Hydroxylapatite nanoparticles: Fabrication methods and medical applications

Masahiro Okada, Tsutomu Furuzono

Research output: Contribution to journalReview articlepeer-review

104 Citations (Scopus)


Hydroxylapatite (or hydroxyapatite, HAp) exhibits excellent biocompatibility with various kinds of cells and tissues, making it an ideal candidate for tissue engineering, orthopedic and dental applications. Nanosized materials offer improved performances compared with conventional materials due to their large surface-to-volume ratios. This review summarizes existing knowledge and recent progress in fabrication methods of nanosized (or nanostructured) HAp particles, as well as their recent applications in medical and dental fields. In section 1, we provide a brief overview of HAp and nanoparticles. In section 2, fabrication methods of HAp nanoparticles are described based on the particle formation mechanisms. Recent applications of HAp nanoparticles are summarized in section 3. The future perspectives in this active research area are given in section 4.

Original languageEnglish
Article number064103
JournalScience and Technology of Advanced Materials
Issue number6
Publication statusPublished - Dec 2012
Externally publishedYes


  • coating
  • composite
  • hydroxyapatite
  • medical device
  • nanoparticle

ASJC Scopus subject areas

  • Materials Science(all)


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