2/28
Y1 - 1991/2/28
N2 - A comparison of the sequences of the putative glycoprotein region in three independent cDNA clones of hepatitis C virus and of sequences of four other clones revealed extensive genetic variation clustered and interspersed with highly conserved amino acid sequences. We obtained evidence for two hypervariable regions in the putative envelope glycoprotein, one region was assumed to be a potential antigenic site, as deduced from the hydrophilicity and analyses of secondary structures. These observations suggest the existence of a large pool of antigenic variants of hepatitis C virus, in Japan.
AB - A comparison of the sequences of the putative glycoprotein region in three independent cDNA clones of hepatitis C virus and of sequences of four other clones revealed extensive genetic variation clustered and interspersed with highly conserved amino acid sequences. We obtained evidence for two hypervariable regions in the putative envelope glycoprotein, one region was assumed to be a potential antigenic site, as deduced from the hydrophilicity and analyses of secondary structures. These observations suggest the existence of a large pool of antigenic variants of hepatitis C virus, in Japan.
UR - http://www.scopus.com/inward/record.url?scp=0026021431&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0026021431&partnerID=8YFLogxK
U2 - 10.1016/S0006-291X(05)81223-9
DO - 10.1016/S0006-291X(05)81223-9
M3 - Article
VL - 175
SP - 220
EP - 228
JO - Biochemical and Biophysical Research Communications
JF - Biochemical and Biophysical Research Communications
SN - 0006-291X
IS - 1
ER -