Hydroxyapatite-armored poly(ε-caprolactone) microspheres and hydroxyapatite microcapsules fabricated via a Pickering emulsion route

Syuji Fujii, Masahiro Okada, Taiki Nishimura, Hayata Maeda, Tatsuya Sugimoto, Hiroyuki Hamasaki, Tsutomu Furuzono, Yoshinobu Nakamura

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23 Citations (Scopus)


Hydroxyapatite (HAp) nanoparticle-armored poly(ε-caprolactone) (PCL) microspheres were fabricated via a " Pickering-type" emulsion solvent evaporation method in the absence of any molecular surfactants. It was clarified that the interaction between carbonyl/carboxylic acid groups of PCL and the HAp nanoparticles at an oil-water interface played a crucial role in the preparation of the stable Pickering-type emulsions and the HAp nanoparticle-armored microspheres. The HAp nanoparticle-armored PCL microspheres were characterized in terms of size, size distribution, morphology, and chemical compositions using scanning electron microscopy, laser diffraction, energy dispersive X-ray microanalysis, and thermogravimetric analysis. The presence of HAp nanoparticles at the surface of the microspheres was confirmed by scanning electron microscopy and energy dispersive X-ray microanalysis. Pyrolysis of the PCL cores led to the formation of the corresponding HAp hollow microcapsules.

Original languageEnglish
Pages (from-to)1-8
Number of pages8
JournalJournal of Colloid And Interface Science
Issue number1
Publication statusPublished - May 15 2012



  • Hybrid
  • Hydroxyapatite
  • Microsphere
  • Pickering emulsion
  • Poly(ε-caprolactone)

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Biomaterials
  • Surfaces, Coatings and Films
  • Colloid and Surface Chemistry

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