Hydroxyapatite/biodegradable poly(l-lactide-co - Caprolactone) composite microparticles as injectable scaffolds by a Pickering emulsion route

Xiangwen Liu, Masahiro Okada, Hayata Maeda, Syuji Fujii, Tsutomu Furuzono

Research output: Contribution to journalArticle

35 Citations (Scopus)

Abstract

Hydroxyapatite (HAp)/biodegradable poly(l-lactide-co - caprolactone) (P(LA/CL)) composite microparticles were fabricated as an injectable scaffold via the Pickering emulsion route in the absence of any molecular surfactants. A stable oil in water emulsion was obtained using water dispersed HAp nanocrystals as the particulate emulsifier and a dichloromethane (CH2Cl 2) solution of P(LA/CL) as the oil phase. The concentration-viscosity relationship of the P(LA/CL) solution and its influence on the formation of a stable emulsion were investigated. The dependence of homogenization on the concentration of the P(LA/CL) solution and shear speed of homogenization was also evaluated. HAp/P(LA/CL) microparticles of various morphologies, such as plates and spheres, or with various surface morphologies were realized through adjustment of the concentration and composition of the P(LA/CL) solution. The microparticles were observed by optical microscopy and scanning electronic microscopy and their size distributions measured using a microparticle size analyzer. The weight percentages of HAp nanocrystals on the HAp/P(LA/CL) microparticles of different average sizes were measured by thermogravimetric analysis.

Original languageEnglish
Pages (from-to)821-828
Number of pages8
JournalActa Biomaterialia
Volume7
Issue number2
DOIs
Publication statusPublished - Feb 2011
Externally publishedYes

Fingerprint

Durapatite
Emulsions
Hydroxyapatite
Scaffolds
Injections
Composite materials
Nanocrystals
Nanoparticles
Microscopy
Oils
Dichloromethane
Optical microscopy
Surface morphology
Thermogravimetric analysis
Water
Microscopic examination
Methylene Chloride
Surface active agents
caprolactone
dilactide

Keywords

  • Composite
  • Morphology
  • Pickering emulsion
  • Poly(l-lactide-co - caprolactone)
  • Scaffold

ASJC Scopus subject areas

  • Biomaterials
  • Biomedical Engineering
  • Biotechnology
  • Biochemistry
  • Molecular Biology

Cite this

Hydroxyapatite/biodegradable poly(l-lactide-co - Caprolactone) composite microparticles as injectable scaffolds by a Pickering emulsion route. / Liu, Xiangwen; Okada, Masahiro; Maeda, Hayata; Fujii, Syuji; Furuzono, Tsutomu.

In: Acta Biomaterialia, Vol. 7, No. 2, 02.2011, p. 821-828.

Research output: Contribution to journalArticle

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