Abstract
Background: High prevalence of masked hypertension as well as persistent hypertension was observed in the Chronic Kidney Disease Japan Cohort (CKD-JAC) study. We proposed a novel indicator of blood pressure (BP) load, hyperbaric area index (HBI), calculated from ambulatory blood pressure monitoring (ABPM) data. The characteristic of this index and its relationship with kidney function were also evaluated. Methods: The CKD-JAC study, enrolled 2,977 patients, is a prospective observational study started in September 2007. ABPM was conducted in a sub-group from September 2007 to April 2010 and baseline ABPM data of 1,075 subjects (63.4 % male, 60.7 years old) were analyzed. Results: Mean systolic HBI of male and female patients were 242.3 and 176.5 mmHg×h, respectively. HBI sensitively reflected sex (54.7 mmHg×h higher in males than in females), seasonal effects (51.6 mmHg×h higher in winter than in summer), and advancing CKD stage [(16.5 mmHg×h higher) per −10 mL/min/1.73 m2 in eGFR]. The HBI was a significant factor to associate with reduced kidney function, after adjusting with nocturnal BP change (NBPC), sex, and other variables (p value <0.001). Conclusions: Our findings suggested that HBI might be a novel sensitive indicator for the reduction of kidney function, independent of patterns of NBPC.
| Original language | English |
|---|---|
| Pages (from-to) | 114-124 |
| Number of pages | 11 |
| Journal | Clinical and Experimental Nephrology |
| Volume | 19 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - Jan 1 2015 |
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Keywords
- Ambulatory blood pressure monitoring (ABPM)
- Blood pressure load
- Chronic kidney disease
- Hyperbaric area index
- Hypertension
ASJC Scopus subject areas
- Physiology
- Nephrology
- Physiology (medical)
Cite this
Hyperbaric area index calculated from ABPM elucidates the condition of CKD patients : the CKD-JAC study. / Iimuro, Satoshi; Imai, Enyu; Watanabe, Tsuyoshi; Nitta, Kosaku; Akizawa, Tadao; Matsuo, Seiichi; Makino, Hirofumi; Ohashi, Yasuo; Hishida, Akira.
In: Clinical and Experimental Nephrology, Vol. 19, No. 1, 01.01.2015, p. 114-124.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Hyperbaric area index calculated from ABPM elucidates the condition of CKD patients
T2 - the CKD-JAC study
AU - Iimuro, Satoshi
AU - Imai, Enyu
AU - Watanabe, Tsuyoshi
AU - Nitta, Kosaku
AU - Akizawa, Tadao
AU - Matsuo, Seiichi
AU - Makino, Hirofumi
AU - Ohashi, Yasuo
AU - Hishida, Akira
PY - 2015/1/1
Y1 - 2015/1/1
N2 - Background: High prevalence of masked hypertension as well as persistent hypertension was observed in the Chronic Kidney Disease Japan Cohort (CKD-JAC) study. We proposed a novel indicator of blood pressure (BP) load, hyperbaric area index (HBI), calculated from ambulatory blood pressure monitoring (ABPM) data. The characteristic of this index and its relationship with kidney function were also evaluated. Methods: The CKD-JAC study, enrolled 2,977 patients, is a prospective observational study started in September 2007. ABPM was conducted in a sub-group from September 2007 to April 2010 and baseline ABPM data of 1,075 subjects (63.4 % male, 60.7 years old) were analyzed. Results: Mean systolic HBI of male and female patients were 242.3 and 176.5 mmHg×h, respectively. HBI sensitively reflected sex (54.7 mmHg×h higher in males than in females), seasonal effects (51.6 mmHg×h higher in winter than in summer), and advancing CKD stage [(16.5 mmHg×h higher) per −10 mL/min/1.73 m2 in eGFR]. The HBI was a significant factor to associate with reduced kidney function, after adjusting with nocturnal BP change (NBPC), sex, and other variables (p value <0.001). Conclusions: Our findings suggested that HBI might be a novel sensitive indicator for the reduction of kidney function, independent of patterns of NBPC.
AB - Background: High prevalence of masked hypertension as well as persistent hypertension was observed in the Chronic Kidney Disease Japan Cohort (CKD-JAC) study. We proposed a novel indicator of blood pressure (BP) load, hyperbaric area index (HBI), calculated from ambulatory blood pressure monitoring (ABPM) data. The characteristic of this index and its relationship with kidney function were also evaluated. Methods: The CKD-JAC study, enrolled 2,977 patients, is a prospective observational study started in September 2007. ABPM was conducted in a sub-group from September 2007 to April 2010 and baseline ABPM data of 1,075 subjects (63.4 % male, 60.7 years old) were analyzed. Results: Mean systolic HBI of male and female patients were 242.3 and 176.5 mmHg×h, respectively. HBI sensitively reflected sex (54.7 mmHg×h higher in males than in females), seasonal effects (51.6 mmHg×h higher in winter than in summer), and advancing CKD stage [(16.5 mmHg×h higher) per −10 mL/min/1.73 m2 in eGFR]. The HBI was a significant factor to associate with reduced kidney function, after adjusting with nocturnal BP change (NBPC), sex, and other variables (p value <0.001). Conclusions: Our findings suggested that HBI might be a novel sensitive indicator for the reduction of kidney function, independent of patterns of NBPC.
KW - Ambulatory blood pressure monitoring (ABPM)
KW - Blood pressure load
KW - Chronic kidney disease
KW - Hyperbaric area index
KW - Hypertension
UR - http://www.scopus.com/inward/record.url?scp=84896691265&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84896691265&partnerID=8YFLogxK
U2 - 10.1007/s10157-014-0965-2
DO - 10.1007/s10157-014-0965-2
M3 - Article
C2 - 24682891
AN - SCOPUS:84896691265
VL - 19
SP - 114
EP - 124
JO - Clinical and Experimental Nephrology
JF - Clinical and Experimental Nephrology
SN - 1342-1751
IS - 1
ER -