Hypersensitivity to mosquito bites with natural-killer cell lymphocytosis: The possible implication of Epstein-Barr virus reactivation

Masataka Satoh, Noritaka Oyama, Hitoshi Akiba, Mikio Ohtsuka, Keiji Iwatsuki, Fumio Kaneko

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

Hypersensitivity to mosquito bites (HMB) has been recognized as one of the wide variety of Epstein-Barr virus (EBV)-associated lymphoproliferative disorders, some of which overlap with chronic active EBV infection and hydroa vacciniforme. It frequently predisposes to hemophagocytic syndrome or lymphoid malignancy with a clonal EBV replication. Here we report an 8-year-old Japanese boy who presented with a 3-year history of HMB. Every summer, he had repeated severe local skin reactions with high-grade fever, lymphadenopathy, and mild liver dysfunction after mosquito bites. Histologically, lymphoid cells overexpressing EBV-encoded small nuclear RNAs (EBER), a marker of latent EBV infection, and eosinophils infiltrated diffusely into the lesional skin. His blood tests showed a marked increase in the CD11b+ 16+ 56+ natural-killer cell population (∼ 50% of the peripheral lymphocytes), but neither a clonal proliferation of EBV nor abnormal antibody titers to EBV. Quantitative PCR using a cloned EBV-determined nuclear antigen (EBNA)-1 vector revealed that a high copy number of the EBV genome is integrated into his peripheral blood cells even during the mosquito-free winter. Based on this evidence, he was diagnosed as being in a smoldering stage of HMB, in which EBV-associated NK cell lymphoproliferation might participate in its pathogenesis.

Original languageEnglish
Pages (from-to)381-384
Number of pages4
JournalEuropean Journal of Dermatology
Volume12
Issue number4
Publication statusPublished - 2002
Externally publishedYes

Fingerprint

Lymphocytosis
Bites and Stings
Culicidae
Human Herpesvirus 4
Natural Killer Cells
Hypersensitivity
Epstein-Barr Virus Infections
Hydroa Vacciniforme
Epstein-Barr Virus Nuclear Antigens
Lymphocytes
Small Nuclear RNA
Hemophagocytic Lymphohistiocytosis
Skin
Lymphoproliferative Disorders
Hematologic Tests
Virus Replication
Eosinophils
Liver Diseases
Blood Cells
Fever

Keywords

  • Chronic active EBV infection
  • In situ hybridization
  • Lymphoproliferative disorder
  • Natural-killer cells
  • Quantitative PCR

ASJC Scopus subject areas

  • Dermatology

Cite this

Hypersensitivity to mosquito bites with natural-killer cell lymphocytosis : The possible implication of Epstein-Barr virus reactivation. / Satoh, Masataka; Oyama, Noritaka; Akiba, Hitoshi; Ohtsuka, Mikio; Iwatsuki, Keiji; Kaneko, Fumio.

In: European Journal of Dermatology, Vol. 12, No. 4, 2002, p. 381-384.

Research output: Contribution to journalArticle

Satoh, Masataka ; Oyama, Noritaka ; Akiba, Hitoshi ; Ohtsuka, Mikio ; Iwatsuki, Keiji ; Kaneko, Fumio. / Hypersensitivity to mosquito bites with natural-killer cell lymphocytosis : The possible implication of Epstein-Barr virus reactivation. In: European Journal of Dermatology. 2002 ; Vol. 12, No. 4. pp. 381-384.
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