Hydroxyapatite/biodegradable poly(l-lactide-co - Caprolactone) composite microparticles as injectable scaffolds by a Pickering emulsion route

Xiangwen Liu, Masahiro Okada, Hayata Maeda, Syuji Fujii, Tsutomu Furuzono

Research output: Contribution to journalArticle

35 Citations (Scopus)

Abstract

Hydroxyapatite (HAp)/biodegradable poly(l-lactide-co - caprolactone) (P(LA/CL)) composite microparticles were fabricated as an injectable scaffold via the Pickering emulsion route in the absence of any molecular surfactants. A stable oil in water emulsion was obtained using water dispersed HAp nanocrystals as the particulate emulsifier and a dichloromethane (CH2Cl 2) solution of P(LA/CL) as the oil phase. The concentration-viscosity relationship of the P(LA/CL) solution and its influence on the formation of a stable emulsion were investigated. The dependence of homogenization on the concentration of the P(LA/CL) solution and shear speed of homogenization was also evaluated. HAp/P(LA/CL) microparticles of various morphologies, such as plates and spheres, or with various surface morphologies were realized through adjustment of the concentration and composition of the P(LA/CL) solution. The microparticles were observed by optical microscopy and scanning electronic microscopy and their size distributions measured using a microparticle size analyzer. The weight percentages of HAp nanocrystals on the HAp/P(LA/CL) microparticles of different average sizes were measured by thermogravimetric analysis.

Original languageEnglish
Pages (from-to)821-828
Number of pages8
JournalActa Biomaterialia
Volume7
Issue number2
DOIs
Publication statusPublished - Feb 1 2011
Externally publishedYes

Keywords

  • Composite
  • Morphology
  • Pickering emulsion
  • Poly(l-lactide-co - caprolactone)
  • Scaffold

ASJC Scopus subject areas

  • Biotechnology
  • Biomaterials
  • Biochemistry
  • Biomedical Engineering
  • Molecular Biology

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