Hypervariable regions in the putative glycoprotein of hepatitis C virus

Makoto Hijikata, Nobuyuki Kato, Yuko Ootsuyama, Masanori Nakagawa, Shogo Ohkoshi, Kunitada Shimotohno

Research output: Contribution to journalArticle

291 Citations (Scopus)


A comparison of the sequences of the putative glycoprotein region in three independent cDNA clones of hepatitis C virus and of sequences of four other clones revealed extensive genetic variation clustered and interspersed with highly conserved amino acid sequences. We obtained evidence for two hypervariable regions in the putative envelope glycoprotein, one region was assumed to be a potential antigenic site, as deduced from the hydrophilicity and analyses of secondary structures. These observations suggest the existence of a large pool of antigenic variants of hepatitis C virus, in Japan.

Original languageEnglish
Pages (from-to)220-228
Number of pages9
JournalBiochemical and Biophysical Research Communications
Issue number1
Publication statusPublished - Feb 28 1991
Externally publishedYes


ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Molecular Biology

Cite this