Hydroxyapatite nanocrystal coating on biodegradable microspheres

Masahiro Okada, Tsutomu Furuzono

Research output: Contribution to journalArticlepeer-review

20 Citations (Scopus)


Nano-sized single crystals of calcined hydroxyapatite (HAp) were uniformly coated on poly(l-lactic acid) (PLLA) microspheres through the ionic interaction between calcium ions on the HAp nanocrystal and carboxyl groups on the PLLA microsphere. In order to coat the substrate with HAp nanocrystals through ionic interaction, the surfaces of the PLLA microspheres were hydrolyzed in an alkaline aqueous solution at pH 11.0 for 1 h at room temperature. The interaction between the HAp nanocrystals and the carboxyl groups originating from PLLA end groups was estimated by Fourier transform infrared spectroscopy. The alkali-treated PLLA microspheres were coated with HAp nanocrystals by immersing the microspheres in an ethanol dispersion of HAp nanocrystals followed by washing in an ultrasonic bath.

Original languageEnglish
Pages (from-to)199-203
Number of pages5
JournalMaterials Science and Engineering B: Solid-State Materials for Advanced Technology
Issue number1-3
Publication statusPublished - 2010
Externally publishedYes


  • Cell adhesion
  • Hydroxyapatite ceramics
  • Nano-sized crystal particle
  • Poly(l-lactic acid)
  • Scaffold
  • Surface morphology

ASJC Scopus subject areas

  • Materials Science(all)
  • Condensed Matter Physics
  • Mechanics of Materials
  • Mechanical Engineering


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