Hydroxyurea as an inhibitor of hepatitis C virus RNA replication

Akito Nozaki, Manabu Morimoto, Masaaki Kondo, Takashi Oshima, Kazushi Numata, Shin Fujisawa, Takeshi Kaneko, Eiji Miyajima, Satoshi Morita, Kyoko Mori, Masanori Ikeda, Nobuyuki Kato, Katsuaki Tanaka

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Hepatitis C virus (HCV) is the main causative agent of chronic liver disease, which may develop into liver cirrhosis and hepatocellular carcinoma. By using a recently developed reporter assay system in which genome-length HCV RNA replicates efficiently, we found that hydroxyurea (HU), a DNA synthesis inhibitor, inhibited HCV RNA replication. Moreover, we demonstrated that the anti-HCV activity of the combination of IFN-alpha and HU was higher than that of IFN-alpha alone. These results suggest that HU may be an effective anti-HCV reagent that can be used not only singly but also in combination with IFN-alpha to treat chronic hepatitis C.

Original languageEnglish
Pages (from-to)601-605
Number of pages5
JournalArchives of Virology
Volume155
Issue number4
DOIs
Publication statusPublished - Apr 2010

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Hydroxyurea
Virus Replication
Hepacivirus
RNA
Nucleic Acid Synthesis Inhibitors
Chronic Hepatitis C
Liver Cirrhosis
Liver Diseases
Hepatocellular Carcinoma
Chronic Disease
Genome

ASJC Scopus subject areas

  • Virology

Cite this

Nozaki, A., Morimoto, M., Kondo, M., Oshima, T., Numata, K., Fujisawa, S., ... Tanaka, K. (2010). Hydroxyurea as an inhibitor of hepatitis C virus RNA replication. Archives of Virology, 155(4), 601-605. https://doi.org/10.1007/s00705-010-0624-1

Hydroxyurea as an inhibitor of hepatitis C virus RNA replication. / Nozaki, Akito; Morimoto, Manabu; Kondo, Masaaki; Oshima, Takashi; Numata, Kazushi; Fujisawa, Shin; Kaneko, Takeshi; Miyajima, Eiji; Morita, Satoshi; Mori, Kyoko; Ikeda, Masanori; Kato, Nobuyuki; Tanaka, Katsuaki.

In: Archives of Virology, Vol. 155, No. 4, 04.2010, p. 601-605.

Research output: Contribution to journalArticle

Nozaki, A, Morimoto, M, Kondo, M, Oshima, T, Numata, K, Fujisawa, S, Kaneko, T, Miyajima, E, Morita, S, Mori, K, Ikeda, M, Kato, N & Tanaka, K 2010, 'Hydroxyurea as an inhibitor of hepatitis C virus RNA replication', Archives of Virology, vol. 155, no. 4, pp. 601-605. https://doi.org/10.1007/s00705-010-0624-1
Nozaki A, Morimoto M, Kondo M, Oshima T, Numata K, Fujisawa S et al. Hydroxyurea as an inhibitor of hepatitis C virus RNA replication. Archives of Virology. 2010 Apr;155(4):601-605. https://doi.org/10.1007/s00705-010-0624-1
Nozaki, Akito ; Morimoto, Manabu ; Kondo, Masaaki ; Oshima, Takashi ; Numata, Kazushi ; Fujisawa, Shin ; Kaneko, Takeshi ; Miyajima, Eiji ; Morita, Satoshi ; Mori, Kyoko ; Ikeda, Masanori ; Kato, Nobuyuki ; Tanaka, Katsuaki. / Hydroxyurea as an inhibitor of hepatitis C virus RNA replication. In: Archives of Virology. 2010 ; Vol. 155, No. 4. pp. 601-605.
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