HyperCKemia related to the initial and recurrent attacks of neuromyelitis optica

Shoko Deguchi, Kentaro Deguchi, Kota Sato, Taijun Yunoki, Yosio Omote, Nobutoshi Morimoto, Tomoko Kurata, Masami Ikeda, Toshiyuki Takahashi, Masashi Aoki, Koji Abe

Research output: Contribution to journalArticlepeer-review

28 Citations (Scopus)


We herein report the case of a 60-year-old man showing overexpression of creatine kinase (hyperCKemia) related to initial and recurrent attacks of neuromyelitis optica (NMO). He showed reduced vision, ataxia and dysesthesia, but no symptoms originating in the muscles. Magnetic resonance imaging (MRI) revealed lesions in the optic nerve, medulla oblongata, and spinal cord similar to typical NMO patients. However, femoral MRI and whole positron emission tomography (PET) demonstrated no abnormal findings during an episode of hyperCKemia. This case suggests that hyperCKemia is partly involved in the pathogenesis of NMO in both the central nervous system and myofiber surface, which is usually difficult to detect by clinical imaging modalities alone.

Original languageEnglish
Pages (from-to)2617-2620
Number of pages4
JournalInternal Medicine
Issue number18
Publication statusPublished - 2012


  • Aquaporin 4
  • HyperCKemia
  • Neuromyelitis optica

ASJC Scopus subject areas

  • Internal Medicine


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