Hydroxyurea as an inhibitor of hepatitis C virus RNA replication

Akito Nozaki; Manabu Morimoto; Masaaki Kondo; Takashi Oshima; Kazushi Numata; Shin Fujisawa; Takeshi Kaneko; Eiji Miyajima; Satoshi Morita; Kyoko Mori; Masanori Ikeda; Nobuyuki Kato; Katsuaki Tanaka

doi:10.1007/s00705-010-0624-1

Hydroxyurea as an inhibitor of hepatitis C virus RNA replication

Akito Nozaki, Manabu Morimoto, Masaaki Kondo, Takashi Oshima, Kazushi Numata, Shin Fujisawa, Takeshi Kaneko, Eiji Miyajima, Satoshi Morita, Kyoko Mori, Masanori Ikeda, Nobuyuki Kato, Katsuaki Tanaka

Research output: Contribution to journal › Article › peer-review

7 Citations (Scopus)

Abstract

Hepatitis C virus (HCV) is the main causative agent of chronic liver disease, which may develop into liver cirrhosis and hepatocellular carcinoma. By using a recently developed reporter assay system in which genome-length HCV RNA replicates efficiently, we found that hydroxyurea (HU), a DNA synthesis inhibitor, inhibited HCV RNA replication. Moreover, we demonstrated that the anti-HCV activity of the combination of IFN-alpha and HU was higher than that of IFN-alpha alone. These results suggest that HU may be an effective anti-HCV reagent that can be used not only singly but also in combination with IFN-alpha to treat chronic hepatitis C.

Original language	English
Pages (from-to)	601-605
Number of pages	5
Journal	Archives of Virology
Volume	155
Issue number	4
DOIs	https://doi.org/10.1007/s00705-010-0624-1
Publication status	Published - Apr 2010
Externally published	Yes

ASJC Scopus subject areas

Virology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1007/s00705-010-0624-1

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Hydroxyurea as an inhibitor of hepatitis C virus RNA replication. / Nozaki, Akito; Morimoto, Manabu; Kondo, Masaaki; Oshima, Takashi; Numata, Kazushi; Fujisawa, Shin; Kaneko, Takeshi; Miyajima, Eiji; Morita, Satoshi; Mori, Kyoko; Ikeda, Masanori; Kato, Nobuyuki; Tanaka, Katsuaki.

In: Archives of Virology, Vol. 155, No. 4, 04.2010, p. 601-605.

Research output: Contribution to journal › Article › peer-review

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abstract = "Hepatitis C virus (HCV) is the main causative agent of chronic liver disease, which may develop into liver cirrhosis and hepatocellular carcinoma. By using a recently developed reporter assay system in which genome-length HCV RNA replicates efficiently, we found that hydroxyurea (HU), a DNA synthesis inhibitor, inhibited HCV RNA replication. Moreover, we demonstrated that the anti-HCV activity of the combination of IFN-alpha and HU was higher than that of IFN-alpha alone. These results suggest that HU may be an effective anti-HCV reagent that can be used not only singly but also in combination with IFN-alpha to treat chronic hepatitis C.",

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AU - Nozaki, Akito

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AU - Kondo, Masaaki

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AU - Numata, Kazushi

AU - Fujisawa, Shin

AU - Kaneko, Takeshi

AU - Miyajima, Eiji

AU - Morita, Satoshi

AU - Mori, Kyoko

AU - Ikeda, Masanori

AU - Kato, Nobuyuki

AU - Tanaka, Katsuaki

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AB - Hepatitis C virus (HCV) is the main causative agent of chronic liver disease, which may develop into liver cirrhosis and hepatocellular carcinoma. By using a recently developed reporter assay system in which genome-length HCV RNA replicates efficiently, we found that hydroxyurea (HU), a DNA synthesis inhibitor, inhibited HCV RNA replication. Moreover, we demonstrated that the anti-HCV activity of the combination of IFN-alpha and HU was higher than that of IFN-alpha alone. These results suggest that HU may be an effective anti-HCV reagent that can be used not only singly but also in combination with IFN-alpha to treat chronic hepatitis C.

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Hydroxyurea as an inhibitor of hepatitis C virus RNA replication

Abstract

ASJC Scopus subject areas

UN SDGs

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